Format:
Online-Ressource (XI, 373p. 59 illus., 15 illus. in color, digital)
ISBN:
9781461423836
Series Statement:
Current Topics in Neurotoxicity 2
Content:
Michael Aschner
Content:
Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHg's accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This book will provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
Note:
Description based upon print version of record
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Methylmercury and Neurotoxicity; Preface; Contents; Contributors; Chapter 1: Epidemiological Update of Methylmercury and Minamata Disease; Introduction; Brief History of Minamata Disease; Early Studies on Exposure Evaluation and Health Effects; Congenital Minamata Disease and Effects of Fetal Exposure; Long-Term Exposure and Chronic Effects; Conclusions; References; Chapter 2: Epidemiological Evidence on Methylmercury Neurotoxicity; Introduction; Review Strategy; Developmental Neurotoxicity; Neurotoxicity in Adults; Uncertainties; Discussion; Conclusions; References
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Chapter 3: The Impact of Prenatal Exposure to Methylmercury and Maternal Nutritional Status on Child Development: Findings from the Seychelles Child Development StudyIntroduction; Seychelles Child Development Study; Setting; Assessment of Prenatal Exposure to MeHg; Cohorts and Test Batteries; Pilot Cohort; Main Cohort; Nutrition Cohort I; Nutrition Cohort II; Findings to Date; Pilot Cohort; Main Cohort; Nutrition Cohort I; Benchmark Dose Analysis; Background; Basic Principles; Benchmark Findings to Date; Methodological Considerations for Benchmark Modeling; Summary; References
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Chapter 4: Methylmercury and Fish Nutrients in Experimental ModelsAnimal Models; Markers of Exposure; Lactational Exposure; Nutrients in Fish; Selenium; DHA; Experimental Designs; Adult-Onset Exposure to Methylmercury and Nutrients; Methylmercury; Adult-Onset Methylmercury Exposure and Selenium; Adult-Onset Exposure and n -3 PUFAs; Developmental Exposure to Nutrients and Methylmercury; Behavioral Effects of Developmental Methylmercury Exposure; Developmental Methylmercury in Combination with Nutrients; Discrimination Reversals; Reinforcer Efficacy and Reward Processing
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Methylmercury and Neurotransmitter SystemsConcluding Remarks; References; Chapter 5: Mercury-Dependent Inhibition of Selenoenzymes and Mercury Toxicity; Introduction; Selenium in the Diet; Selenocysteine Biochemistry; Selenium as the Molecular Target of Mercury Toxicity; Fetotoxic Specificity of Mercury Toxicity; Conclusions; References; Chapter 6: Redox State in Mediating Methylmercury Neurotoxicity; Introduction; Redox State in the Biological Systems; The Glutathione System; Thioredoxins; Sulfhydryl Proteins; Selenols; Thiols as MeHg Targets: Neurotoxic Consequences; MeHg and the GSH System
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Sulfhydryl ProteinsSynaptic Proteins; Antioxidant Enzymes; Selenols as MeHg Targets: Neurotoxic Consequences; MeHg Interaction with Selenoproteins; MeHg Interaction with Low-Molecular-Weight Organoselenium Compounds; Conclusions; References; Chapter 7: The Role of Thyroid Modulation by Methylmercury in Developmental Neurotoxicity; Introduction; Thyroid Hormone Deficiency and Neurodevelopmental Defects; Key Molecules in the Thyroid Hormone Action; Thyroid Hormone Binding Proteins; Thyroid Hormone Transporters; Iodothyronine Deiodinases; Thyroid Hormone Receptors
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Possible Link Between MeHg Neurotoxicity and Impaired Thyroid Hormone Action
Additional Edition:
ISBN 9781461423829
Additional Edition:
Buchausg. u.d.T. ISBN 9781461423829
Language:
English
DOI:
10.1007/978-1-4614-2383-6
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