UID:
almahu_9949983116702882
Umfang:
1 online resource (194 pages)
Ausgabe:
1st ed.
ISBN:
9780443152429
Serie:
Developments in Applied Microbiology and Biotechnology Series
Inhalt:
This comprehensive volume explores the intricacies of pathogenic viruses, focusing on their biology, evolution, and the human immune response. Edited by Awanish Kumar and Kumud Pant, it delves into the history, types, and severity of human pathogenic viruses, as well as the genomic and proteomic aspects. The book examines viral invasion strategies, host immune defenses, and the mechanisms of antiviral drugs. It discusses the role of vaccines in virus prevention, including new methodologies like reverse vaccinology and RNA-based vaccines. The work is aimed at researchers and practitioners in microbiology and biotechnology, offering insights into the challenges of virus detection, vaccine design, and antiviral drug development.
Anmerkung:
Front Cover -- Pathogenic Viruses and Armamentarium Design -- Pathogenic Viruses and Armamentarium DesignDevelopments in Applied Microbiology and BiotechnologyEdited byAwanish KumarDepa ... -- Copyright -- Contents -- Contributors -- 1 - Human pathogenic viruses and tissue virology -- 1. Introduction -- 2. History -- 3. Types of human pathogenic viruses -- 4. Severity and mortality -- 5. Genomics and proteomics -- 6. Phylogeny -- 7. Tissue virology -- 8. Conclusions -- References -- 2 - Past, present, and future of pathogenic viruses -- 1. Introduction -- 2. Viruses in historical records -- 3. Dawn of ancient pathogenic viruses in plants and animals -- 4. Why study viruses? -- 5. New emerging and evolving viruses -- 6. Reason for emergence of new viruses -- 7. Reasons for reemerging viruses -- 8. Adaptation of viruses to human hosts -- 9. Challenges -- 10. Detecting emergence of pandemics -- 11. Prediction of emergence of novel zoonotic pathogens from wild life -- 12. Future prospect for pathogenic virus -- References -- 3 - Viral cell annexation strategies: Cell surface receptor interfaces, infection, and host range -- 1. Introduction -- 2. Invasion, routes of infection, and viral shedding -- 3. Tissue tropism, receptor interactions, and host range -- 4. Proviral determinants and host restriction factors in viral pathogenesis -- 5. Conclusion -- References -- 4 - Host immune response against viruses -- 1. Introduction -- 2. Viral entry in the host cell -- 3. Host immune defense system -- 4. Innate immunity against viruses -- 5. Adaptive immunity against viruses -- 6. Host immune response against SARS-CoV-2 -- 7. Host immune response against human papilloma virus -- 8. Conclusion -- Conflict of interest -- References -- 5 - Antiviral drugs: Types and mechanism of action -- 1. Introduction -- 2. Virus infection cycle -- 2.1 Attachment.
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2.2 Penetration -- 2.3 Release of genetic material with multiplication -- 3. Classification of antiviral drugs based on viral targets -- 3.1 Antiviral drugs inhibit nucleic acid replication -- 3.1.1 Acyclovir -- 3.1.2 Valacyclovir -- 3.1.3 Remdesivir -- 3.1.4 Favipiravir -- 3.1.5 Ribavirin -- 3.2 Antiviral drugs inhibiting viral protein synthesis -- 3.2.1 Lopinavir/ritonavir -- 3.2.2 Atazanavir -- 3.3 Antiviral drugs inhibit interaction between the host-viral genome -- 3.3.1 Raltegravir -- 3.3.2 Elvitegravir -- 3.4 Antiviral drugs inhibit viral entry -- 3.4.1 Docosanol -- 3.4.2 Enfuvirtide -- 3.5 Immunomodulators -- 3.5.1 Nitazoxanide -- 3.6 Other important antiviral drugs -- 4. Future of antiviral drugs -- 5. Conclusion -- References -- 6 - Identifying antiviral targets: Dry lab experimentation -- 1. Virtual screening -- 2. Viral targets and identification -- 3. A table reflecting antiviral targets of hosts and virus -- 4. Antiviral targets and in silico studies -- 5. Step I-hit and lead identification -- 6. Lead optimization -- 7. Drug likeliness -- References -- 7 - Clinic viral diagnostics, viral vaccines, and advanced immunology -- 1. Introduction -- 2. Viral diagnostic techniques -- 3. Various vaccine candidates -- 3.1 Recombinant protein vaccines -- 3.2 DNA vaccines -- 3.3 Viral vector vaccines -- 3.4 RNA-based vaccines -- 4. Mechanism of action of different vaccine candidates -- 5. Conclusion -- Conflict of interest -- References -- 8 - Selecting target stages in the viral life cycle for antiviral vaccine design -- 1. Introduction -- 2. Various phases of the virus life cycle -- 3. Strategies for designing of antiviral vaccines -- 4. Antiviral effects of nanomaterials -- 5. Properties of nanoparticles that influence the production of an immune response -- 5.1 Dendritic cell activation -- 5.2 Nanovaccine candidates.
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6. Current methods for researching the immunological reactions brought on by antiviral vaccinations -- 6.1 Multiparameter flow cytometry -- 7. Case study of targeting various proteins and development stages for development of antiviral drugs -- 7.1 Remdesivir -- 7.2 Nitazoxanide -- 8. Conclusions -- References -- Further reading -- 9 - Reverse vaccinology and applications as prophylactics -- 1. Introduction -- 2. From Pasteur to reverse vaccinology -- 3. The breakthrough of the MenB vaccine -- 4. Reverse vaccinology approach for designing SARS-COV-2 vaccine -- 5. Reverse vaccinology and cellular immunity -- 6. Modification in reverse vaccinology -- 6.1 Pangenomic reverse vaccinology -- 6.2 Role of comparative genomic strategy in reverse vaccinology -- 7. The contribution of epitope prediction in reverse vaccinology -- 8. Advantages of reverse vaccinology over conventional vaccine development approaches -- 9. Bioinformatics tools for reverse vaccinology -- 10. The use of omics as complementary tools -- 11. Recent applications to vaccines against pathogens -- 12. Challenges and future perspectives for reverse vaccinology -- References -- 10 - SARS-CoV2 and SARS-CoV2 vaccinology -- 1. Introduction -- 2. Features of coronavirus -- 3. Pathogenicity -- 4. Various vaccine designing strategies for COVID-19 -- 5. Combination vaccines (mix and match vaccines) -- 6. Infodemic -- 7. Challenges and future prospects -- 8. Conclusion -- References -- 11 - Challenges in development of antiviral drugs and vaccines∗ -- 1. Introduction -- 2. WHO list of current global health threats -- 3. Known viral diseases affecting humans and animals -- 4. Most notorious disease causing microbes -- 5. Viruses are obligate parasite -- 6. Types of drugs given to combat virus -- 7. Virucides: Also known as microbicides -- 8. Immunomodulators -- 9. Anti-virals.
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10. Steps in development of antiviral drugs -- 11. Target identification and screening -- 12. Lead generation and optimization -- 13. Preclinical and clinical trials -- 14. Final registration of the drug -- 15. Conclusion -- References -- Index -- Back Cover.
Weitere Ausg.:
Print version: Kumar, Awanish Pathogenic Viruses and Armamentarium Design San Diego : Elsevier Science & Technology,c2024 ISBN 9780443152412
Sprache:
Englisch
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