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  • 1
  • 2
    Online-Ressource
    Online-Ressource
    Hoboken, N.J. :Wiley,
    UID:
    almafu_9959328613902883
    Umfang: 1 online resource
    ISBN: 9781118433041 , 1118433041 , 9781118433027 , 1118433025 , 9781118433003 , 1118433009 , 9781118433034 , 1118433033 , 9780470610756 , 0470610751 , 9781283645270 , 1283645270
    Inhalt: "This book details the current and future tools used in the production of bulk chemicals and biofuels developed from renewable biomass using green technologies. It describes in depth the technology used to unravel the complexity of microbial metabolism in order to produce engineering strains at time scales much faster than would occur naturally. It also highlights the advantages and drawbacks of all methods and tools used in multiple disciplines for genome engineering of complex phenotypes. Case-study examples on applying the tools reinforce the fundamental concepts. A must for research and development biochemists and engineers"--
    Anmerkung: Machine generated contents note: Foreword John Pierce PREFACE Ranjan Patnaik CHAPTER 1 Classical Strain Engineering Nathan Crook and Hal Alper CHAPTER 2 Tracer-based Analysis of Metabolic Flux Networks Michael Dauner CHAPTER 3 Integration of 'Omics' Data with Genome-scale Metabolic Models Stephen Van Dien, Priti Pharkya, and Robin Osterhout CHAPTER 4 Strain Improvement via Evolutionary Engineering Byoungjin Kim, Jing Du, and Huimin Zhao CHAPTER 5 Rapid Fermentation Process Development and Optimization Jun Sun and Lawrence Chew CHAPTER 6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives Bert Koekman and Marcus Hans CHAPTER 7 Metabolic Engineering of recombinant E. coli for the Production of 3-Hydroxypropionate Tanya Warnecke Lipscomb, Matthew L. Lipscomb, and Michael D. Lynch CHAPTER 8 Complex System Engineering: A Case Study for an Unsequenced Microalga Michael Guarnieri, Yat-Chen Chou, Bryon S. Donohoe, Eric Knoshaug, Lieve Laurens and Phillip T. Pienkos CHAPTER 9 Meiotic Recombination-based genome shuffling of Saccharomyces cerevisiae and Schefferomyces stiptis for increased inhibitor tolerance to lignocellulosic substrate toxicity Dominic Pinel and Vincent J.J. Martin. , TITLE PAGE; COPYRIGHT PAGE; FOREWORD; PREFACE; CONTRIBUTORS; 1 CLASSICAL STRAIN IMPROVEMENT; 1.0 INTRODUCTION; 1.1 THE APPROACH DEFINED; 1.2 MUTAGENESIS; 1.3 GENOTYPIC LANDSCAPES; 1.4 SCREENING; 1.5 CONCLUSIONS; 2 TRACER-BASED ANALYSIS OF METABOLIC FLUX NETWORKS; 2.0 INTRODUCTION; 2.1 SETTING UP A STOICHIOMETRIC NETWORK MODEL; 2.2 SMALL-SCALE MODELS VERSUS GENOME SCALE MODELS; 2.3 NETWORK ANALYSIS: MAXIMUM THEORETICAL YIELD; 2.4 (STOICHIOMETRIC) METABOLIC FLUX ANALYSIS; 2.5 CARRYING OUT A LABELING EXPERIMENT; 2.6 MEASURING ISOTOPE LABELING PATTERNS; 2.7 TRACER-BASED MFA. , 2.8 VALIDATING METABOLIC FLUX NETWORKS2.9 CONCLUSIONS; ACKNOWLEDGMENTS; 3 INTEGRATION OF "OMICS" DATA WITH GENOME-SCALE METABOLIC MODELS; 3.0 INTRODUCTION; 3.1 GENOME-SCALE METABOLIC NETWORKS; 3.2 CONSTRAINT-BASED MODELING THEORY; 3.3 CURRENT ANALYSIS OF OMICS DATA; 3.4 NEW APPROACHES TO DEVELOPING MODEL CONSTRAINTS; 3.5 USE OF GENE EXPRESSION DATA IN METABOLIC MODELS; 