UID:
almahu_9949926904702882
Umfang:
1 online resource (771 pages)
Ausgabe:
Sixth edition.
ISBN:
1394244827
,
9781394244829
,
1394244843
,
9781394244843
,
1394244835
,
9781394244836
Inhalt:
The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests.
Anmerkung:
Cover -- Dedication page -- Title page -- Copyright page -- Contents -- Preface to the sixth edition -- Acknowledgements -- Abbreviations -- Chapter One The normal bone marrow: examining and reporting bone marrow specimens -- The distribution of haemopoietic marrow -- The organization of the bone marrow -- Bone -- Other connective tissue elements -- Haemopoietic and other cells -- Examination of the bone marrow -- Bone marrow aspiration -- Trephine biopsy of bone marrow -- Relative advantages of aspiration and core biopsy -- Other techniques -- Cellularity -- Haemopoietic and mesenchymal cells -- Erythropoiesis -- Granulopoiesis -- Monocytopoiesis -- Stromal dendritic cells -- Megakaryopoiesis and thrombopoiesis -- Mast cells -- Ostoblasts and osteoclasts -- Fat cells -- Lymphopoiesis -- Lymphocytes -- Plasma cells -- Storage and erythroblast iron -- The cellular composition of bone marrow -- Interpretation of bone marrow aspirates and trephine biopsies -- Examination of bone marrow aspirate films -- Reporting a bone marrow aspirate -- Examination of trephine biopsy sections -- Reporting trephine biopsy sections -- Guidelines, integrated reporting and audit -- Digital pathology -- Artificial intelligence and automated image analysis -- Artefacts -- References -- Chapter Two Special techniques applicable to bone marrow diagnosis -- Cytochemical and histochemical stains -- Cytochemical stains on bone marrow aspirates -- Histochemical stains on trephine biopsy sections -- Immunophenotyping -- Immunophenotyping by immunofluorescence flow cytometry -- Immunocytochemistry -- Relative advantages of flow cytometry and immunocytochemistry -- Antibodies for flow cytometry and immunocytochemistry -- Immunohistochemistry -- Cytogenetic analysis -- Molecular genetic analysis -- Fluorescence and other in situ hybridization techniques -- Southern blot analysis.
,
The polymerase chain reaction -- Reverse transcriptase polymerase chain reaction -- Modifications of PCR and RT-PCR techniques -- Microarray analysis -- Next generation sequencing -- Other molecular genetic techniques -- The application of molecular genetic techniques in the investigation of haematological neoplasms -- Ultrastructural examination -- Bone marrow culture for assessment of haemopoietic progenitor cell numbers -- Short-term culture -- Long-term culture -- Bone marrow culture for microorganisms -- References -- Chapter Three Infection and reactive changes -- Infection -- Bacterial infection -- Viral infection -- Fungal infections -- Parasitic diseases -- Bone marrow granulomas -- Reactive lymphoid infiltrates -- Plasmacytosis and cytological abnormalities in plasma cells -- Mast cells -- Histiocytosis -- Haemophagocytic syndromes -- Iron overload -- HIV infection and the acquired immune deficiency syndrome -- Blood vessels and vascular lesions -- Bone marrow necrosis -- Gelatinous transformation -- Amyloid deposition -- Bone marrow fibrosis -- References -- Chapter Four Acute myeloid leukaemia, mixed phenotype acute leukaemia, the myelodysplastic neoplasms/syndromes and histiocytic and dendritic cell neoplasms -- Acute myeloid leukaemia -- The FAB classification of acute myeloid leukaemia -- M0 AML -- M1 and M2 AML -- M3 and M3 variant AML -- M4 AML -- M5 AML -- M6 AML -- M7 AML -- The WHO classification of acute myeloid leukaemia -- Problems and pitfalls in the diagnosis of AML -- Acute leukaemia of mixed or ambiguous lineage -- The myelodysplastic neoplasms/syndromes -- The WHO and International Consensus classifications of the myelodysplastic syndromes -- Genetically defined myelodysplastic neoplasms -- Morphologically defined myelodysplastic neoplasms -- Myelodysplastic neoplasms/syndromes of childhood.
