Kooperativer Bibliotheksverbund

UID:

Umfang: 1 online resource (various pagings) : , illustrations (some color).

ISBN: 9780750320092 , 9780750320085

Serie: [IOP release $release]

Inhalt: Written by expert contributors, this much-needed book emphasizes a quantitative and comprehensive perspective to explore the many dimensions of cellular Ca2+ signalling. Leading researchers in the field of calcium signaling present key aspects of this process in cells, starting with Ca2+ entry into the cell, its uptake from the cytosol by organelles, such as the endoplasmic reticulum and mitochondria, and the actions of Ca2+ in turn on a variety of important cellular regulatory processes. This research and reference text should prove useful to a wide readership, from students to researchers at many different levels, particularly in physiology, pharmacology, or biomedical engineering. Part of Biophysical Society-IOP series.

Anmerkung: "Version: 202303"--Title page verso. , 1. Introduction / Les Satin. part I. Molecules mediating calcium influx. 2. Calcium channel selectivity and permeation : function meets 3D structure / Richard W. Tsien -- 3. Structure and function of TRP channels / Gilbert Q. Martinez and Eric N. Senning -- 4. Glutamate-gated calcium currents in the central nervous system : structural determinants, regulatory mechanisms, and biological functions / Gary J. Iacobucci and Gabriela K. Popescu , part II. Calcium signaling on channels and other effectors. 5. Monitoring the dynamics of calcium signaling effectors using genetically encoded fluorescent biosensors / Yanghao Zhong, Sohum Mehta and Jin Zhang -- 6. Calcium-activated potassium channels / Alberto J. Gonzalez-Hernandez, Aravind Kshatri and Teresa Giraldez -- 7. Calcium-activated chloride channels / Alec Kittredge, Aaron P. Owji, Sara Ragi, Stephen H. Tsang, Yu Zhang and Tingting Yang , part III. Physiological roles of calcium. 8. Excitation-contraction coupling in skeletal muscle : fast Ca2+ signaling for muscle activation / Martin F. Schneider and Erick O. Hernández-Ochoa -- 9. Voltage-gated Ca2+ channels and excitation-secretion coupling at the synapse / Brittany Williams, Jessica R. Thomas and Amy Lee -- 10. Calcium signaling in context : case studies in endocrine cells / Patrick A. Fletcher and Arthur S. Sherman , part IV. Calcium channels in organelles. 11. Characterization of endo-lysosomal cation channels using calcium imaging / Christian Wahl-Schott, Marc Freichel, Volodymyr Tsvilovsky and Hristo Varbanov -- 12. The structural era of the mitochondrial calcium uniporter / Enrique Balderas, Salah Sommakia, David Eberhardt, Sandra Lee and Dipayan Chaudhuri , part V. Calcium channels and disease. 13. Voltage-gated calcium channelopathies / John W. Hussey, Kevin G. Herold and Ivy E. Dick -- 14. Role of dysregulated calcium in neuropsychiatric diseases / Herie Sun and Anjali M. Rajadhyaksha. , Also available in print. , Mode of access: World Wide Web. , System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Weitere Ausg.: Print version: ISBN 9780750320078

Weitere Ausg.: ISBN 9780750320108

Sprache: Englisch

DOI: 10.1088/978-0-7503-2009-2

URL: https://iopscience.iop.org/book/edit/978-0-7503-2009-2

UID:

Umfang: 1 online resource (398 pages)

Ausgabe: 1st ed.

ISBN: 9780750320092

Serie: Biophysical Society-IOP Series

Inhalt: This book discusses the cellular and molecular basis for the regulation of calcium changes in cells and, in turn, the impact of changes in cell calcium on physiological function.