3.6 USE OF METABOLOMICS DATA IN METABOLIC MODELS: TMFA EXAMPLE; 3.7 INTEGRATION OF MULTIPLE OMICS DATA SETS; 3.8 FUTURE DIRECTIONS AND APPLICATIONS TO STRAIN ENGINEERING; 4 STRAIN IMPROVEMENT VIA EVOLUTIONARY ENGINEERING. , 4.0 INTRODUCTION4.1 METHODOLOGIES FOR EVOLUTIONARY ENGINEERING; 4.2 EXAMPLES OF EVOLUTIONARY ENGINEERING; 4.3 CONCLUSIONS AND FUTURE PROSPECTS; ACKNOWLEDGMENTS; 5 RAPID FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION; 5.0 INTRODUCTION; 5.1 OVERVIEW OF CLASSICAL FERMENTATION PROCESS DEVELOPMENT METHODOLOGY; 5.2 FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION; 5.3 RAPID PROCESS DEVELOPMENT AND OPTIMIZATION USING CONVENTIONAL FERMENTATION SYSTEM; 5.4 STRAIN EVALUATION AND PROCESS OPTIMIZATION UNDER SCALE-DOWN CONDITIONS; 5.5 CONTROL AND SENSOR TECHNOLOGIES FOR MINIBIOREACTOR. , 5.6 COMMERCIAL HIGH-THROUGHPUT FERMENTATION SYSTEMS5.7 TRENDS IN DEVELOPMENT OF HIGH THE GREATA-THROUGHPUT MINIBIOREACTOR SYSTEM; 5.8 CASE STUDIES OF FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION USING HIGH-THROUGHPUT MINIBIOREACTORS; 5.9 CONCLUSIONS AND THE PATH FORWARD; 6 THE CLAVULANIC ACID STRAIN IMPROVEMENT PROGRAM AT DSM ANTI-INFECTIVES; 6.0 INTRODUCTION; 6.1 THE BIOSYNTHETIC PATHWAY TO CLAVULANIC ACID; 6.2 THE STRATEGY FOR IMPROVEMENT OF MULTIPLE COMPLEX PHENOTYPES; 6.3 RESULTS AND DISCUSSION; 6.4 FUTURE PERSPECTIVES; ACKNOWLEDGMENTS. , 7 METABOLIC ENGINEERING OF RECOMBINANT E. COLI FOR THE PRODUCTION OF 3-HYDROXYPROPIONATE7.0 INTRODUCTION TO BIOSYNTHESIS OF 3-HYDROXYPROPIONIC ACID; 7.1 ORGANIC ACID TOXICITY; 7.2 UNDERSTANDING 3-HP TOXICITY; 7.3 STRAIN DESIGN; 7.4 COMBINING 3-HP TOLERANCE AND 3-HP PRODUCTION; 7.5 SUMMARY; 8 COMPLEX SYSTEM ENGINEERING: A CASE STUDY FOR AN UNSEQUENCED MICROALGA; 8.0 HISTORICAL PERSPECTIVE; 8.1 ANALYSIS OF ALGAL BIOMASS COMPOSITION; 8.2 DEVELOPMENT OF HYPOTHESIS-DRIVEN STRAIN IMPROVEMENT STRATEGIES; 8.3 IMPLEMENTATION OF BIOLOGICAL TOOLS I- DEVELOPMENT OF A TRANSFORMATION SYSTEM.
    Weitere Ausg.: Print version: Engineering complex phenotypes in industrial strains. Hoboken, N.J. : Wiley, 2012 ISBN 9781405192750
    Sprache: Englisch
    Schlagwort(e): Electronic books. ; Electronic books. ; Electronic books.
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Online-Ressource
    Online-Ressource
    Chichester, West Sussex, UK ; : Wiley-Blackwell,
    UID:
    almafu_9959328614102883
    Umfang: 1 online resource
    ISBN: 9781118305447 , 1118305442 , 9781118305423 , 1118305426 , 9781118305430 , 1118305434 , 9781118305454 , 1118305450 , 1405192755 , 9781405192750 , 9781405192743 , 1405192747
    Inhalt: Filling a niche in the geomorphology teaching market, this introductory book is built around a 12 week course in fluvial geomorphology. 'Reading the landscape' entails making sense of what a riverscape looks like, how it works, how it has evolved over time, and how alterations to one part of a catchment may have secondary consequences elsewhere, over different timeframes. These place-based field analyses are framed within their topographic, climatic and environmental context. Issues and principles presented in the first part of this book provide foundational understandings tha.
