Umfang:
Online-Ressource (XVI, 243p. 63 illus., 57 illus. in color, digital)
ISBN:
9781461400400
Serie:
SpringerLink
Inhalt:
Q. Max Guo
Inhalt:
The World Health Organization has identified chronic alcohol consumption as one of the top ten risk factors for worldwide burden of disease. The International Agency for Research on Cancer has identified alcohol as carcinogenic to humans, including cancers of the upper aerodigestive tract, colon, liver and breast. Alcohol's actions may be direct e.g. effects on retinoic acid and one-carbon metabolism, or indirect, through metabolites such as acetaldehyde and reactive oxygen species or through various signaling pathways that influence cell cycle and apoptosis that may contribute to carcinogenes
Anmerkung:
Includes bibliographical references and index
,
Alcohol and Cancer; Preface; Contents; About the Contributors; Contributors; Chapter 1: Alcohol as a Human Carcinogen; Outline of an IARC Working Group Evaluation; Classification of Alcohol as a Human Carcinogen: IARC; Carcinogen Classification of Alcohol and Acetaldehyde in the USA; Conclusion; References; Chapter 2: Cancer and Alcohol: An Overview of Tumorigenesis; Introduction; Multistep Process of Tumorigenesis; Cancer Genes and the Significance of Mutations; Stepwise Model for Colorectal Cancer; Acquired Capabilities of Cancer Cells; The Hallmarks of Cancer
,
Molecular Bases of Cancer HallmarksConceptual Oncogenesis: Hallmarks Revised; Cancer and Alcohol; References; Chapter 3: Alcohol and Cancer Epidemiology; Introduction; Upper Aerodigestive Tract Cancers; Hepatocellular Carcinoma; Breast Cancer; Pancreatic Ductal Adenocarcinoma; Colorectal Cancer; Lung Cancer; Prostate Cancer; Stomach Cancer; Thyroid Cancer (Alcohol Lowers the Risk); Estimating Alcohol's Impact on Cancer Mortality in the USA; Summary; References; Chapter 4: Alcohol Metabolism and Its Implications for Cancer; Introduction; Metabolism of Ethanol to Acetaldehyde
,
Metabolism of Ethanol to Acetaldehyde by Alcohol DehydrogenaseCytochrome P450 Enzymes; Microbial Alcohol Metabolism; Oral Cavity; Sidebar 1: Genes for Alcohol Metabolism; Interactions with Smoking; Microbial Ethanol Metabolism in the Colon; Acetaldehyde Metabolism; The Inactive ALDH2 Allele and Alcohol-Related Cancer; Effect of Binge Drinking; Changes in Alcohol Metabolism in Tumors; Physiological Acetaldehyde Concentrations; The Role of Acetaldehyde in Alcohol-Related Cancer; Conflicting Epidemiological Data; Squamous Cell Carcinoma of the Esophagus; Other UADT Sites; Breast Cancer
,
Liver CancerConclusion; Mechanisms of Acetaldehyde Carcinogenicity; Acetaldehyde-DNA Adduct Formation; Hyperregeneration; CYP2E1, ROS, and Oxidative Stress; CYP2E1 and Oxidative Stress; Redox Balance; Oxidative Stress in Carcinogenesis; Adduct Formation; Changes in NADH/NAD + Levels and Gene Activation; Conversion of Procarcinogens to Carcinogens; Folate Cycle: Global Hypomethylation, Focal Hypermethylation, and Epigenetics; Sidebar 2: Methyl Group Transfers and Pancreatic Cancer; Retinol and Impairment of Other Metabolic Processes; Conclusions and New Directions; References
,
Chapter 5: Epigenetics, Alcohol, and CancerIntroduction; DNA Methylation; DNA Methylation and Cancer; Alcohol and DNA Methylation; Effects of Alcohol on the Availability and Transfer of Methyl Groups; Histone Modification; Histone Modifications and Cancer; Alteration of Histone Modification by Alcohol; MicroRNAs; MicroRNAs and Cancer; Effect of Ethanol on miRNA Expression and Function; Future Directions; Sidebar 1: CpG Island; References; Chapter 6: Alcohol, Cancer Genes, and Signaling Pathways; Introduction; Alcohol and Mitogenic Signals; MAPK Pathway; RAS; Estrogen Signaling
,
Alcohol and Insensitivity to Antigrowth Signals
Weitere Ausg.:
ISBN 9781461400394
Weitere Ausg.:
Buchausg. u.d.T. Alcohol and cancer New York, NY [u.a.] : Springer, 2011 ISBN 9781461400394
Weitere Ausg.:
ISBN 1461400392
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Alkohol
;
Carcinogenität
;
Alkohol
;
Carcinogenese
DOI:
10.1007/978-1-4614-0040-0
URL:
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