UID:
almafu_9959236134602883
Format:
1 online resource (397 p.)
Edition:
1st ed.
ISBN:
0-262-31455-X
,
0-262-31454-1
Content:
A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.ContributorsJohn Acker, Steven R.H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafo, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit
Note:
Description based upon print version of record.
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An intermediate phenotype approach to addiction genetics / James MacKillop & Marcus R. Munafò -- Electrophysiological intermediate phenotypes for the detection of genetic influences on alcoholism / Mary-Anne Enoch -- Differential metabolism of alcohol as an intermediate phenotype of risk for alcohol use disorders : alcohol and aldehyde dehydrogenase variants / Tamara L. Wall, Susan Luczak, Daria Orlowska, and Danielle Pandika -- Nicotine metabolism as an intermediate phenotype / Meghan J. Chenoweth & Rachel F. Tyndale -- Subjective responses to alcohol as an endophenotype : implications for alcoholism etiology and treatment development / Lara A. Ray & Markus Heilig -- Subjective drug effects as intermediate phenotypes for substance use / Leah M. Mayo, Abraham A. Palmer, Harriet de Wit -- Developmental considerations in gene identification efforts / Danielle M. Dick -- Enhancing addiction genetics via behavioral economic intermediate phenotypes / James MacKillop & John Acker -- Using FMRI to develop intermediate phenotypes for substance use disorders / Rachel E. Thayer & Kent E. Hutchison -- Implicit cognition : an intermediate phenotype for addiction? / Reinout W. Wiers, Thomas E. Gladwin & Eske D. Derks -- Role of genetics in addiction and the expectancy principle / Mark S. Goldman & Richard R. Reich -- Intermediate phenotypes for alcohol use and alcohol dependence : empirical findings and conceptual issues / Michael Windle -- Epigenetic effects as intermediate phenotypes / Beach, S.R.H., Gerrard, M., Brody, G.H., Simons, R.L., Kogan, S. M., Gibbons, F.X., Philibert, R.A. -- Differential sensitivity to context : GABRG1 enhances the acquisition of prototypes that serve as intermediate phenotypes for substance use / Ronald L. Simons, Man Kit Lei, Steven R.H. Beach, Gene H. Brody, Robert A. Philibert, Frederick X. Gibbons, Meg Gerrard -- From genes to behavior change : treatment response as an intermediate phenotype / Courtney J. Stevens, Hollis C. Karoly, Renee E. Magnan, and Angela D. Bryan -- Using intermediate phenotypes to bridge the gap between human and mouse genetics / Clarissa C. Parker & Abraham A. Palmer.
,
English
Additional Edition:
ISBN 0-262-01969-8
Additional Edition:
ISBN 1-306-20363-5
Language:
English
URL:
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