Umfang:
Online-Ressource (XI, 187 p. 15 illus., 10 illus. in color, online resource)
ISBN:
9781461406624
,
1283353318
,
9781283353311
Serie:
SpringerLink
Inhalt:
The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development
Anmerkung:
Includes bibliographical references and index
,
Tumour-Associated Macrophages; Preface; Contents; Contributors; Part I: Form and Function; Chapter 1: Macrophage Phenotype in Tumours; Introduction; Macrophage Heterogeneity in Tumours; Membrane Markers for Macrophages in Tumours; EGF-TM7 Receptors and Tumour-Associated Macrophages; Common Characteristics of the EGF-TM7 Receptors; F4/80; CD97; EMR2; Conclusion; References; Chapter 2: Role of Tumour-Associated Macrophages in the Regulation of Angiogenesis; Introduction; Pro-angiogenic Functions of Macrophages in Tumours; Re-education of TAMs by Tumour-Derived Signals
,
Hypoxic Signalling and Regulation of Transcription in TAMsTIE2-Expressing Monocyte/Macrophages; Concluding Remarks; References; Chapter 3: The Role of Tumour-Associated Macrophages in Malignant Invasion; Introduction; Experimental Evidence for Macrophage-Induced Invasion; Tumour Cell-Macrophage Interactions; The Role of Resident Macrophages; Signaling in Macrophage-Induced Invasion; The EGF/CSF-1 Loop; Tumour Necrosis Factor a; The Chemokine Connection; Wnt Signaling; The Role of Proteases and the Extracellular Matrix; Conclusion; References
,
Chapter 4: Tumour-Induced Immune Suppression by Myeloid CellsTumour-Induced Immunosuppression; Tumour-Dependent Alteration in Myelopoiesis Results in Defective Accumulation of DCs and Enhanced MDSC Generation; Generation of Tumour Permissive Microenvironment; References; Chapter 5: TAM: A Moving Clinical Target; TAM and Potential Therapeutic Strategies; Macrophage Ablation; Inhibition of Monocyte Recruitment; TAM Re-education; Adoptive Transfer; Concluding Remarks; References; Part II: Mechanisms of Action; Chapter 6: Arginine Metabolism and Tumour-Associated Macrophages; Introduction
,
l -Arginine Metabolism: An Overviewl -Arginine and the Macrophage; TAMs, Cancer Cells and the Tumour Microenvironment; TAMs; Arginase; iNOS; Tumoural l -Arginine Metabolism; ASS1; iNOS and Arginase; Pharmacological Modulation of l -Arginine Metabolism in Malignancy; Targeting TAMs; Targeting l -Arginine; Conclusion; References; Chapter 7: Indoleamine 2,3-Dioxygenase Amino Acid Metabolism and Tumour-Associated Macrophages: Regulation in Cancer-Associated Inflammation and Immune Escape; Inflammatory and Immune Escape Mechanisms in the Tumour Microenvironment; Immune Escape in Cancer Progression
,
IDO in Immune Tolerance and EscapeIDO and Immune Escape in Cancer; IDO is Essential for Inflammatory Skin Carcinogenesis; IDO in Inflammation and Immune Escape in Cancer: Genetically Synonymous Pathways?; Beyond IDO: Arginine and Cysteine Deprivation in Tumoural Immune Escape; Most Cells Synthesize Cysteine or Import Cystine and Reduce it to Cysteine; During T-Cell Activation, T Cells Obtain Cysteine from APC; MDSC Prevent APC from Providing Cysteine; References; Chapter 8: Vascular Endothelial Growth Factor and Tumour-Associated Macrophages; References; Part III: Molecular Regulation
,
Chapter 9: TLR Signaling and Tumour-Associated Macrophages
Weitere Ausg.:
ISBN 9781461406617
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe ISBN 9781461406617
Sprache:
Englisch
DOI:
10.1007/978-1-4614-0662-4
URL:
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