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Format: 1 Online-Ressource (X, 287 Seiten) , Illustrationen, Diagramme

ISBN: 9783030111144

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-11113-7

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-11115-1

Language: English

Subjects: Medicine

Keywords: Medizin ; Mikrobiologie ; Infektionskrankheit ; Aufsatzsammlung ; Electronic books. ; Index not Present.

DOI: 10.1007/978-3-030-11114-4

URL: Volltext  (kostenfrei)

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URL: SpringerLink

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Author information: Pluschke, Gerd

UID:

Format: X, 287 p. 34 illus., 30 illus. in color. , online resource.

ISBN: 9783030111144

Content: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.

Note: Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- Buruli Ulcer in Australia -- Mycobacterium Ulcerans Infection in French Guiana; Current State of Knowledge -- Buruli Ulcer in Japan -- Population Genomics and Molecular Epidemiology of Mycobacterium Ulcerans -- Mycolactone: More Than Just a Cytotoxin -- The Immunology of Buruli Ulcer -- Buruli Ulcer in Animals and Experimental Infection Models -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- Antimicrobial Treatment of Mycobacterium Ulcerans Infection -- Thermotherapy of Buruli Ulcer -- Secondary Infection of Buruli Ulcer Lesions -- Management of BU-HIV Co-infection -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- Transdisciplinary Research and Action to Stop Buruli Ulcer– A Case Study from Philanthropy.

In: Springer eBooks

Additional Edition: Printed edition: ISBN 9783030111137

Additional Edition: Printed edition: ISBN 9783030111151

Language: English

DOI: 10.1007/978-3-030-11114-4

URL: https://doi.org/10.1007/978-3-030-11114-4

UID:

Format: 1 online resource (290 pages)

Edition: 1st ed.

