UID:
almafu_9959328896502883
Format:
1 online resource (ix, 297 pages) :
,
illustrations
ISBN:
0470021411
,
9780470021415
,
0470021403
,
9780470021408
,
047002142X
,
9780470021422
Series Statement:
Novartis Foundation symposium ; 266
Content:
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.℗¡It features regulatory authority perspectives on preferred preclinical test systems and includes topics on℗¡hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.
Note:
Proceedings of the Symposium on The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, held at Novartis Foundation, London, May 4-6, 2004.
,
Editors: Derek J. Chadwick, Jamie Goode.
,
Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart / Gail A. Robertson, Eugenia M.C. Jones and Jinling Wang -- Structure-function studies of the outer mouth and voltage sensor domain of hERG / Gea-Ny Tseng and H. Robert Guy -- Voltage sensor movement in the hERG K channel / David R. Piper, Michael C. Sanguinetti and Martin Tristani-Firouzi -- hERG channel trafficking / Eckhard Ficker, Adrienne Dennis, Yuri Kuryshev, Barbara A. Wible and Arthur M. Brown -- Dynamic control of hERG/IKr by PKA-mediated interactions with 14-3-3 / Anna Kagan and Thomas V. McDonald -- Does hERG coassemble with a [beta] subunit? Evidence for roles of MinK and MiRP1 / Arun Anantharam and Geoffrey W. Abbott -- hERG block, QT liability and sudden cardiac death / Arthur M. Brown -- Structural determinants for high-affinity block of hERG potassium channels / John Mitcheson, Matthew Perry, Phillip Stansfeld, Michael C. Sanguinetti, Harry Witchel and Jules Hancox -- Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs / Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson and José A. Sanchez-Chapula -- In silico modelling : pharmacophores and hERG channel models / Maurizio Recanatini, Andrea Cavalli and Matteo Masetti -- The long QT syndrome : a clinical counterpart of hERG mutations / Peter J. Schwartz -- Cellular mechanisms of Torsade de Pointes / Steven Poelzing and David S. Rosenbaum -- Expression and role of hERG channels in cancer cells / Annarosa Arcangeli -- TRIad, foundation for proarrhythmia (triangulation, reverse use dependence and instability) / Luc M. Hondeghem -- Drug-induced QT interval prolongation : regulatory guidance and perspectives on hERG channel studies / Rashmi R Shah.
Additional Edition:
Print version: HERG cardial potassium channel. New York : J. Wiley, 2005 ISBN 0470021403
Language:
English
Keywords:
Electronic books.
;
Conference papers and proceedings.
;
Electronic books.
;
Conference papers and proceedings.
;
Electronic books.
;
Conference papers and proceedings.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/047002142X
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/047002142X
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/047002142X
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