    Anmerkung: COMPANION WEBSITE -- Title page -- Copyright page -- Dedication -- Preface -- Purpose and aims of this book -- Structure of the book -- Acknowledgements -- CHAPTER ONE: Geomorphic analysis of river systems: an approach to reading the landscape -- Introduction -- How is geomorphology useful? -- Geomorphic analysis of river systems: our approach to reading the landscape -- Key messages from this chapter -- CHAPTER TWO: Key concepts in river geomorphology -- Introduction -- Spatial considerations in reading the landscape , Catchment linkages and (dis)connectivityConceptualisation of time -- Differentiating behaviour from change -- Disturbance events -- Magnitudeâ€"frequency relationships in river systems -- River sensitivity and resilience -- Catchment-specific analysis of river systems: combining spatial and temporal concepts -- Conclusion -- Key messages from this chapter -- CHAPTER THREE: Catchment-scale controls on river geomorphology -- Introduction: what is a catchment? -- Process zones in catchments: sediment source, transfer and accumulation zones , Longitudinal profiles of riversGeomorphic transitions along river longitudinal profiles -- Catchment morphometrics as controls on river character and behaviour -- Geologic controls on drainage network form, and river character and behaviour -- The influence of catchment configuration upon flow and sediment flux -- Conclusion -- Key messages from this chapter -- CHAPTER FOUR: Catchment hydrology -- Introduction: what is hydrology? -- The hydrological cycle -- Operation of the hydrological cycle -- Runoff generation -- Groundwater flows , Catchment-scale runoff and discharge generation modelsChannel initiation -- Gully and channel formation -- Flow regimes of perennial, intermittent and ephemeral rivers -- Discharge and the magnitude/frequency of flow in river systems -- Flood stages and hydrographs -- Analysis of hydrograph shape -- Discharge measurement -- Flow frequency -- Flow variability -- Conclusion -- Key messages from this chapter -- CHAPTER FIVE: Impelling and resisting forces in river systems -- Introduction , Impelling and resisting forces and Laneâ€"! balance of erosion and deposition in channelsMechanics of fluid flow -- Impelling forces in river channels -- Resisting forces in channels -- Vegetation and wood as resistance elements in river systems -- Manningâ€"! n as a unifying roughness parameter -- The balance of impelling and resisting forces along longitudinal profiles -- Conclusion -- Key messages from this chapter -- CHAPTER SIX: Sediment movement and deposition in river systems -- Introduction
    Weitere Ausg.: Print version: Fryirs, Kirstie A. Geomorphic analysis of river systems. Chichester, West Sussex, UK ; Hoboken, NJ : Wiley, 2013 ISBN 9781405192750
    Sprache: Englisch
    Schlagwort(e): Electronic books. ; Electronic books. ; Electronic books.
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Online-Ressource
    Online-Ressource
    Hoboken, N.J. :Wiley,
    UID:
    almahu_9948197854002882
    Umfang: 1 online resource
    ISBN: 9781118433041 , 1118433041 , 9781118433027 , 1118433025 , 9781118433003 , 1118433009 , 9781118433034 , 1118433033 , 9780470610756 , 0470610751 , 9781283645270 , 1283645270
    Inhalt: "This book details the current and future tools used in the production of bulk chemicals and biofuels developed from renewable biomass using green technologies. It describes in depth the technology used to unravel the complexity of microbial metabolism in order to produce engineering strains at time scales much faster than would occur naturally. It also highlights the advantages and drawbacks of all methods and tools used in multiple disciplines for genome engineering of complex phenotypes. Case-study examples on applying the tools reinforce the fundamental concepts. A must for research and development biochemists and engineers"--
