Kooperativer Bibliotheksverbund

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Format: 1 online resource

ISBN: 9781118140291 , 111814029X , 9781119497813 , 1119497817

Content: Annotation

Note: Machine generated contents note: PRINCIPLES AND METHODS -- , Modeling In The Pharmaceutical Industry -- , Introduction -- , Modeling Approaches -- , Steps Needed to Maximize Effective Integration of Models into R&D Workflow -- , Scope of the Book -- , Keywords -- , References -- , Physiologically-Based Modeling -- , Introduction -- , Examples of Physiological Modeling -- , Need for Physiological Models in the Pharmaceutical Industry -- , Organs as Compartments -- , Bottom-Up vs. , Top-Down Modeling in Pharmacokinetics -- , References -- , Review Of Pharmacokinetic Principles -- , Introduction -- , Routes of Administration -- , Drug Disposition -- , Absorption -- , Plasma Protein Binding, Blood-Plasma Ratio -- , Distribution, Elimination, Half-Life, and Clearance -- , Role of Transporters in ADME -- , Linear and Nonlinear Pharmacokinetics -- , Steady-State Pharmacokinetics -- , Dose Estimations -- , Successful PK Optimization in Drug Discovery -- , Keywords -- , References -- , Physiological Model For Absorption -- , Introduction -- , Drug Absorption and Gut Bioavailability -- , Solubility and Dissolution Rate -- , Permeability: Transcelluar, Paracellular, and Carrier-Mediated Pathways -- , Barriers to Membrane Transport -- Luminal Degradation, Efflux, and Gut Metabolism -- , Factors Affecting Drug Absorption and Gut Bioavailability -- , Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology -- , Compound-Dependent Factors -- , Formulation-Dependent Factors -- , In Silico Predictions of Passive Permeability and Solubility -- , In Silico Models for Permeability -- , In Silico Models for Solubility -- , Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism -- , In Vitro, in Situ and in Vivo Assays for Permeability -- , Measurement of Thermodynamic or Equilibrium Solubility -- , Luminal Stability -- , Efflux -- , In Vitro Models for Estimating Extent of Gut Metabolism -- , Absorption Modeling -- , Keywords -- , References -- , Physiological Model For Distribution -- , Introduction -- , Factors Affecting Tissue Distribution of Xenobiotics -- , Physiological Factors and Species Differences in Physiology -- , Compound-Dependent Factors -- , In Silico Models of Tissue Partition Coefficients -- , Measurement of Parameters Representing Rate and Extent of Tissue Distribution -- , Assessment of Rate and Extent of Brain Penetration -- , Physiological Model for Drug Distribution -- , Drug Concentrations at Site of Action -- , Keywords -- , References -- , Physiological Models For Drug Metabolism And Excretion -- , Introduction -- , Factors Affecting Drug Metabolism and Excretion of Xenobiotics -- , Models for Hepatobiliary Elimination and Renal Excretion -- , In Silico Models -- , In Vitro Models for Hepatic Metabolism -- , In Vitro Models for Transporters -- , Physiological Models -- , Hepatobiliary Elimination of Parent Drug and Metabolites -- , Renal Excretion -- , References -- , Generic Whole-Body Physiologically-Based Pharmacokinetic Modeling -- , Introduction -- , Structure of a Generic Whole Body PBPK Model -- , Model Assumptions -- , Commercial PBPK Software -- , References -- , Variability, Uncertainty, And Sensitivity Analysis -- , Introduction -- , Need for Uncertainty Analysis -- , Sources of Physiological, Anatomical, Enzymatic, and Transporter Variability -- , Modeling Uncertainty and Population Variability with Monte Carlo Simulations -- , Sensitivity Analysis -- , Conclusions -- , Keywords -- , References -- , Evaluation Of Drug-Drug Interaction Risk With Pbpk Models -- , Introduction -- , Factors Affecting Drug -- Drug Interactions -- , In Vitro Methods to Evaluate Drug -- Drug Interactions -- , Candidate Drug as a Potential Inhibitor -- , Candidate Drug as a Potential Victim of Inhibition -- , Static Models to Evaluate Drug -- Drug Interactions -- , PBPK Models to Evaluate Drug -- Drug Interactions -- , Intrinsic Clearance of Victim (V) in the Absence of Inhibitor or Inducer -- , Intrinsic Clearance of Victim (V) in the Presence of Inhibitor -- , Time-Dependent Changes in the Abundance of an Enzyme Isoform Inhibited by an MBI -- , Intrinsic Clearance of Victim (V) in the Presence of Inducer -- , Comparison of PBPK Models and Static Models for the Evaluation of Drug -- Drug Interactions -- , Keywords -- , References -- , Physiologically-Based Pharmacokinetics Of Biotherapeutics -- , Introduction -- , Therapeutic Proteins -- , Peptides and Proteins -- , Monoclonal Antibodies -- , Pharmacokinetics of Therapeutic Proteins -- , Peptides and Proteins -- , Monoclonal Antibodies -- , PBPK/PD Modeling for Therapeutic Proteins -- , Need for PBPK Modeling for Therapeutic Proteins -- , PBPK Modeling for Therapeutic Proteins -- , Pharmacokinetic Scaling -- , Applications of PBPK Models of Therapeutic Proteins -- , PBPK Integration with Pharmacodynamics -- , Antisense Oligonucletides and RNA Interferance -- , Antisense Oligonucletides (ASOs) -- , Ribonucleic Acid Interference (RNAi) -- , Pharmacokinetics of ASOs50 and Double-Stranded RNAs -- , Design and Modifications of ASOs to Improve Target Affinity and PD: the First, Second, and Third Generation ASOs -- , Integration of PK/PBPK and PD Modeling -- , Keywords -- , References -- , APPLICATIONS IN THE PHARMACEUTICAL INDUSTRY -- , Data Integration And Sensitivity Analysis -- , Introduction -- , Examples of Data Integration with PBPK Modeling -- , Examples of Sensitivity Analysis with PBPK Modeling -- , References -- , Hypothesis Generation And Pharmacokinetic Predictions -- , Introduction -- , PBPK Simulations of Pharmacokinetic Profiles for Hypothesis Generation and Testing -- , Methodology -- , In Vivo Solubility -- , Delayed Gastric Emptying -- , Regional Variation in Intestinal Loss: Gut Wall Metabolism, Intestinal Efflux, and Luminal Degradation -- , Enterohepatic Recirculation -- , Inhibition of Drug-Metabolizing Enzymes -- , Inhibition of Hepatic Uptake -- , Inhibition of Hepatobiliary Efflux -- , Pharmacokinetic Predictions -- , Human Predictions from Preclinical Data -- , Pharmacokinetic Predictions in Clinical Development -- , References -- , Integration Of Pbpk And Pharmacodynamics -- , Introduction -- , Pharmacodynamic Principles -- , Pharmacological Targets and Drug Action -- , Functional Adaptation Processes: Tolerance, Sensitization, and Rebound (Fig 13.2) -- , Pharmacodynamic Modeling -- , Concentration -- Effect, Dose -- Response Curves, and Sigmoid Emax Models -- , Mechanism-Based PD Modeling -- , Simple Direct Effects -- , Models Accommodating Delayed Pharmacological Response -- , Models Accommodating Nonlinearity in Pharmacological Response with Respect to Time -- , Pharmacokinetic Modeling: Compartmental PK and PBPK -- , Integration of PK or PBPK with PD Modeling -- , Reasons for Poor PK/PD Correlation -- , Applications of PK or PBPK/PD Modeling in Drug Discovery and Development -- , Need for a Mechanistic PBPK/PD Integration -- , Applications of PK or PBPK/PD in Drug Discovery -- , Applications of PK or PBPK/PD in Drug Development -- , Regulatory Perspective -- , Conclusions -- , Keywords -- , References -- , Physiologically-Based Pharmacokinetic Modeling Of Populations -- , Introduction -- , Population Modeling with PBPK -- , Healthy to Target Patient Population: Impact of Disease on Pharmacokinetics -- , Modeling Subpopulations: Impact of Age, Gender, Co-morbidities, and Genetics on Pharmacokinetics -- , Personalized Medicine with PBPK/PD -- , Keyword -- , References -- , PBPK Models Along The Drug Discovery And Development Value Chain , Summary of Applications of PBPK Models along Value Chain -- , Obstacles and Future Directions for PBPK Modeling -- , Keyword -- , References.

