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  • 1
    Online Resource
    Online Resource
    Handbook of statistical methods for randomized controlled trials / (2021)
    Milton :CRC Press,
    Details
    UID:
    almafu_BV047472839
    Format: Online-Ressource (XXXIII, 62 Seiten).
    ISBN: 9781315119694
    Series Statement: Chapman and Hall/CRC Handbooks of Modern Statistical Methods Ser
    Content: Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Contents -- Preface -- List of Figures -- List of Tables -- Contributors -- I. Introduction to Randomized Controlled Trials -- 1. Introduction -- 1.1. Historical Background -- 1.2. Statistical Concepts -- 1.3. Organization of the Handbook -- Bibliography -- II. Analytic Methods for Randomized Controlled Trials -- 2. Binary and Ordinal Outcomes -- 2.1. Introduction -- 2.2. Analysis of 2 x 2 Contingency Tables -- 2.3. Analysis of R x C Contingency Tables -- 2.4. Analysis of Stratified 2 x 2 Contingency Tables -- 2.5. Regression Models for Binary Outcomes -- 2.5.1. Logistic regression -- 2.5.2. Estimation and inference for logistic regression -- 2.5.3. Exact logistic regression -- 2.5.4. Example -- 2.6. Regression Models for Ordinal Outcomes -- 2.6.1. Proportional odds model -- 2.6.2. Some alternative models for ordinal outcomes -- 2.6.3. Example -- 2.7. Adjustment for Baseline Response -- 2.8. Concluding Remarks -- Bibliography -- 3. Continuous Outcomes -- 3.1. Introduction -- 3.2. The t-Test (One Population) -- 3.3. The t-Test (Two Populations) -- 3.4. Mann-Whitney U-Test -- 3.5. Paired Tests -- 3.5.1. Paired t-test -- 3.5.2. Wilcoxon signed rank test -- 3.6. Multiple Comparisons -- 3.7. Regression -- 3.7.1. Residuals -- 3.7.2. Inference for linear regression -- 3.7.3. ANCOVA models -- 3.7.4. Nonlinear regression -- 3.8. Conclusion -- Bibliography -- 4. Time to Event Data -- 4.1. Introduction -- 4.2. ACTG 320 -- 4.3. Mathematical Fundamentals -- 4.3.1. Notation -- 4.3.2. Hazard -- 4.3.3. Censoring and observed data -- 4.4. Estimation of Survival Distribution -- 4.5. Hypothesis Testing -- 4.6. Cox Regression Model -- 4.7. Informative Censoring -- 4.8. Conclusion -- Bibliography -- 5. Count Data -- 5.1. Introduction -- 5.2. Regression Analysis of Simple Count Data
    Additional Edition: Erscheint auch als Druck-Ausgabe, hbk ISBN 978-1-4987-1464-8
    Additional Edition: Erscheint auch als Druck-Ausgabe, pbk ISBN 9781032009100
    Language: English
    Subjects: Mathematics
    RVK:
    SK 850
    Keywords: Statistische Analyse ; Experiment ; Medizin ; Medizinische Statistik ; Aufsatzsammlung ; Aufsatzsammlung
    DOI: 10.1201/9781315119694
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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    Online Access
    Open Access Request
    FU Berlin
    Charité
  • 2
    Online Resource
    Online Resource
    Handbook of statistical methods for randomized controlled trials (2019)
    [Place of publication not identified], : CHAPMAN & HALL CRC,
    Details
    UID:
    almahu_9949891073102882
    Format: 1 online resource
    ISBN: 9781498714648 , 1498714641 , 9781315119694 , 1315119692 , 9781351646000 , 1351646001 , 9781351636476 , 1351636472
    Content: Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.
    Additional Edition: Print version: ISBN 1498714625
    Additional Edition: ISBN 9781498714624
    Language: English
    Keywords: Handbooks and manuals
    URL: https://www.taylorfrancis.com/books/9781315119694
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    HU Berlin
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