Umfang:
Online-Ressource (XXV, 598p. 106 illus., 37 illus. in color, digital)
ISBN:
9781461410256
Serie:
SpringerLink
Inhalt:
The selenium field has grown dramatically in the years since the first edition of Selenium: Its Molecular Biology and Role in Human Health was published in 2001. All aspects of selenium biology have advanced with many new approaches and insights into the biochemical, molecular, genetic, and health areas of this intriguing element.¡The third edition of Selenium: Its Molecular Biology and Role in Human Health brings readers up to date and informs them of the¡present knowledge of the molecular biology of selenium, its incorporation into proteins as selenocysteine, and the role that this element and selenium-containing proteins (selenoproteins) play in health and development. The current edition will be an important resource for scientists and investigators in the selenium field, students, and physicians who wish to learn more about this fascinating micronutrient
Inhalt:
Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date
Anmerkung:
Description based upon print version of record
,
Selenium; Dedication; Foreword; Preface; Acknowledgements; Contents; Contributors; Chapter 1: History of Selenium Research; 1.1 Previously Published Recollections of the History of Selenium Research; 1.2 Berzelius and the Discovery of Selenium; 1.3 Bibliometric Analysis of Selenium Research Since 1945; 1.3.1 The First Papers from the Selenium Research Field as Found in the ISI Web of Science Database; 1.3.2 Size and Development of the Selenium Research Field; 1.3.3 Subject Areas in Selenium Research
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1.3.4 The Most Cited Publications on "Selenium," "Selenoproteins," and "Selenocysteine" Until Present Day1.4 The Future of Selenium Research?; References; Part1: Selenocysteine Biosynthesis and Incorporation into Protein; Chapter 2: Selenocysteine Biosynthesis and the Replacement of Selenocysteine with Cysteine in the Pathway; 2.1 Introduction; 2.2 Sec Biosynthesis; 2.2.1 Background; 2.2.2 Seryl-tRNA Synthetase (SerRS); 2.2.3 Phosphoseryl-tRNA Kinase (PSTK); 2.2.4 Selenophosphate Synthetases (SPS1 and SPS2); 2.2.5 Selenophosphate Synthase (SecS); 2.3 De novo Biosynthesis of Cys
,
2.3.1 Cys/Sec Replacement in vitro2.3.2 Cys/Sec Replacement in NIH 3T3 Cells; 2.3.3 Cys/Sec Replacement in Mice; 2.4 Conclusions; References; Chapter 3: Molecular Mechanism of Eukaryotic Selenocysteine Incorporation; 3.1 Introduction; 3.2 The Core Factors; 3.2.1 SECIS Elements; 3.2.2 SECIS-Binding Protein 2; 3.2.3 Sec-Specific Elongation Factor; 3.3 Cis -Acting Elements Affecting Sec Incorporation; 3.3.1 Sequence Context Effects on Termination Efficiency; 3.3.2 Sequence Context Effects on Sec Incorporation; 3.3.3 Sequence Context Effects from a Distance
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3.3.4 Mechanism of Sec Incorporation in Transcripts with Multiple UGA Codons3.4 Putting It All Together: In Vitro Reconstitution; References; Chapter 4: SECIS-Binding Proteins Regulate the Expression of the Selenoproteome; 4.1 Introduction; 4.2 SBP2; 4.2.1 Expression of SBP2; 4.2.2 SECIS-Binding Activity of SBP2; 4.2.3 RNA-Binding Domain of SBP2; 4.2.4 SBP2 as an Essential Factor for Sec Incorporation; 4.2.5 SBP2 as the Master Regulator of Selenoprotein Synthesis; 4.2.6 Importance of the SBP2:SECIS Interaction in Human Disease; 4.3 Ribosomal Protein L30; 4.3.1 SECIS-Binding Activity of L30
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4.3.2 Role of L30 in Sec Incorporation4.4 eIF4a3; 4.4.1 SECIS-Binding Activity of eIF4a3; 4.4.2 eIF4a3 Is a Negative Regulator of Sec Incorporation; 4.4.3 eIF4a3 Is Regulated by Selenium; 4.4.4 Additional Roles for eIF4a3 in Regulating Selenoprotein Synthesis?; 4.5 Nucleolin; 4.5.1 SECIS-Binding Activity of Nucleolin; 4.5.2 Role of Nucleolin in Selenoprotein Synthesis; 4.6 Other SECIS-Binding Proteins; 4.7 Conclusions; References; Chapter 5: A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation; 5.1 Introduction; 5.2 Initial Binding
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5.3 Codon Recognition: Kinetic Proofreading and Induced Fit
Weitere Ausg.:
ISBN 9781461410249
Weitere Ausg.:
Buchausg. u.d.T. Selenium New York : Springer, 2012 ISBN 9781461410249
Weitere Ausg.:
ISBN 146141024X
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Sehen
;
Molekularbiologie
;
Sehen
;
Gesundheit
DOI:
10.1007/978-1-4614-1025-6
URL:
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