Anmerkung: Intro -- Acknowledgement -- Editor biographies -- Leslie S Satin -- Manu Ben-Johny -- Ivy E Dick -- List of contributors -- Chapter 1 Introduction -- Acknowledgements -- References -- Chapter 2 Calcium channel selectivity and permeation: function meets 3D structure -- 2.1 Introduction -- 2.1.1 Conclusion #1. The Ca2+ channel pore has an intrinsically large diameter -- 2.1.2 Conclusion #2. At sub-millimolar external Ca2+, the pore's selectivity filter (EEEE locus) is continually occupied by a single Ca2+ ion -- 2.1.3 Conclusion #3. The selectivity filter is supported by 4 carboxyl side chains, provided by glutamate residues from each of the 4 repeats, protruding into the aqueous pathway (EEEE locus) -- no additional high-affinity Ca2+ binding site are uncovered by looking beyond it or splitting it up -- 2.1.4 Conclusion #4. It is the EEEE locus itself that becomes occupied by multiple divalent ions at higher divalent concentrations -- 2.1.5 Conclusion #5. The rate of Ca2+ arrival at the EEEE locus approaches the diffusion limit -- 2.1.6 Conclusion #6. CaV1 channels exemplify principles found in other Ca2+-selective pores -- 2.1.7 Conclusion #7. CaV channels employ a selectivity mechanism distinct from K+ and Na+ channels, yet illuminating channel evolution -- 2.1.8 Conclusion #8. Studies of Ca2+ channel selectivity and permeation exemplify advantages of studying biological function with multiple approaches -- Acknowledgments -- References -- Chapter 3 Structure and function of TRP channels -- 3.1 What's in a name? -- 3.2 Sequence similarity in TRP channels -- 3.3 The conserved 6-TM core of TRP channels -- 3.4 TRP channel structures -- 3.5 TRP channel ligand binding -- 3.6 Endogenous TRP ligands -- 3.7 Ca2+-dependent modulation -- 3.8 Thermosensitivity in TRP channels -- 3.9 Selectivity filter and pore -- 3.10 Cytsolic domains of TRP channels. , 3.11 Ankyrin repeat domains -- 3.12 Coiled coil domains -- 3.13 Post-translational modifications -- 3.14 Summary -- References -- Chapter 4 Glutamate-gated calcium currents in the central nervous system: structural determinants, regulatory mechanisms, and biological functions -- 4.1 Introduction -- 4.2 Functional aspects of NMDA receptor gating, conductance, and permeation -- 4.2.1 Characteristic features of the macroscopic current -- 4.2.2 Characteristic features of the single-molecule current -- 4.2.3 Functional aspects of NMDA receptor interactions with calcium -- 4.3 Structural aspects of NMDA receptor interactions with calcium -- 4.3.1 Pore determinants of calcium-dependent modulatory mechanisms -- 4.3.2 Extracellular determinants of calcium-dependent modulatory mechanisms -- 4.3.3 Intracellular determinants of calcium-dependent modulatory mechanisms -- 4.4 Biological functions of calcium-dependent regulatory mechanisms -- References -- Chapter 5 Monitoring the dynamics of calcium signaling effectors using genetically encoded fluorescent biosensors -- 5.1 Introduction -- 5.1.1 General design strategies of biosensors for calcium effectors -- 5.1.2 FRET-based biosensors -- 5.1.3 Single-fluorescent protein-based biosensors -- 5.2 Monitoring calcium effector proteins in living cells -- 5.2.1 CaM -- 5.2.2 CaMKII -- 5.2.3 CaN -- 5.2.4 PKC -- 5.3 Urgent needs in the field -- 5.4 Summary and outlook -- Acknowledgements -- References -- Chapter 6 Calcium-activated potassium channels -- 6.1 Introduction -- 6.2 BK channels -- 6.2.1 BK function and physiological roles -- 6.2.2 BK regulation by auxiliary subunits -- 6.2.3 Structural basis of BK channel function -- 6.3 SK and IK channels -- 6.3.1 SK and IK function and physiological roles -- 6.3.2 Structural determinants of SK/IK channel function and regulation by CaM -- 6.3.3 KCa channelopathies. , 6.4 Concluding remarks -- References -- Chapter 7 Calcium-activated chloride channels -- 7.1 Introduction -- 7.1.1 The role of Cl− -- 7.1.2 Ca2+-dependence -- 7.1.3 Ion selectivity and pharmacology -- 7.2 Bestrophins -- 7.2.1 Introduction -- 7.2.2 Structure -- 7.3 Best1 -- 7.3.1 Best1 function -- 7.3.2 Ca2+-dependent inactivation ('rundown') -- 7.3.3 ATP-dependent activity -- 7.3.4 Best1 physiological roles -- 7.3.5 Best1 implications in diseases -- 7.4 Best2 -- 7.4.1 Best2 structure and function -- 7.4.2 Best2 physiological roles -- 7.4.3 Best2 implications in disease -- 7.5 Best3 and Best4 -- 7.5.1 Best3 and Best4 structure and function -- 7.5.2 Best3 physiological roles -- 7.5.3 Best3 implications in disease -- 7.5.4 Best4 -- 7.6 Introduction to the TMEM16/anoctamin family of CaCCs -- 7.6.1 General structure of the TMEM16s -- 7.6.2 The ion conduction pathway -- 7.6.3 The Ca2+ binding site and gating -- 7.7 TMEM16A -- 7.7.1 TMEM16A function and structure -- 7.7.2 TMEM16A physiological roles -- 7.7.3 TMEM16A implications in disease -- 7.8 TMEM16B -- 7.8.1 TMEM16B