Umfang:
Online-Ressource (XI, 205 p. 23 illus., 16 illus. in color, online resource)
Ausgabe:
1
ISBN:
9781461406136
,
1283353229
,
9781283353229
Serie:
Cancer Drug Discovery and Development
Inhalt:
Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.¡ This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce large amounts of many kinds of cytokines and by providing the T cell arm of the adaptive immune system a mechanism to detect lipid antigens. NKT cells also have both regulatory and effector functions and have been shown to play critical roles in the regulation of immune responses in many disease settings including cancer. Stimulating the protective functions of NKT cells while inhibiting the negative regulatory activity shows promise for the therapy of cancer and several approaches are in clinical trials. ¡ ¡¡¡¡¡¡¡¡¡¡¡ This book reviews what we have learned about NKT cells during last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell targeted therapy.¡ This knowledge should also be informative to understand the role of this underappreciated T cell population in many other fields outside of tumor immunology
Inhalt:
This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells
Anmerkung:
Includes bibliographical references and index
,
Chapter 1: Introduction: Mechanisms of NKT-Cell-Mediated Adjuvant Activity and Function of iPS-Derived NKT Cells; 1 Introduction; 2 Discovery of NKT Cells; 3 Ligand for NKT Cells; 4 Mechanisms of NKT Cell-Mediated Adjuvant Activity Augmenting Anti-Tumor Responses; 4.1 NKT Cell-Targeted Adjuvant Cell Therapy for Patients with Advanced Lung Cancer; 5 Generation of Induced Pluripotent Stem Cells from Mature NKT Cells; 5.1 Generation of Functional NKT Cells from iPS Cells; 5.2 In Vivo Function of iPS-Derived NKT Cells; 5.3 Adjuvant Activity of iPS-Derived NKT Cells; References
,
Chapter 2: Structure and Recognition of Antigens for Invariant NKT Cells1 Introduction; 2 Synthetic Lipid Ags; 3 Natural Microbial Lipid Ags; 4 Endogenous Lipid Ags; 5 Structural Basis of Lipid Ag Recognition; 6 Conclusion/Summary; References; Chapter 3: Invariant NKT Cell-Based Vaccine Strategies; 1 Introduction; 2 Activation of iNKT Cells; 3 iNKT Cells at the Interface Between Innate and Adaptive Immunity; 4 iNKT Cell-Based Vaccination Strategies; 5 Harnessing iNKT Cells in the Clinic; 6 The Future of iNKT Cell-Based Vaccination Strategies; References
,
Chapter 4: Immune Regulation of Tumor Immunity by NKT Cells1 Definition of NKT Cells; 2 Immune Regulation by Type I NKT Cells; 3 Immune Suppression by Type II NKT Cells; 4 Counterregulation of Type I and Type II NKT Cells; 5 Interactions Between NKT Cells and Other Cell Types; 6 Conclusions; References; Chapter 5: The Regulation of CD1d + and CD1d - Tumors by NKT Cells; 1 Introduction; 2 Different Subsets of NKT Cells; 2.1 Type I NKT Cells; 2.2 Type II NKT Cells; 2.3 CD4 + , CD8 + , or DN NKT Cells; 2.4 IL-17-Producing NKT Cells
,
3 The Regulation of Tumor Immunity by Type I NKT and Type II NKT Cells4 Antitumor Activity of NKT Cells; 4.1 CD1d-Postive Tumor Cells; 4.1.1 Direct Cytolytic Activity Against CD1d + Tumor Cells; 4.1.2 Cytokine Secretion Can Activate NK Cells and CTL-Mediated Cytolysis; 4.1.3 Activation of APCs to Initiate Adaptive Antitumor Immunity; 4.2 CD1d-Negative Tumors and NKT Cells; 5 Evasion from NKT Cell-Mediated Antitumor Innate Immunity; 5.1 Down-Regulation of CD1d Expression; 5.2 Shedding Lipids (or Other Substances) That Can Block CD1d-Mediated Activation of NKT Cells
,
5.3 Abnormal Signal Transduction Pathways in Tumor Cells (or Tumor-Associated APCs) Result in Reduced NKT Activation5.4 Disruption of TCR-Signaling in NKT Cells?; 6 Conclusions and Future Directions; References; Chapter 6: DC-Based Immunotherapy Targeting NKT Cells; 1 Introduction; 2 iNKT Cell Targeting Therapy Using Ex Vivo a -GalCer-Loaded DC; 3 NKT Cells License Conventional DCs In Vivo; 3.1 The In Vivo Adjuvant Effect of Activated iNKT Cells: From Tolerance to T Cell Immunity; 3.2 The Mechanism of NKT Cell-Induced DC Maturation
,
3.3 Activated iNKT Cell-Mediated DC Cross-Presentation to T Cells
Weitere Ausg.:
ISBN 9781461406129
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe ISBN 9781461406129
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
T-Lymphozyt
;
Tumor
;
Immuntherapie
DOI:
10.1007/978-1-4614-0613-6
URL:
Volltext
(lizenzpflichtig)
Bookmarklink
