Umfang:
Online-Ressource (XIII, 74p. 24 illus. in color, digital)
ISBN:
9783642169311
,
1283080990
,
9781283080996
Serie:
Springer Theses
Inhalt:
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
Anmerkung:
Includes bibliographical references
Weitere Ausg.:
ISBN 9783642169304
Weitere Ausg.:
Buchausg. u.d.T. Davidovich, Chen Targeting functional centers of the ribosome Berlin : Springer, 2011 ISBN 9783642169304
Weitere Ausg.:
ISBN 3642169309
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Ribosom
;
Peptidyltransferase
;
Proteinbiosynthese
;
Elongation
;
Ribosom
;
Antibiotikum
;
Ribosom
;
Peptidyltransferase
;
Proteinbiosynthese
;
Elongation
;
Antibiotikum
DOI:
10.1007/978-3-642-16931-1
URL:
Volltext
(lizenzpflichtig)
Mehr zum Autor:
Davidovich, Chen
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