function and structure -- 7.8.2 TMEM16B physiological roles -- 7.8.3 TMEM16B implications in disease -- 7.9 TMEM16F -- 7.9.1 TMEM16F physiological roles -- 7.9.2 TMEM16F implications in disease -- References -- Chapter 8 Excitation-contraction coupling in skeletal muscle: fast Ca2+ signaling for muscle activation -- 8.1 Introduction to Ca2+ signaling in skeletal muscle -- 8.2 Structural organization of Ca2+ channels in skeletal muscle fibers -- 8.3 Muscle fiber Ca2+ transients -- 8.3.1 Ca2+ indicator dyes used in muscle fibers -- 8.3.2 Introducing Ca2+ indicator dyes into muscle fibers -- 8.3.3 The [Ca2+-dye] signal during fiber depolarization -- 8.3.4 Calculating the free [Ca2+] time course from the measured [Ca2+-dye] signals -- 8.3.5 Ca2+ binding to TnC. , 8.3.6 Time course of Ca2+ binding to thin filament TnC in response to a muscle action potential -- 8.3.7 Calculating the rate of release of Ca2+ from the SR during fiber depolarization -- 8.3.8 Ca2+ release activation and inactivation during fiber depolarization -- 8.4 Sub-sarcomeric Ca2+ gradients within the macroscopic signals? -- 8.5 Unitary Ca2+ release events -- 8.6 local non-sarcomeric Ca2+ signals: CaV1.1 and perinuclear Ca2+ signals -- 8.7 CaV1.1: voltage sensors for ECC -- 8.7.1 CaV1.1 has pseudo 4 fold symmetry of V sensor domains, but full L-type Ca2+ channel is highly asymmetric -- 8.7.2 SR Ca2+ release channels in skeletal muscle -- 8.7.3 The CaV1.1 is the voltage sensor and the dominant regulator of RyR1 -- 8.7.4 Regions of CaV1.1 that are important for activating RyR1 -- 8.7.5 CaV1.1 channel gating modified in CaV1.1s coupled to RyR1 and CaV1.1 uncoupled RYR1 -- 8.7.6 CaV1.1 provides voltage sensor for both intrinsic (in CaV1.1) and extrinsic (in RyR1) Ca2+ channels -- 8.7.7 All four V sensors may not be active in each coupled CaV1.1 -- 8.8 Relaxation and SR Ca2+ uptake -- 8.9 CaV1.1 modulation -- 8.10 RyR1 modulation -- 8.11 RYR1 and disease states -- 8.12 CaV1.1 channelopathies -- 8.13 Conclusion -- Funding -- Author contributions -- Acknowledgments -- References -- Chapter 9 Voltage-gated Ca2+ channels and excitation-secretion coupling at the synapse -- 9.1 Introduction -- 9.2 CaV subtypes modulate release properties at different types of synapses -- 9.2.1 CaV2 subtypes mediate fast neurotransmitter release at most conventional synapses -- 9.2.2 CaV1 channels mediate transmission at sensory ribbon synapses -- 9.3 Ca2+-dependent modulation of CaV channels and neurotransmitter release -- 9.3.1 Alternative splicing modulates CDI of CaV2.1 -- 9.3.2 Molecular determinants for CDF in CaV2.1 and regulation by alternative splicing. , 9.3.3 Ca2+-dependent modulation of CaV2 channels and presynaptic plasticity -- 9.4 Ca2+-dependent modulation of CaV1 channels at ribbon synapses -- 9.4.1 CaBPs as modulators of CaV1 CDI -- 9.4.2 A C-terminal modulator suppresses CDI and modulates activation of CaV1 subtypes -- 9.4.3 Alternative splicing of the CTD modulates CaV1 CDI -- 9.5 Conclusions -- Acknowledgments -- References -- Chapter 10 Calcium signaling in context: case studies in endocrine cells -- 10.1 Introduction -- 10.2 Calcium signal encoding via membrane potential oscillations in an endocrine pituitary cell model -- 10.3 IP3-dependent calcium oscillations -- 10.4 Calcium oscillations in pancreatic beta cells -- 10.5 Conclusion -- References -- Chapter 11 Characterization of endo-lysosomal cation channels using calcium imaging -- 11.1 Introduction -- 11.1.1 Global cytosolic Ca2+ measurements -- 11.1.2 Peri-vesicular Ca2+ imaging -- 11.1.3 Ca2+ imaging of endo-lysosomal Ca2+ channels redirected to the plasma membrane -- 11.1.4 Fura-Dextran or Oregon-Green 488 BAPTA-1 dextran imaging -- 11.1.5 Endo-lysosomal Ca2+ refilling assay to investigate reloading of endo-lysosomal Ca2+ stores -- 11.1.6 Endo-lysosomal Ca2+ refilling assay using Fura-Dextran or Oregon-Green 488 or BAPTA-1 dextran imaging -- 11.2 Conclusions -- References -- Chapter 12 The structural era of the mitochondrial calcium uniporter -- 12.1 Introduction -- 12.1.1 The mitochondrial Ca2+ uniporter is the main portal for Ca2+ influx into the matrix -- 12.1.2 The uniporter is a highly-selective Ca2+ channel -- 12.1.3 The uniporter channel is composed of multiple subunits -- 12.2 MCU -- 12.2.1 The MCU gene encodes the channel pore -- 12.2.2 Most evidence suggests the channel is a tetramer of MCU subunits -- 12.2.3 Ca2+ selectivity relies on concentric rings of negatively-charged residues and an extremely rigid bottleneck. , 12.2.4 A wide vestibule beyond the selectivity filter allows rapid Ca2+ conduction.

Weitere Ausg.: Print version: Satin, Leslie S. Calcium Signals Bristol : Institute of Physics Publishing,c2023 ISBN 9780750320108

Sprache: Englisch

Schlagwort(e): Electronic books.

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