UID:
almafu_9961261285202883
Umfang:
1 online resource (xiv, 393 pages) :
,
digital, PDF file(s).
Ausgabe:
First edition.
ISBN:
9781009076685
,
100907668X
,
9781009076876
,
1009076876
,
9781009057646
,
1009057642
Inhalt:
Life on earth has evolved under a consistent cycle of light and darkness caused by the earth's rotation around its axis. This has led to a 24-hour circadian system in most organisms, ranging all the way from fungi to humans. With the advent of electric light in the 19th century, cycles of light and darkness have drastically changed. Shift workers and others exposed to high levels of light at night are at increased risk of health problems, including metabolic syndrome, depression, sleep disorders, dementia, heart disease, and cancer. This book will describe how the circadian system regulates physiology and behavior and consider the important health repercussions of chronic disruption of the circadian system in our increasingly lit world. The research summarized here will interest students in psychology, biology, neuroscience, immunology, medicine, and ecology.
Anmerkung:
Title from publisher's bibliographic system (viewed on 09 Oct 2023).
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Cover -- Half-title -- Title page -- Imprints page -- Contents -- List of Contributors -- Preface -- 1 Introduction to Circadian Rhythms -- 1.1 Introduction -- 1.2 Molecular Mechanisms of the Circadian Clock -- 1.3 Circadian Rhythms Occur Throughout the Body: Extra-SCN Tissue-Specific Clocks -- 1.4 Circadian Regulation of CNS Function -- 1.5 Circadian Regulation of Cardiac Function -- 1.6 Circadian Regulation of Metabolism -- 1.7 Circadian Regulation of Immune Function -- 1.8 How Do We Disrupt the Clock? -- 1.9 Conclusions -- References -- 2 Central Clock Dynamics: Daily Timekeeping, Photic Processing, and Photoperiodic Encoding by the Suprachiasmatic Nucleus -- 2.1 Introduction -- 2.2 SCN Circadian Timekeeping -- 2.3 Circadian Photoentrainment and SCN Photic Processing -- 2.4 SCN Photoperiodic Encoding -- 2.5 Conclusions -- References -- 3 Melatonin, Light, and the Circadian System -- 3.1 Introduction -- 3.2 Melatonin Receptors -- 3.3 Modulation of Behavioral and Rhythmic Functions by Endogenous Melatonin -- 3.4 Efficacy of Melatonin-Related Analogues -- 3.5 Modulation of Functional Responses by MT[sub(1)] Inverse Agonists -- 3.6 Melatonin-Receptor Mediated Modulation of Rhythmic Behavior in Mammals -- 3.7 Discovery and Validation of Melatonin Receptor Ligands with Therapeutic Potential -- 3.8 Melatonin Receptors as Targets for Carbamate Insecticides -- 3.9 Circadian Disruption and Implications for Human Health -- Disclosure Statement -- Acknowledgments -- References -- 4 Disrupted Circadian Rhythms, Stress, and Allostatic Load -- 4.1 Introduction -- 4.2 The ''Stress'' Axis: A Brief Primer -- 4.3 Allostatic Load and Overload -- 4.4 Circadian Rhythms as Regulators of HPA Function -- 4.5 Effects of Glucocorticoids, Stress, and Allostatic Load on Circadian Rhythms and Sleep -- 4.6 Circadian Disruption and Allostatic Load.
