Kooperativer Bibliotheksverbund

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Format: 1 online resource (1727 pages) : , illustrations

Edition: Seventh edition.

ISBN: 1-9751-4265-9

Content: Evidence-based, superbly illustrated, and easy to read, Berek & Hacker's Gynecologic Oncology, Seventh Edition, remains your reference of choice for authoritative information on every aspect of gynecologic malignancies. Templated chapters provide quick access to guidance on everything from general principles through diagnosis and medical and surgical management. This fully revised edition offers the practical, state-of-the-art coverage you need when caring for women with preinvasive disease; ovarian, breast, uterine, cervical, vulvar, and vaginal cancers; and gestational trophoblastic disease. All chapters have been carefully updated to reflect the most current literature and practice recommendations. Presents summaries on signs and symptoms, staging, treatment, relevant basic science, genetics, and molecular issues. Key topics include preoperative care, laparoscopy, robotics, nutritional therapy, cancer in pregnancy, surgical techniques, symptom relief, and palliative care. Includes new chapters on genetics; cancer cell biology; and biologic, targeted, and immune therapies, as well as completely rewritten chapters on chemotherapy and communication skills. Features a new, visually appealing two-column design similar to Berek & Novak's Gynecology, 16th Edition. Helps you visualize key concepts with full-color illustrations and drawings, pathology slides, and clinically relevant diagrams. Presents the knowledge and expertise of global leaders in gynecologic oncology, keeping you at the forefront of your field and preparing you for board exams. Clearly translates basic science to clinical practice, making it an excellent everyday resource for gynecologic oncologists and fellows, general gynecologists, and medical and radiation oncologists. Enrich Your eBook Reading ExperienceRead directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Note: Includes index. , section I. General principles -- section II. Disease sites -- section III. Medical and surgical topics -- section IV. Quality of life.

Additional Edition: ISBN 1-9751-4264-0

Language: English

UID:

Format: 1 online resource (1727 pages)

Edition: 7th ed.

