UID:
almafu_9959328257602883
Umfang:
1 online resource
ISBN:
9781118697894
,
1118697898
,
9781118697917
,
111869791X
,
9781118697191
,
1118697197
,
1118488520
,
9781118488522
Inhalt:
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated.
Anmerkung:
Introduction to ligand design in medicinal inorganic chemistry -- Platinum-based anticancer agents -- Coordination chemistry and ligand design in the development of metal based radiopharmaceuticals -- Ligand design in D-block optical imaging agents and sensors -- Luminescent lanthanoid probes -- Metal complexes of carbohydrate-targeted ligands in medicinal inorganic chemistry -- Design of Schiff base-derived ligands: applications in therapeutics and medical diagnosis -- Metal-based antimalarial agents -- Therapeutic gold compounds -- Ligand design to target and modulate metal-protein interactions in neurodegenerative diseases -- Rational design of copper and iron chelators to treat Wilson's disease and hemochromatosis -- MRI contrast agents -- Photoactivatable metal complexes and their use in biology and medicine -- Metalloprotein inhibitors -- Ruthenium anticancer compounds with biologically-derived ligands.
,
English.
Weitere Ausg.:
Print version: Ligand design in medicinal inorganic chemistry. Chichester, West Sussex : John Wiley & Sons Inc., 2014 ISBN 9781118488522
Sprache:
Englisch
Schlagwort(e):
Llibres electrònics.
;
Electronic books.
;
Llibres electrònics.
;
Electronic books.
;
Llibres electrònics.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118697191
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118697191
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118697191
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