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4.7 Summary and Conclusion -- References -- 5 Disrupted Circadian Rhythms and Mental Health -- 5.1 Introduction -- 5.2 Circadian Timekeeping in the Brain: Intrinsic Control versus Extrinsic Influence -- 5.3 Circadian Rhythm Disruption -- 5.4 Circadian Rhythm Disruption in Mood Disorders -- 5.5 Circadian Rhythm Disruption in Anxiety -- 5.6 Circadian Rhythm Disruption in Schizophrenia -- 5.7 Circadian Rhythms in Substance Use Disorders -- 5.8 Chronotherapy in Mental Health -- 5.9 Conclusions -- Acknowledgments -- References -- 6 Circadian Rhythms and Cognitive Functioning -- 6.1 Introduction -- 6.2 Implications for Circadian Timing in Learning and Memory -- 6.3 Molecular Mechanisms Underlying Circadian Control of Learning and Memory -- 6.4 Conclusions and Considerations -- Acknowledgments -- References -- 7 Circadian Rhythm Disruption in Aging and Alzheimer's Disease -- 7.1 Introduction -- 7.2 Circadian Rhythm Alterations in Aging and AD -- 7.3 Changes in the Master Circadian Pacemaker Associated with Aging and AD -- 7.4 Molecular Basis of Circadian Rhythms and Alterations during Aging -- 7.5 Role of Age-Related Changes in Clock Gene Expression on Neural Function -- 7.6 Mechanisms Underlying Age-Related Changes in Clock Gene Expression -- 7.7 Potential Strategies to Reduce Age- or AD-Related Circadian Rhythm Disruption -- 7.8 Summary and Conclusions -- References -- 8 Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury -- 8.1 Introduction -- 8.2 Circadian Rhythms Maintain Healthy Immune and Nervous Systems -- 8.3 Traumatic Brain Injury and Spinal Cord Injury: Role of Neuroinflammation -- 8.4 The Circadian-Neuroimmune Axis in Neurotrauma: Linking Circadian Cues in the External Environment to Internal Oscillators -- 8.5 The Circadian-Neuroimmune Axis in Neurotrauma: Role of the Internal Body Clock.
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8.6 Future Directions: Leveraging Chronobiologic Strategies for Enhancing Recovery after Neurotrauma -- 8.7 Conclusions -- References -- 9 Disrupted Circadian Rhythms and Neuroendocrine Function in Fertility -- 9.1 Circadian Disruption Negatively Impacts Male and Female Fertility -- 9.2 The Neuroendocrine System Regulates the Precise Timing of Hormone Release Required for Fertility -- 9.3 Circadian Disruption and the Impact on Reproductive Function: From Mice to Men -- 9.4 Conclusion -- References -- 10 Disrupted Circadian Rhythms and Metabolic Function -- 10.1 Humans -- 10.2 Non-Human Animals -- 10.3 Conclusion -- References -- 11 Disrupted Circadian Rhythms, Time Restricted Feeding, and Blood Pressure Regulation -- 11.1 Introduction -- 11.2 Timing of Food Intake Is Critical in BP Circadian Rhythm -- 11.3 Potential Mechanisms Underlying the Timing of Food Intake on BP Circadian Rhythm -- 11.4 Summary and Future Directions -- References -- 12 Disrupted Circadian Rhythms and Immune Function -- 12.1 Introduction -- 12.2 The Circadian Immune System -- 12.3 Environmental Disruption of Circadian Rhythms -- 12.4 Genetic Disruption of Circadian Rhythms -- 12.5 Inflammation as Circadian Disruption -- 12.6 Conclusion -- References -- 13 Circadian Rhythms and Cardiac Function -- 13.1 Introduction -- 13.2 Circadian Clocks in the Heart and the Effects of Circadian Disruption -- 13.3 Circadian Disruptions, Heart Attacks, and Heart Failure -- 13.4 Circadian Rhythms and Human Cardiovascular Function -- 13.5 Integrating Human and Comparative Studies: Limitations and Opportunities -- 13.6 Conclusions: Future of Chronotherapy and Cardiovascular Health -- Acknowledgments -- References -- 14 Disrupted Circadian Rhythms and Cancer -- 14.1 Introduction -- 14.2 Overview of Human Studies -- 14.3 Overview of Animal Studies.
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14.4 Exploiting the Clock in Cancer Management and Prevention -- References -- 15 Light Effects across Species in Nature: A Focus on Solutions -- 15.1 Introduction -- 15.2 Avoid -- 15.3 Minimize -- 15.4 Restore or Rehabilitate -- 15.5 Offset -- 15.6 Conclusions -- Acknowledgments -- References -- 16 Measurement and Analysis of Exposure to Light at Night in Epidemiology -- 16.1 Introduction -- 16.2 Measures of Light Exposure -- 16.3 Opportunities for Future Research -- References -- Index.
Weitere Ausg.:
ISBN 9781316512081
Weitere Ausg.:
ISBN 1316512088
Sprache:
Englisch
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