ISBN: 9781975142650

Note: Cover -- Title Page -- Copyright -- Dedication -- Contributors -- Foreword to the First Edition -- Preface -- Contents -- Section I: General Principles -- Chapter 1: Cancer Genetics -- Historic Perspective -- Genetic Changes -- Sporadic -- Hereditary -- Oncogenes -- Types of Oncogenes -- Tumor Suppressor Genes (Anti-Oncogenes) -- Epigenetic Changes -- Genetic Changes in Gynecologic Malignancies -- Endometrial Cancer -- Uterine Mesenchymal Tumors -- Ovarian Cancer -- Ovarian Sex Cord Stromal Tumors -- Cervical Cancer -- Vulvar Cancer -- Gestational Trophoblastic Disease -- Chapter 2: Cancer Cell Biology -- Cell Growth and Proliferation -- Oncogenes -- Tumor Suppressor Genes -- DNA Repair -- DNA Damage Response Defects and Synthetic Lethality to Enhance Efficacy of Cancer Therapy -- Cell Death Pathways -- Autophagy -- Apoptosis -- Necrosis -- Cancer Stem Cells -- Cellular Senescence -- Cell Metabolism -- Hormone Metabolism -- Post-translational Modifications -- Cell Invasion and Metastasis -- Epithelial-to-Mesenchymal Transition -- Tumor Microenvironment -- Immune Checkpoints -- Angiogenesis -- Biomarkers -- Tumor Markers -- Chapter 3: Biologic, Targeted, and Immune Therapy -- Inhibitors of Growth Factor Receptors -- EGFR Inhibitors -- EGFR Inhibitors-Small Molecules -- EGFR Inhibitors-Monoclonal Antibodies -- Her2/Neu Inhibitors -- Her2/Neu Inhibitors-Small Molecules -- Her2/Neu Inhibitors-Monoclonal Antibodies -- PDGFR Inhibitors-Monoclonal Antibodies -- Inhibitors of Angiogenesis -- VEGFR Inhibitors-Small Molecules -- VEGFR Inhibitors-Monoclonal Antibodies -- Inhibitors of Other Intracellular Kinases -- Small Molecules -- Braf (Rapidly Activated Fibrosarcoma) Inhibitors -- MEK1-2 (MAPK/ERK Kinase) Inhibitors -- CDK 4-6 (Cyclin-Dependent Kinases 4-6) Inhibitors -- ALK (Anaplastic Lymphoma Kinase) Inhibitors. , PI-3K (Phosphatidylinositol 3-Kinase) Inhibitors -- mTOR (Mammalian Target of Rapamycin) Inhibitors -- Inhibitors of DNA Repair -- PARP (Poly-ADP Ribose-Polymerase) Inhibitors -- Immunotherapy -- Cytokines -- Monoclonal Antibodies -- Immune Checkpoint Inhibitors -- Anti-PD-1 (Programmed Cell Death Receptor-1) Antibodies -- Anti-PD-L1 (Programmed Cell Death Receptor Ligand-1) Antibodies -- Therapeutic Cancer Vaccines -- Cell-Based Vaccines -- Glycan-Based Vaccines -- Adoptive Cell Therapy -- Chapter 4: Chemotherapy -- General Principles -- Tumor Growth and Chemotherapy -- Differential Sensitivity -- Therapeutic Index -- Brief History of Chemotherapy -- Biologic Factors Influencing Treatment -- Cell Kinetic Concepts -- Cancer Cell Growth -- Principles of Chemotherapy -- Neoadjuvant Chemotherapy -- Hyperthermic Intraperitoneal Chemotherapy -- Antibody-Drug Conjugates -- Chemotherapy in Pregnancy -- Drug Resistance -- Excretion -- Drug Interactions -- Combination Chemotherapy -- Clinical Benefit -- RECIST Criteria -- Dose Adjustment -- Carboplatin Dose Calculation -- Toxicities and Their Management -- Antineoplastic Drugs -- Alkylating Agents -- Antitumor Antibiotics and Topoisomerase Inhibitors -- Antimetabolites -- Plant Alkaloids (Mitotic Spindle Agents) -- Chapter 5: Radiation Therapy -- Radiation Biology -- Radiation Damage and Repair -- Cell Survival Curves -- Fractionation -- Dose-Rate Effect -- The Four Rs -- Treatment Strategies for Overcoming Radioresistance of Hypoxic Cells -- Linear-Energy Transfer and Relative Biologic Effectiveness -- Hyperthermia -- Interactions between Radiation and Drugs -- Radiation Therapy and the Immune System -- Therapeutic Ratio -- Effects of Radiation on Normal Tissues -- Scoring of Late Complications of Radiation Therapy. , Treatment Strategies to Exploit Differences Between Tumor and Normal Tissue in the Response to Fractionated Radiation Therapy -- Combinations of Surgery and Radiation Therapy -- Physical Principles -- Ionizing Radiations Used in Therapy -- Interactions of Radiation With Matter -- Measurement of Absorbed Dose -- Inverse Square Law -- Radiation Techniques -- External Beam Irradiation -- Brachytherapy -- Palliation -- Chapter 6: Pathology -- Cervix -- Squamous Lesions of the Cervix -- Human Papilloma Virus -- Cervicovaginal Cytology-Pap Testing -- Glandular Lesions of the Cervix -- Mesenchymal Tumors -- Vagina -- Squamous Lesions of the Vagina -- Glandular Lesions of the Vagina -- Fibroepithelial Stromal Polyp -- Sarcoma Botryoides -- Melanoma -- Postoperative Spindle Cell Nodule -- Vulva -- Squamous Cell Lesions of the Vulva -- Other Vulvar Lesions -- Mesenchymal Tumors -- Aggressive Angiomyxoma -- Melanocytic Tumors -- Uncommon Neoplasms -- Uterine Corpus -- Endometrial Neoplasms -- Endometrial Carcinoma -- Histologic Types -- Histologic Grading of Endometrioid Carcinoma -- Pathologic Staging of