UID:
almafu_9960117818102883
Format:
1 online resource (xxvii, 476 pages) :
,
digital, PDF file(s).
ISBN:
1-108-14657-0
,
1-108-14573-6
,
1-107-28187-3
Content:
Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.
Note:
Title from publisher's bibliographic system (viewed on 03 May 2017).
,
Cover -- Half-title page -- Title page -- Copyright page -- Dedication -- Contents -- List of Contributors -- Foreword -- Preface -- Part I Optogenetics in Model Organisms -- 1 Introduction to Optogenetics: From Neuronal Function to Mapping and Disease Biology -- 2 Uncovering Key Neurons for Manipulation in Mammals -- 3 From Connectome to Function: Using Optogenetics to Shed Light on the Caenorhabditis elegans Nervous System -- 4 From Synapse to Behavior: Optogenetic Tools for the Investigation of the Caenorhabditis elegans Nervous System -- 5 Using Optogenetics In Vivo to Stimulate Regeneration in Xenopus laevis -- Part II Opsin Biology, Tools, and Technology Platform -- 6 Sodium and Engineered Potassium Light-Driven Pumps -- 7 Methods for Simultaneous Electrophysiology and Optogenetics In Vivo -- 8 Application of an Optogenetic Technique to a Study of Activity-dependent Axon Growth in the Developing Cortex -- 9 Development of an Optogenetic Tool to Regulate Protein Stability In Vivo -- 10 Photoactivatable Nucleotide Cyclases for Synthetic Photobiology Applications -- 11 Bioluminescence Activation of Light-sensing Molecules -- Part III Optogenetics in Neurobiology, Brain Circuits, and Plasticity -- 12 Optogenetics for Neurological Disorders: What Is the Path to the Clinic? -- 13 Optogenetic Control of Astroglia -- 14 Optogenetics for Neurohormones and Neuropeptides: Focus on Oxytocin -- 15 Optogenetic Approaches to Investigating Brain Circuits -- 16 Optogenetic Mapping of Neuronal Connections and their Plasticity -- Part IV Optogenetics in Learning, Neuropsychiatric Diseases, and Behavior -- 17 Optogenetics to Study Reward Learning and Addiction -- 18 Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disorders.
,
19 Optogenetics Research in Behavioral Neuroscience: Insights into the Brain Basis of Reward Learning and Goal-directed Behavior -- 20 Toward an Optogenetic Therapy for Epilepsy -- 21 Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Function -- Plates -- Part V Optogenetics in Vision Restoration and Memory -- 22 Optogenetics in Treating Retinal Disease -- 23 Optogenetics for Vision Recovery: From Traditional to Designer Optogenetic Tools -- 24 A Promise of Vision Restoration -- 25 Holographic Optical Neural Interfacing with Retinal Neurons -- 26 Strategies for Restoring Vision by Transducing a Channelrhodopsin Gene into Retinal Ganglion Cells -- 27 Optogenetic Dissection of a Top-down Prefrontal to Hippocampus Memory Circuit -- Part VI Optogenetics in Sleep, Prosthetics, and Epigenetics of Neurodegenerative Diseases -- 28 Optogenetic Dissection of Sleep-Wake Control: Evidence for a Thalamic Control of Sleep Architecture -- 29 Optogenetics and Auditory Implants -- 30 Optogenetic Stimulation for Cochlear Prosthetics -- 31 The Role of Amino Acids in Neurodegenerative and Addictive Diseases -- 32 Optogenetics in Deep Brain Stimulation: Ethical Considerations -- Index.
Additional Edition:
ISBN 1-107-05301-3
Additional Edition:
ISBN 1-107-63336-2
Language:
English
Subjects:
Biology
Keywords:
Aufsatzsammlung
URL:
Volltext
(URL des Erstveröffentlichers)
URL:
https://doi.org/10.1017/9781107281875
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