Umfang:
Online-Ressource (XVII, [8], 561 S.)
ISBN:
9781780643960
Serie:
CABI Books
Inhalt:
This book covers Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae across a range of host species. They are considered in regards to increasing drug resistance, HIV co-infection associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis.
Inhalt:
Intro -- Tuberculosis, Leprosy and Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria -- Copyright -- Contents -- Contributors -- Introduction - The Many Hosts of Mycobacteria: An Interdisciplinary Approach to Understanding Mycobacterial Diseases -- About the Cover -- 1: Introduction and Epidemiology of Mycobacterium tuberculosis Complex in Humans -- History of Tuberculosis -- Pathogenesis of TB and Routes of Infection -- Early Intervention in TB Management -- Susceptibility and Spread of TB Infection -- Epidemiology of TB -- Strategies of TB Control -- TB and HIV Co-infection -- Treatment of TB -- First-line Drugs -- Fixed-dose TB Tablets -- Second-line Drugs -- Acquisition of Drug Resistance -- Hope of New TB Agents -- Worldwide Prevalence of Drug Resistance -- References -- 2: Comparative Mycobacteriology of the Mycobacterium tuberculosis Complex -- Introduction -- The M. tuberculosis Complex (MTBC) -- MTBC Genomics -- Host Preference -- Animal-adapted Strains -- Pathoadaptation and Virulence Factors -- RD1 -- MPT70 and MPT83 -- Lipids -- Conclusions -- Acknowledgements -- References -- 3: Immunopathogenesis of Tuberculosis in Humans -- Global Burden of Tuberculosis -- Pathogenesis of Human Tuberculosis -- Clinical presentation and diagnosis -- Granulomas -- Inflammation and cell death -- In situ studies of human tuberculosis -- Human Immunity to Tuberculosis -- Innate Immune Responses to Tuberculosis -- Macrophages -- Recognition and uptake of bacteria -- Macrophage effector functions -- Vitamin D modulates human macrophage effector functions -- Dendritic Cells -- Neutrophils -- Natural Killer Cells -- Human Immunogenetics and TuberculosisSusceptibility -- Adaptive Immune Response to Tuberculosis -- Unconventional T cells in Mtb Infection -- ᵞᵟ T cells -- CD1-restricted T cells.
Anmerkung:
Description based upon print version of record
,
The Many Hosts of Mycobacteria -- Copyright -- Contents -- Contributors -- Introduction - The Many Hosts of Mycobacteria: An Interdisciplinary Approach to Understanding Mycobacterial Diseases -- About the Cover -- 1: Introduction and Epidemiology of Mycobacterium tuberculosis Complex in Humans -- History of Tuberculosis -- Pathogenesis of TB and Routes of Infection -- Early Intervention in TB Management -- Susceptibility and Spread of TB Infection -- Epidemiology of TB -- Strategies of TB Control -- TB and HIV Co-infection
,
Comparative Mycobacteriology of the Mycobacterium tuberculosis Complex -- Introduction -- The M. tuberculosis Complex (MTBC) -- MTBC Genomics -- Host Preference -- Animal-adapted Strains -- Pathoadaptation and Virulence Factors -- RD1 -- MPT70 and MPT83 -- Lipids -- Conclusions -- Acknowledgements -- References -- 3: Immunopathogenesis of Tuberculosis in Humans -- Global Burden of Tuberculosis
,
Pathogenesis of Human Tuberculosis -- Clinical presentation and diagnosis -- Granulomas -- Inflammation and cell death -- In situ studies of human tuberculosis -- Human Immunity to Tuberculosis -- Innate Immune Responses to Tuberculosis -- Macrophages -- Recognition and uptake of bacteria -- Macrophage effector functions -- Vitamin D modulates human macrophage effector functions -- Dendritic Cells -- Neutrophils -- Natural Killer Cells -- Human Immunogenetics and TuberculosisSusceptibility -- Adaptive Immune Response to Tuberculosis -- Unconventional T cells in Mtb Infection -- ᵞᵟ T cells
,
CD4 and CD8 T Cells -- CD4 T cells -- Regulatory T cells (Treg) -- CD8 T cells -- The Humoral Immune Response to Mtb: B Cells and Antibodies -- B cells -- Antibodies -- TB and Co-morbidities -- TB and HIV -- Helminths and TB -- Diabetes and TB -- TB Vaccines -- References -- 4: Current Methods for Diagnosis of Human Tuberculosis and Considerations for Global Surveillance -- Introduction -- Direct Detection of Mycobacterium tuberculosis -- Sputum smear microscopy -- Culture
,
Conventional culture -- Microscopic observation of mycobacterial growth -- Automated culture systems -- Detection of Immune Response Markers for the Diagnosis of TB -- Tuberculin skin test -- Biomarker-based assays -- Antibody-detection assays -- Interferon-ᵞ release assays -- Detection of Pathogen Markers for the Diagnosis of TB -- Antigen biomarker-based assays -- Nucleic acid-based tests -- Detection of single target by cycling amplification (i.e. polymerase chain reaction (PCR)) -- Detection by isothermal and other amplification methodologies
,
Simultaneous detection of multiple targets by Multiplex PCR, microarray and other technologies
Weitere Ausg.:
ISBN 9781780643977
Weitere Ausg.:
ISBN 9781780643960
Weitere Ausg.:
Druckausg. Tuberculosis, leprosy and other mycobacterial diseases of man and animals
Weitere Ausg.:
Print version Mukundan, H Tuberculosis, Leprosy and Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria Wallingford : CABI,c2015
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Mykobakteriose
;
Tuberkulose
;
Electronic books
DOI:
10.1079/9781780643960.0000
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