Endometrial Carcinoma -- Mesenchymal Neoplasms -- Uterine Tumor Resembling Ovarian Sex Cord-Stromal Tumor -- Endometrial Stromal Tumors -- Undifferentiated Uterine Sarcoma -- Other Uterine Mesenchymal Tumors -- Mixed Müllerian Neoplasms -- Adenofibroma -- Atypical Polypoid Adenomyoma -- Adenosarcoma -- Carcinosarcoma -- Ovary -- Ovarian Epithelial Tumors -- Sex Cord-Stromal Tumors -- Germ Cell Tumors -- Embryonal Carcinoma -- Miscellaneous Ovarian Tumors -- Secondary Tumors of the Ovary-Metastases -- Nonneoplastic Lesions of the Ovary -- Luteinized Ovarian Conditions -- Fallopian Tube -- Primary Tubal Carcinoma -- Adenomatoid Tumor -- Gestational Trophoblastic Disease -- Hydatidiform Mole -- Choriocarcinoma -- Placental Site Trophoblastic Tumor. , Chapter 7: Epidemiology and Biostatistics -- Descriptive Statistics -- Incidence -- Prevalence -- Cancer Survival -- Etiologic Studies -- Case-Control Study -- Cohort Studies -- Statistical Inference and Validity -- Statistical Inference -- Statistical Distributions and Tests -- Validity -- Other Criteria for Judging an Epidemiologic Study -- Cancer Risk and Prevention -- Cervical Cancer -- Endometrial Cancer -- Ovarian Cancer -- Other Gynecologic Neoplasms -- Cancer Prevention -- Secondary Prevention -- Test Definitions -- Sensitivity -- Specificity -- Predictive Value -- Screening Strategies -- Section II: Disease Sites -- Chapter 8: Preinvasive Disease -- Cervix -- Classification of Preinvasive Cervical Disease -- Understanding the Cervical Transformation Zone -- IFCPC Colposcopic Terminology of the Cervix, Vagina, and Vulva -- Systematic Approach to Colposcopy -- Indications for Colposcopy -- Human Papillomaviruses and Cervical Neoplasia -- Human Papillomavirus Vaccines -- The WHO Initiative for the Elimination of Cervical Cancer as a Public Health Problem -- Screening for Cervical Neoplasia -- Treatment of Cervical Intraepithelial Neoplasia -- Treatment Modalities -- Vagina -- Classification of Vaginal Intraepithelial Neoplasia -- Clinical Profile -- Diagnosis -- Treatment of High-Grade Vaginal Intraepithelial Neoplasia -- Vulva and Perianal Area -- Classification -- Paget Disease -- Clinical Profile of High-Grade Vulvar Intraepithelial Neoplasia (uVIN) -- Diagnosis -- Natural History of High-Grade Vulvar Intraepithelial Neoplasia -- Differentiated Vulvar Intraepithelial Neoplasia (dVIN) -- Treatment of High-Grade Vulvar Intraepithelial Neoplasia -- HPV Vaccination -- Multicentric Lower Genital Tract Neoplasia -- Chapter 9: Cervical Cancer -- Diagnosis -- Symptoms -- Signs -- Biopsy -- Colposcopy for Invasive Cancer -- Staging. , Noninvasive Diagnostic Studies -- Surgical Staging -- Patterns of Spread -- Direct Infiltration -- Lymphatic Spread -- Hematogenous Spread -- Treatment -- Microinvasive Carcinoma -- 2018 FIGO Stages IB1, IB2, and Early-Stage IIA1 Cervical Cancer -- Stage IB3 Cervical Carcinoma -- Prognostic Factors for Stages IB to IIA -- Stages IIB to IVA Disease -- Nonsquamous Histologic Types -- Adenocarcinoma -- Adenosquamous Carcinoma -- Glassy Cell Carcinoma -- Adenoma Malignum (Minimum Deviation Adenocarcinoma) -- Adenoid Cystic Carcinoma -- Adenoid Basal Carcinoma -- Clear Cell Adenocarcinoma -- Villoglandular Papillary Adenocarcinoma -- Small-Cell, including Small-Cell Neuroendocrine Carcinoma -- Large-Cell Neuroendocrine Carcinoma -- Serous Carcinoma -- Sarcoma -- Lymphoma -- Verrucous Carcinoma -- Melanoma -- Metastatic Carcinoma -- Cancer of the Cervical Stump -- Invasive Cancer Found after Simple Hysterectomy -- Coexistent Pelvic Mass -- Cervical Bleeding -- Recurrent Cervical Cancer -- Radical Hysterectomy for Recurrence -- Chemotherapy -- Chapter 10: Uterine Cancer -- Prevention of Disease and Screening of Asymptomatic Women -- Clinical Features -- Symptoms -- Signs -- Diagnosis -- Preoperative Investigations -- Staging -- Spread Patterns -- Prognostic Variables -- Age -- Histologic Type -- Histologic Grade and Myometrial Invasion -- Vascular Space Invasion -- Results of Peritoneal Cytology -- Hormone Receptor Status -- Nuclear Grade -- Tumor Size -- DNA Ploidy and Other Biologic Markers -- Body Mass Index -- Method of Treatment -- Endometrial Hyperplasia -- Diagnosis -- Treatment -- Treatment of Endometrial Cancer -- Stage I and Stage II Occult -- Clinical Stage II -- Surgical Stage IIIA -- Surgical Stage IIIB -- Surgical Stage IVA -- Surgical Stage IVB -- Special Clinical Circumstances -- Recurrent Endometrial Cancer -- Isolated Vaginal Recurrence. , Nodal Recurrence.

Additional Edition: Print version: Berek, Jonathan Berek and Hacker's Gynecologic Oncology Philadelphia : Wolters Kluwer Health,c2020 ISBN 9781975142643

Language: English

Keywords: Electronic books.

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