    Anmerkung: Machine generated contents note: Foreword John Pierce PREFACE Ranjan Patnaik CHAPTER 1 Classical Strain Engineering Nathan Crook and Hal Alper CHAPTER 2 Tracer-based Analysis of Metabolic Flux Networks Michael Dauner CHAPTER 3 Integration of 'Omics' Data with Genome-scale Metabolic Models Stephen Van Dien, Priti Pharkya, and Robin Osterhout CHAPTER 4 Strain Improvement via Evolutionary Engineering Byoungjin Kim, Jing Du, and Huimin Zhao CHAPTER 5 Rapid Fermentation Process Development and Optimization Jun Sun and Lawrence Chew CHAPTER 6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives Bert Koekman and Marcus Hans CHAPTER 7 Metabolic Engineering of recombinant E. coli for the Production of 3-Hydroxypropionate Tanya Warnecke Lipscomb, Matthew L. Lipscomb, and Michael D. Lynch CHAPTER 8 Complex System Engineering: A Case Study for an Unsequenced Microalga Michael Guarnieri, Yat-Chen Chou, Bryon S. Donohoe, Eric Knoshaug, Lieve Laurens and Phillip T. Pienkos CHAPTER 9 Meiotic Recombination-based genome shuffling of Saccharomyces cerevisiae and Schefferomyces stiptis for increased inhibitor tolerance to lignocellulosic substrate toxicity Dominic Pinel and Vincent J.J. Martin. , TITLE PAGE; COPYRIGHT PAGE; FOREWORD; PREFACE; CONTRIBUTORS; 1 CLASSICAL STRAIN IMPROVEMENT; 1.0 INTRODUCTION; 1.1 THE APPROACH DEFINED; 1.2 MUTAGENESIS; 1.3 GENOTYPIC LANDSCAPES; 1.4 SCREENING; 1.5 CONCLUSIONS; 2 TRACER-BASED ANALYSIS OF METABOLIC FLUX NETWORKS; 2.0 INTRODUCTION; 2.1 SETTING UP A STOICHIOMETRIC NETWORK MODEL; 2.2 SMALL-SCALE MODELS VERSUS GENOME SCALE MODELS; 2.3 NETWORK ANALYSIS: MAXIMUM THEORETICAL YIELD; 2.4 (STOICHIOMETRIC) METABOLIC FLUX ANALYSIS; 2.5 CARRYING OUT A LABELING EXPERIMENT; 2.6 MEASURING ISOTOPE LABELING PATTERNS; 2.7 TRACER-BASED MFA. , 2.8 VALIDATING METABOLIC FLUX NETWORKS2.9 CONCLUSIONS; ACKNOWLEDGMENTS; 3 INTEGRATION OF "OMICS" DATA WITH GENOME-SCALE METABOLIC MODELS; 3.0 INTRODUCTION; 3.1 GENOME-SCALE METABOLIC NETWORKS; 3.2 CONSTRAINT-BASED MODELING THEORY; 3.3 CURRENT ANALYSIS OF OMICS DATA; 3.4 NEW APPROACHES TO DEVELOPING MODEL CONSTRAINTS; 3.5 USE OF GENE EXPRESSION DATA IN METABOLIC MODELS; 3.6 USE OF METABOLOMICS DATA IN METABOLIC MODELS: TMFA EXAMPLE; 3.7 INTEGRATION OF MULTIPLE OMICS DATA SETS; 3.8 FUTURE DIRECTIONS AND APPLICATIONS TO STRAIN ENGINEERING; 4 STRAIN IMPROVEMENT VIA EVOLUTIONARY ENGINEERING. , 4.0 INTRODUCTION4.1 METHODOLOGIES FOR EVOLUTIONARY ENGINEERING; 4.2 EXAMPLES OF EVOLUTIONARY ENGINEERING; 4.3 CONCLUSIONS AND FUTURE PROSPECTS; ACKNOWLEDGMENTS; 5 RAPID FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION; 5.0 INTRODUCTION; 5.1 OVERVIEW OF CLASSICAL FERMENTATION PROCESS DEVELOPMENT METHODOLOGY; 5.2 FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION; 5.3 RAPID PROCESS DEVELOPMENT AND OPTIMIZATION USING CONVENTIONAL FERMENTATION SYSTEM; 5.4 STRAIN EVALUATION AND PROCESS OPTIMIZATION UNDER SCALE-DOWN CONDITIONS; 5.5 CONTROL AND SENSOR TECHNOLOGIES FOR MINIBIOREACTOR. , 5.6 COMMERCIAL HIGH-THROUGHPUT FERMENTATION SYSTEMS5.7 TRENDS IN DEVELOPMENT OF HIGH THE GREATA-THROUGHPUT MINIBIOREACTOR SYSTEM; 5.8 CASE STUDIES OF FERMENTATION PROCESS DEVELOPMENT AND OPTIMIZATION USING HIGH-THROUGHPUT MINIBIOREACTORS; 5.9 CONCLUSIONS AND THE PATH FORWARD; 6 THE CLAVULANIC ACID STRAIN IMPROVEMENT PROGRAM AT DSM ANTI-INFECTIVES; 6.0 INTRODUCTION; 6.1 THE BIOSYNTHETIC PATHWAY TO CLAVULANIC ACID; 6.2 THE STRATEGY FOR IMPROVEMENT OF MULTIPLE COMPLEX PHENOTYPES; 6.3 RESULTS AND DISCUSSION; 6.4 FUTURE PERSPECTIVES; ACKNOWLEDGMENTS. , 7 METABOLIC ENGINEERING OF RECOMBINANT E. COLI FOR THE PRODUCTION OF 3-HYDROXYPROPIONATE7.0 INTRODUCTION TO BIOSYNTHESIS OF 3-HYDROXYPROPIONIC ACID; 7.1 ORGANIC ACID TOXICITY; 7.2 UNDERSTANDING 3-HP TOXICITY; 7.3 STRAIN DESIGN; 7.4 COMBINING 3-HP TOLERANCE AND 3-HP PRODUCTION; 7.5 SUMMARY; 8 COMPLEX SYSTEM ENGINEERING: A CASE STUDY FOR AN UNSEQUENCED MICROALGA; 8.0 HISTORICAL PERSPECTIVE; 8.1 ANALYSIS OF ALGAL BIOMASS COMPOSITION; 8.2 DEVELOPMENT OF HYPOTHESIS-DRIVEN STRAIN IMPROVEMENT STRATEGIES; 8.3 IMPLEMENTATION OF BIOLOGICAL TOOLS I- DEVELOPMENT OF A TRANSFORMATION SYSTEM.