Additional Edition: Print version: Peters, Sheila Annie. Physiologically-based pharmacokinetic (PBPK) modeling and simulations Hoboken, N.J. : Wiley, c2012 ISBN 9780470484067

Language: English

Keywords: Electronic books. ; Electronic books.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119497813

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119497813

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119497813

UID:

Format: 1 Online-Ressource.

Edition: Second edition

ISBN: 978-1-118-14029-1 , 1-118-14029-X , 978-1-119-49781-3 , 1-119-49781-7

Content: Machine generated contents note:SECTION IPRINCIPLES AND METHODS --1.Modeling In The Pharmaceutical Industry --1.1.Introduction --1.2.Modeling Approaches --1.3.Steps Needed to Maximize Effective Integration of Models into R&D Workflow --1.4.Scope of the Book --Keywords --References --2.Physiologically-Based Modeling --2.1.Introduction --2.2.Examples of Physiological Modeling --2.3.Need for Physiological Models in the Pharmaceutical Industry --2.4.Organs as Compartments --2.5.Bottom-Up vs.

Content: Top-Down Modeling in Pharmacokinetics --References --3.Review Of Pharmacokinetic Principles --3.1.Introduction --3.2.Routes of Administration --3.3.Drug Disposition --3.3.1.Absorption --3.3.2.Plasma Protein Binding, Blood-Plasma Ratio --3.3.3.Distribution, Elimination, Half-Life, and Clearance --3.3.4.Role of Transporters in ADME --3.4.Linear and Nonlinear Pharmacokinetics --3.5.Steady-State Pharmacokinetics --3.6.Dose Estimations --3.7.Successful PK Optimization in Drug Discovery --Keywords --References --4.Physiological Model For Absorption --4.1.Introduction --4.2.Drug Absorption and Gut Bioavailability --4.2.1.Solubility and Dissolution Rate --4.2.2.Permeability: Transcelluar, Paracellular, and Carrier-Mediated Pathways --4.2.3.Barriers to Membrane Transport --

Content: Luminal Degradation, Efflux, and Gut Metabolism --4.3.Factors Affecting Drug Absorption and Gut Bioavailability --4.3.1.Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology --4.3.2.Compound-Dependent Factors --4.3.3.Formulation-Dependent Factors --4.4.In Silico Predictions of Passive Permeability and Solubility --4.4.1.In Silico Models for Permeability --4.4.2.In Silico Models for Solubility --4.5.Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism --4.5.1.In Vitro,

Note: Includes bibliographical references and index

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781119497684

Language: English

Subjects: Chemistry/Pharmacy

Keywords: Pharmakokinetik ; Mathematische Modellierung ; Electronic books ; Electronic books

DOI: 10.1002/9781119497813

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 online resource (1 volume)

ISBN: 0470484063 , 9780470484067 , 9781280588631 , 1280588632 , 9781118140291 , 111814029X , 9781118140383 , 1118140389

Content: The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void.

Note: Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.

Additional Edition: Print version: ISBN 9786613618467

Language: English

Keywords: Electronic books. ; Electronic books.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118140291

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118140291