UID:
edocfu_9959327342202883
Format:
1 online resource (xvii, 616 pages, 12 unnumbered pages of plates) :
,
illustrations (some color)
ISBN:
9780470372531
,
0470372532
,
9780470372524
,
0470372524
Content:
This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous syst.
Note:
DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION; CONTENTS; CONTRIBUTORS; PREFACE; PART I BASIC CONCEPTS; 1 Basic Mitochondrial Physiology in Cell Viability and Death; 2 Basic Molecular Biology of Mitochondrial Replication; 3 Drug-Associated Mitochondrial Toxicity; 4 Pharmacogenetics of Mitochondrial Drug Toxicity; PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY; 5 Features and Mechanisms of Drug-Induced Liver Injury; 6 Cardiovascular Toxicity of Mitochondrial Origin; 7 Skeletal Muscle and Mitochondrial Toxicity; 8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System.
,
9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics10 Nephrotoxicity; 11 Drug Effects in Patients with Mitochondrial Diseases; PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO; 12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function; 13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function; 14 Mitochond.
Additional Edition:
Print version: Drug-induced mitochondrial dysfunction. Hoboken, N.J. : John Wiley & Sons, ©2008 ISBN 0470111313
Additional Edition:
ISBN 9780470111314
Language:
English
Keywords:
Electronic books.
DOI:
10.1002/9780470372531
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470372531
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