Umfang:
Online-Ressource (XXV, 466p. 67 illus., 53 illus. in color, digital)
ISBN:
9781461405146
,
1283353105
,
9781283353106
Serie:
Protein Reviews 15
Inhalt:
Mark O. J. Olson
Inhalt:
Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. "The Nucleolus" is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus
Anmerkung:
Includes bibliographical references and index
,
The Nucleolus; Preface; The Nucleolus: A Nuclear Body Full of Surprises; The Complex Nucleolus; Nucleolar Structure and Organization; The Role of the Nucleolus in Ribosome Biogenesis; Novel Functions of the Nucleolus; The Future of the Nucleolus; References; Acknowledgments; Contents; Contributors; Part I: Nucleolar Structure and Organization; Chapter 1: Structural Organization of the Nucleolus as a Consequence of the Dynamics of Ribosome Biogenesis; 1.1 Introduction; 1.2 Nucleoli and Ribosome Biogenesis; 1.2.1 Active Ribosome Biogenesis Generates Nucleolar Organization
,
1.2.2 The Building Blocks of the Nucleolar Compartmentation1.2.3 Information Coming from Disrupted Ribosome Production; 1.3 Nucleolar Assembly/Disassembly; 1.4 The Nucleolus in the Nucleus; 1.4.1 Dynamics of the Nucleolar Structures; 1.4.2 Nucleolus and Chromatin; 1.4.3 Relationship Between the Nucleolus and the Nuclear Envelope; 1.5 Conclusions; References; Chapter 2: The Dynamic Proteome of the Nucleolus; 2.1 Introduction; 2.2 Isolation of Nucleoli; 2.3 Proteomic Analysis of Nucleolar Proteins; 2.4 Presentation and Publication of Data; 2.5 Perspectives; References
,
Chapter 3: The Structure of rDNA Chromatin3.1 Introduction; 3.2 Genomic Organization of rDNA; 3.3 Structural Organization of rDNA Chromatin; 3.4 rDNA Chromatin Composition: Proteins and Modifications; 3.5 Conclusions; References; Chapter 4: The Epigenetics of the Nucleolus: Structure and Function of Active and Silent Ribosomal RNA Genes; 4.1 Introduction; 4.2 Chromatin and Epigenetic Features of Active and Silent Genes; 4.3 Inheritance of rDNA Chromatin Structures; 4.4 Regulation of rRNA Synthesis by Epigenetic and Chromatin Related-Mechanisms; 4.5 Function of Silent rRNA Genes
,
4.6 rDNA Silencing and Cancer4.7 Conclusions; References; Chapter 5: UBF an Essential Player in Maintenance of Active NORs and Nucleolar Formation; 5.1 Introduction; 5.2 Chromosomal Organization of rDNA; 5.3 Active vs. Inactive NORs; 5.4 UBF, Domain Structure, and DNA Binding; 5.5 Extensive UBF Binding Defines Active NORs; 5.6 UBF Loading onto the rDNA Repeat; 5.7 UBF Loaded Chromatin, a Platform for Coordinating Ribosome Biogenesis; 5.8 UBF and Nucleolar Reformation; 5.9 UBF and Regulation of Ribosome Biogenesis; 5.10 UBF is Present Across Animal Phyla; References
,
Part II: Role of the Nucleolus in Ribosome BiogenesisChapter 6: The RNA Polymerase I Transcription Machinery; 6.1 Introduction; 6.2 Components of the Pol I Transcription Machinery; 6.2.1 Structure and Function of RNA Polymerase I; 6.2.2 Basal Factors Required for Transcription Initiation; 6.3 The RNA Polymerase I-Dependent Transcription Cycle; 6.3.1 Dynamics of Transcription Complex Assembly; 6.3.2 Elongation of Pol I Transcription; 6.3.3 Termination of Pol I Transcription; 6.3.4 The Upstream Terminator T 0 is an Essential Promoter Element
,
6.4 Nuclear Actin and Myosin Promote Pol I Transcription
Weitere Ausg.:
ISBN 9781461405139
Weitere Ausg.:
Buchausg. u.d.T. The nucleolus New York : Springer, 2011 ISBN 9781461405139
Weitere Ausg.:
ISBN 1461405130
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Nucleolus
;
Nucleolus-Organisator-Region
DOI:
10.1007/978-1-4614-0514-6
URL:
Volltext
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