UID:
almafu_9961606400402883
Umfang:
1 online resource (399 p.).
ISBN:
9781394300808
,
1394300808
,
9781394300785
,
1394300786
Serie:
Sciences. Biology. Molecular, structural and biochemical biology
Anmerkung:
5.6. Telomeres, replicative senescence, aging and genomic instability
,
Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Chapter 1. Telomeres: All's Well That Ends Well -- 1.1. Introduction -- 1.2. The beginning of the end -- 1.2.1. Chemists and biophysicists at work: G-quartets and G-quadruplexes disclose themselves -- 1.2.2. Biologists at work: telomeres disclose themselves -- 1.2.3. When and where G-quadruplexes and telomeres met -- 1.3. Telomeric architectures: from ciliates to other eukaryotes -- 1.3.1. Telomeric DNA and telomeric proteins -- 1.3.2. Telomeric structures -- 1.4. G-quadruplexes at telomeres
,
1.4.1. Secondary structures formed by repeats of telomeric motifs -- 1.4.2. G4s at telomeres: friendly or unfriendly structures? -- 1.5. References -- Chapter 2. Methods to Measure Telomere Lengths -- 2.1. Why does telomere length matter? -- 2.2. Methods for measuring telomere length -- 2.2.1. Terminal restriction fragment analysis (TRF) -- 2.2.2. Single telomere length analysis -- 2.2.3. Telomere shortest length assay -- 2.2.4. Quantitative-polymerase chain reaction -- 2.2.5. Quantitative-fluorescence in situ hybridization -- 2.2.6. Flow-fluorescence in situ hybridization -- 2.3. References
,
Chapter 3. The Shelterin Complex -- 3.1. TRF1 and TRF2, structurally alike but... -- 3.1.1. Domains organization -- 3.1.2. Biological roles -- 3.2. RAP1 -- 3.3. TIN2 -- 3.4. TPP1-POT1 -- 3.5. Quaternary structure of the shelterin -- 3.6. Concluding remarks -- 3.7. References -- Chapter 4. Mammalian Telomere Organization and Dynamics in the Nuclear Volume -- 4.1. Introduction -- 4.2. Nuclear envelope and lamins: orchestrators of cell and genome architecture -- 4.2.1. The nuclear envelope landmarks -- 4.2.2. The nuclear envelope as a scaffold to organize nuclear architecture
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4.2.3. Nuclear envelope disassembly during mitosis -- 4.3. Interplay between telomeres and nuclear structures -- 4.4. Telomere tethering to the NE to promote meiotic pairing -- 4.5. Telomere organization and dynamics in the nucleus -- 4.6. Interaction between telomere chromatin and lamins during post-mitotic nuclear assembly -- 4.7. Interaction between telomere chromatin and lamins for telomere maintenance -- 4.8. Conclusion -- 4.9. References -- Chapter 5. Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology -- 5.1. Introduction
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5.2. Telomere characterization: various experimental organisms for first historical experiments -- 5.3. Protection and proliferation: the telomere dilemma -- 5.3.1. Telomeric sequences: pattern conservation and length variations -- 5.3.2. Telomeric proteins -- 5.3.3. TERRA or telomere transcription -- 5.4. Telomere maintenance -- 5.4.1. The difficulties of moving replication fork through telomeres -- 5.4.2. The end replication problem -- 5.4.3. Telomerase: a solution to the problem of telomere shortening -- 5.5. Telomeres: one size for one identity
Weitere Ausg.:
Print version: Saintome, Carole Telomeres Newark : John Wiley & Sons, Incorporated,c2024 ISBN 9781789450972
Sprache:
Englisch
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394300808
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394300808
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781394300808
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