Umfang:
Online-Ressource (XIII, 412p. 142 illus., 63 illus. in color, digital)
ISBN:
9781461410041
,
9781283353519
Serie:
Advances in Delivery Science and Technology
Inhalt:
Patrick J. Crowley
Inhalt:
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery
Anmerkung:
Includes bibliographical references and index
,
Controlled Release in OralDrug Delivery; Preface; Acknowledgements; Contents; Contributors; Chapter 1: A Short History of Controlled Drug Release and an Introduction; 1.1 Introduction; 1.1.1 Terminology of Controlled Release; 1.1.2 Oral Delivery Systems; 1.1.3 Coating as a Means to Control Drug Release; 1.1.3.1 Early Enteric Coating Materials; 1.1.3.2 Wax Coatings; 1.1.3.3 Polymer Coatings and Matrices; 1.1.3.4 Osmotic Pumps; 1.1.3.5 Ion-Exchange Resin Complexes; 1.1.4 Intramuscular and Subcutaneous Injections; 1.1.4.1 Drugs and Drug Salts; 1.1.4.2 Drug Esters; 1.1.5 Subcutaneous Implants
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1.1.6 Aerosols1.1.7 Topical Application of Drugs; 1.1.7.1 Iontophoresis; 1.1.7.2 Transdermal Patches; 1.1.7.3 Microneedles; 1.1.7.4 Hydrogels and Other Systems of Delivery to the Eye; 1.1.8 Microencapsulation; 1.1.9 Conclusions; References; Chapter 2: The Organization of the Gut and the Oral Absorption of Drugs: Anatomical, Biological and Physiological Considerations in Oral Formulation Development; 2.1 Background; 2.2 Buccal Delivery; 2.3 The Esophagus; 2.4 The Stomach; 2.4.1 Gastric pH; 2.4.2 Regulating Gastric Emptying; 2.4.3 Utilization of Upper Windows of Absorption; 2.5 The Intestine
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2.5.1 Movement of the Dosage form Along the Gut2.5.2 Intestine: Can Transit Be Modulated?; 2.6 The Colon and Drug Delivery; 2.6.1 Regional Transit Through the Colon; 2.6.2 The Gastrocolic Reflex; 2.6.3 Problems of Low Motility and a Lack of Water; 2.6.4 The Bacteria of the Colon; 2.7 Disease and Gut Transit; References; Chapter 3: Controlling Drug Release in Oral Product Development Programs: An Industrial Perspective; 3.1 Background; 3.2 Concepts and Principles; 3.3 Preclinical Studies; 3.3.1 Drug Stability on Ingestion; 3.3.2 Surmounting Enzymatic Barriers; 3.4 Phase 1 Clinical Trials
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3.4.1 Anti-Infectives3.4.2 Other Efficacy Indicators in Phase 1 Trials; 3.4.2.1 Biomarkers; 3.5 Phase 2 Clinical Trials; 3.5.1 Time, Clinical Efficacy, and Drug Delivery; 3.5.1.1 Cardiovascular Conditions; 3.5.1.2 Inflammatory Conditions; 3.5.1.3 Pulmonary Disease; 3.5.2 Dosing Frequency; 3.6 Phase 3 Clinical Trials; 3.7 Drug Repositioning; 3.7.1 Changed Disease Patterns; 3.7.2 New Indications for Established Drugs; 3.7.3 New Treatment Paradigms; 3.7.4 Drug/Drug Combinations; 3.8 Conclusions; References; Chapter 4: Animal Model Systems Suitable for Controlled Release Modeling
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4.1 Physiological Factors4.2 Intestinal Transit; 4.2.1 Gastric pH; 4.2.2 Gastric Emptying; 4.2.3 Small Intestine pH; 4.2.4 Small Intestine Transit; 4.2.5 Intestinal Microflora; 4.2.6 Intestinal Transport; 4.2.7 Intestinal Metabolism; 4.3 Animal Models; 4.3.1 Rat/Mouse; 4.3.2 Dog; 4.3.3 Cat; 4.3.4 Pig/Minipig; 4.3.5 Monkey; 4.4 Pharmacoscintigraphic Studies; 4.5 Conclusions; References; Chapter 5: In Vitro Testing of Controlled Release Dosage Forms During Development and Manufacture; 5.1 Introduction; 5.2 The Basics; 5.2.1 What Is In Vitro Drug Release Testing?
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5.2.2 How Is In Vitro Drug Release Testing Conducted?
Weitere Ausg.:
ISBN 9781461410034
Weitere Ausg.:
Buchausg. u.d.T. ISBN 9781461410034
Sprache:
Englisch
DOI:
10.1007/978-1-4614-1004-1
URL:
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