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Problems and pitfalls in the diagnosis of myelodysplastic syndromes -- Clonal cytopenia of undetermined significance and idiopathic cytopenia of unknown significance -- Histiocytic and dendritic cell neoplasms -- References -- Chapter Five Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions -- Myeloproliferative neoplasms -- Essential thrombocythaemia -- Myelodysplastic/myeloproliferative neoplasms -- References -- Chapter Six Lymphoproliferative disorders -- Bone marrow infiltration in lymphoproliferative disorders -- B-lineage lymphomas and leukaemias -- B-lymphoblastic leukaemia/lymphoma -- Chronic lymphocytic leukaemia/small lymphocytic lymphoma -- Monoclonal B-cell lymphocytosis -- B-cell prolymphocytic leukaemia -- Hairy cell leukaemia -- Lymphoplasmacytic lymphoma -- IgM monoclonal gammopathy of undetermined significance -- Heavy chain diseases -- Follicular lymphoma -- Primary cutaneous follicle centre cell lymphoma -- Mantle cell lymphoma -- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and other marginal zone lymphomas -- Splenic marginal zone lymphoma -- Nodal marginal zone B-cell lymphoma -- Splenic diffuse red pulp small B-cell lymphoma -- Splenic B-cell lymphoma/leukaemia with prominent nucleoli/hairy cell leukaemia variant -- Diffuse large B-cell lymphoma and other large B-cell lymphomas -- Kaposi sarcoma herpesvirus/human herpesvirus 8-positive lymphomas -- Lymphoid proliferations and lymphomas associated with immune deficiency/dysregulation -- Burkitt lymphoma -- Lymphoproliferative disorders of T lineage and natural killer (NK) lineage -- T-lymphoblastic leukaemia/lymphoma, nos -- Early T-precursor acute lymphoblastic leukaemia/lymphoma -- NK-lymphoblastic leukaemia/lymphoma -- T-cell prolymphocytic leukaemia.
,
T-cell large granular lymphocytic leukaemia -- NK large granular lymphocytic leukaemia/chronic lymphoproliferative disorder of NK lineage -- Aggressive NK-cell leukaemia -- Ebv-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood/EBV-positive T-cell and NK-cell lymphoproliferative disorders of childhood -- Extranodal NK/T-cell lymphoma/extranodal NK/T-cell lymphoma, nasal type -- Sézary syndrome -- Mycosis fungoides -- Subcutaneous panniculitis-like T-cell lymphoma -- Primary cutaneous gamma-delta T-cell lymphoma -- Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic Tcell lymphoma) -- Adult T-cell leukaemia/lymphoma -- Hepatosplenic T-cell lymphoma -- Anaplastic large cell lymphoma, ALK-positive -- Anaplastic large cell lymphoma, ALK-negative -- Enteropathy-associated T-cell lymphoma -- Monomorphic epitheliotropic intestinal T-cell lymphoma -- Breast-implant-associated anaplastic large cell lymphoma -- Peripheral T-cell lymphoma, not otherwise specified -- Hodgkin lymphoma -- Post-transplant and other immunodeficiency-associated lymphoproliferative disorders and their relationship to the epstein-barr virus -- References -- Chapter Seven Plasma cell neoplasms and related conditions -- Plasma cell neoplasm -- Plasma cell myeloma/multiple myeloma -- Plasma cell leukaemia -- Non-IgM monoclonal gammopathy of undetermined significance -- Lymphoplasmacytic neoplasms -- IgM monoclonal gammopathy of undetermined significance (IgM MGUS) -- Waldenström macroglobulinaemia -- Other syndromes associated with secretion of a paraprotein -- Immunoglobulin-related (AL) amyloidosis -- Monoclonal immunoglobulin deposition diseases/light chain and heavy chain deposition diseases -- Essential and other paraprotein-associated cryoglobulinaemia -- Cold haemagglutinin disease -- Alpha heavy chain disease.
,
Gamma heavy chain disease -- Mu heavy chain disease -- The POEMS syndrome -- The TEMPI syndrome -- The AESOP syndrome -- Acquired angio-oedema associated with plasma cell neoplasia -- References -- Chapter Eight Disorders of erythropoiesis, granulopoiesis and thrombopoiesis -- Disorders of red cells -- Iron deficiency anaemia -- Sideroblastic anaemia -- Thalassaemia trait and thalassaemia intermedia -- Thalassaemia major -- Haemoglobin H disease -- Haemolytic anaemias -- Congenital dyserythropoietic anaemia -- Megaloblastic anaemia -- Anaemia of chronic disease -- Sickle cell disease -- Pure red cell aplasia (including Blackfan-Diamond syndrome) -- Polycythaemia -- Disorders of leucocytes -- Congenital neutropenia -- Inherited and other constitutional neutrophilia -- Jordans anomaly -- Pelger-huët anomaly -- Agranulocytosis -- Other drug-induced neutropenia -- Autoimmune neutropenia -- Idiopathic hypereosinophilic syndrome -- Chédiak-Higashi syndrome -- Disorders of platelets -- Congenital thrombocytopenia -- Acquired thrombocytopenias -- Familial thrombocytosis -- Reactive thrombocytosis -- References -- Chapter Nine Miscellaneous disorders -- Non-metastatic effects of cancer -- Bone marrow dysplasia with polyclonal haemopoiesis -- The bone marrow in connective tissue and autoimmune disorders -- Congenital immune deficiency syndromes -- Autoimmune lymphoproliferative syndrome -- The haematological effects of anti-cancer and immunosuppressive chemotherapy -- The haematological effects of other drugs and chemicals -- The effect of irradiation on the bone marrow -- The haematological effects of alcohol -- Aplastic anaemia -- Other causes of bone marrow aplasia and hypoplasia -- Pearson syndrome and other mitochondrial cytopathies -- Other constitutional abnormalities associated with abnormal haemopoiesis -- Paroxysmal nocturnal haemoglobinuria.
Sprache:
Englisch
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394244843
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394244843
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