    Weitere Ausg.: Print version: Engineering complex phenotypes in industrial strains. Hoboken, N.J. : Wiley, 2012 ISBN 9781405192750
    Sprache: Englisch
    Schlagwort(e): Electronic books.
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Online-Ressource
    Online-Ressource
    Chichester, West Sussex, UK ; : Wiley-Blackwell,
    UID:
    almahu_9948197854102882
    Umfang: 1 online resource
    ISBN: 9781118305447 , 1118305442 , 9781118305423 , 1118305426 , 9781118305430 , 1118305434 , 9781118305454 , 1118305450 , 1405192755 , 9781405192750 , 9781405192743 , 1405192747
    Inhalt: Filling a niche in the geomorphology teaching market, this introductory book is built around a 12 week course in fluvial geomorphology. 'Reading the landscape' entails making sense of what a riverscape looks like, how it works, how it has evolved over time, and how alterations to one part of a catchment may have secondary consequences elsewhere, over different timeframes. These place-based field analyses are framed within their topographic, climatic and environmental context. Issues and principles presented in the first part of this book provide foundational understandings tha.
    Anmerkung: ""COMPANION WEBSITE""; ""Title page""; ""Copyright page""; ""Dedication""; ""Preface""; ""Purpose and aims of this book""; ""Structure of the book""; ""Acknowledgements""; ""CHAPTER ONE: Geomorphic analysis of river systems: an approach to reading the landscape""; ""Introduction""; ""How is geomorphology useful?""; ""Geomorphic analysis of river systems: our approach to reading the landscape""; ""Key messages from this chapter""; ""CHAPTER TWO: Key concepts in river geomorphology""; ""Introduction""; ""Spatial considerations in reading the landscape"" , ""Catchment linkages and (dis)connectivity""""Conceptualisation of time""; ""Differentiating behaviour from change""; ""Disturbance events""; ""Magnitudeâ€"frequency relationships in river systems""; ""River sensitivity and resilience""; ""Catchment-specific analysis of river systems: combining spatial and temporal concepts""; ""Conclusion""; ""Key messages from this chapter""; ""CHAPTER THREE: Catchment-scale controls on river geomorphology""; ""Introduction: what is a catchment?""; ""Process zones in catchments: sediment source, transfer and accumulation zones"" , ""Longitudinal profiles of rivers""""Geomorphic transitions along river longitudinal profiles""; ""Catchment morphometrics as controls on river character and behaviour""; ""Geologic controls on drainage network form, and river character and behaviour""; ""The influence of catchment configuration upon flow and sediment flux""; ""Conclusion""; ""Key messages from this chapter""; ""CHAPTER FOUR: Catchment hydrology""; ""Introduction: what is hydrology?""; ""The hydrological cycle""; ""Operation of the hydrological cycle""; ""Runoff generation""; ""Groundwater flows"" , ""Catchment-scale runoff and discharge generation models""""Channel initiation""; ""Gully and channel formation""; ""Flow regimes of perennial, intermittent and ephemeral rivers""; ""Discharge and the magnitude/frequency of flow in river systems""; ""Flood stages and hydrographs""; ""Analysis of hydrograph shape""; ""Discharge measurement""; ""Flow frequency""; ""Flow variability""; ""Conclusion""; ""Key messages from this chapter""; ""CHAPTER FIVE: Impelling and resisting forces in river systems""; ""Introduction"" , ""Impelling and resisting forces and Lane’s balance of erosion and deposition in channels""""Mechanics of fluid flow""; ""Impelling forces in river channels""; ""Resisting forces in channels""; ""Vegetation and wood as resistance elements in river systems""; ""Manning’s n as a unifying roughness parameter""; ""The balance of impelling and resisting forces along longitudinal profiles""; ""Conclusion""; ""Key messages from this chapter""; ""CHAPTER SIX: Sediment movement and deposition in river systems""; ""Introduction""
    Weitere Ausg.: Print version: Fryirs, Kirstie A. Geomorphic analysis of river systems. Chichester, West Sussex, UK ; Hoboken, NJ : Wiley, 2013 ISBN 9781405192750
    Sprache: Englisch
    Schlagwort(e): Electronic books.
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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