ISBN: 9783030111144

Note: Intro -- Preface -- Contents -- Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- 1 Introduction -- 2 Management of BU in Africa -- 2.1 Structure of Health Systems in Africa and Implications for the Management of BU -- 2.2 Diagnosis and Treatment of BU -- 3 Geographical Distribution of BU: Reporting of Cases Versus Actual Situation in Africa -- 4 Distribution of BU Among Affected Populations in Africa -- 5 The Etiology of BU in Africa -- 6 Future Perspectives -- References -- Buruli Ulcer in Australia -- 1 Bairnsdale Ulcer and the Discovery of Mycobacterium ulcerans -- 2 Buruli Ulcer in Queensland -- 3 Buruli Ulcer in Victoria -- 4 Buruli Ulcer in Animals in Victoria -- 5 Recent Epidemiology of Buruli Ulcer in Victoria -- 6 Clinical Management of Buruli Ulcer in Australia -- 7 Buruli Ulcer: The Australian Paradox -- References -- Mycobacterium ulcerans Infection in French Guiana -- Current State of Knowledge -- 1 Introduction -- 2 Links Between the Human Host and the Bacteria -- 2.1 Risk Factors of BU in French Guiana -- 2.2 Epidemiology and Clinical Aspects of BU in French Guiana -- 2.3 A Link Between Rainfall and BU Cases -- 2.4 Genetic Diversity of M. ulcerans Among Local BU Cases -- 3 Environment and the Bacteria -- 3.1 First Detection of Mycobacterium ulcerans DNA in Environmental Samples from French Guiana -- 3.2 Biodiversity Drivers of M. ulcerans Distribution Across Freshwater Habitats -- 4 Conclusion -- References -- Buruli Ulcer in Japan -- 1 Epidemiology and Bacteriological and Genomic Features of M. ulcerans subsp. shinshuense -- 1.1 Epidemiology -- 1.2 Genome -- 1.3 Biochemical Properties -- 2 Clinical Features and Treatment of BU in Japan -- 2.1 Antimicrobial Treatment -- 2.2 Alternative Treatments of BU -- 2.3 Other Suggested Therapies. , 3 M. ulcerans subsp. shinshuense in the Environment of Japan -- 3.1 Detection of Environmental M. ulcerans subsp. shinshuense in Japan -- 3.2 Seasonal Variation of BU in Japan -- 3.3 PCR Detection of M. ulcerans subsp. shinshuense DNA in the Environment -- 4 BU in Asia and Future Perspectives -- 4.1 BU in China -- 4.2 Toward Detection of BU in Other Asian Countries -- References -- Population Genomics and Molecular Epidemiology of Mycobacterium ulcerans -- 1 First Insights from the Complete Genome of Mycobacterium ulcerans -- 2 An Aquatic Origin and Two Bottlenecks for a Recently Emerged, and Globally Distributed Pathogen -- 3 New Understandings from Genomics on the Spread of M. ulcerans Across Africa -- 4 Genomic Approaches to Micro-Molecular Epidemiological Investigations of BU -- 5 Distinguishing Relapse from Reinfection and Familial Studies -- 6 Summary and Future Perspectives -- References -- Mycolactone: More than Just a Cytotoxin -- 1 Mycolactone and BU Disease -- 1.1 Pharmacodistribution -- 1.2 Mycolactone Contribution to BU Disease Manifestations -- 1.2.1 Pathogenesis and Histopathology of BU Lesions -- 1.2.2 Local Analgesia -- 1.2.3 Local and Systemic Immunomodulation -- 2 Molecular Targets and Mechanisms of Action -- 2.1 Sec61 Blockade -- 2.2 AT2R Stimulation -- 2.3 N-WASP Activation -- 3 Conclusions -- References -- The Immunology of Buruli Ulcer -- 1 Buruli Ulcer: The First Histological Observations of a Necrotic Track -- 2 Host Attempts to Control Mycobacterium ulcerans Infection -- 2.1 Local Immune Response -- 2.2 Regional and Systemic Responses -- 3 Diagnostics Research Make it Evident: The Triggering of Cellular and Humoral Arms -- 4 Antibiotic Treatment in the Aid of the Host Immune Response -- 5 Epidemiological Clues and the Search for Novel Resistance and Susceptibility Markers. , 6 (Un)successful Preventive Approaches -- 7 Novel Models for Investigation and Future Perspectives -- 8 Conclusions -- References -- Buruli Ulcer in Animals and Experimental Infection Models -- 1 Naturally Infected Animals -- 2 The Mouse (Mus musculus) Model -- 2.1 History of the BU Mouse Model -- 2.2 Experimental Infection of the Mouse -- 2.2.1 Infection Sites -- 2.2.2 Mouse Strains -- 2.2.3 Mycobacterial Strains Used for Experimental Infection -- 2.2.4 Dose and Preparation of the Bacterial Inocula -- 2.2.5 Infection Outcomes and What to Measure -- 2.3 Research Applications for the Mouse Model -- 2.3.1 Antimicrobial Compound Testing -- 2.3.2 Vaccine Development -- 2.3.3 Study of the Pathogenesis of Buruli Ulcer and the Immune Response to the Disease -- 3 Other Animal Models -- 3.1 Guinea Pig (Cavia porcellus) -- 3.2 Pig (Sus scrofa) -- 3.3 Grasscutter (Thryonomys swinderianus) -- 3.4 Anole Lizard (Anolis carolinensis) -- 3.5 Nine-Banded Armadillo (Dasypus novemcinctus) -- 3.6 Cynomologus Monkey (Maca fascicularis) -- 3.7 African Rat (Mastomys natalensis) -- 3.8 Common Brushtail Possum (Trichosurus vulpecula) -- 4 Conclusions -- References -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- 1 Introduction -- 2 Currently Available Laboratory Diagnostic Tests -- 2.1 Specimen Collection and Reference Standards -- 2.2 IS2404 PCR: The Current Gold Standard -- 2.3 Detection of AFBs by Microscopy: A Test for the Primary Healthcare Level with Limited Sensitivity -- 2.4 Considerations on the Accuracy of IS2404 qPCR and AFB Detection by Microscopy: Direct Comparison of the Two Techniques -- 2.5 Histopathology and Cultivation of M. ulcerans: Research Tools Rather than Diagnostic Tests -- 2.6 From Theory into Practice: Diagnosis of BU in Resource-Constrained Endemic Countries. , 3 Development of BU Diagnostics for District Hospital or Primary Healthcare Facility Level -- 3.1 LAMP: An Alternative for the Detection of M. ulcerans DNA -- 3.2 Detection of Mycolactone by f-TLC: Struggling with the Complexity of Lipid Extracts -- 3.3 Serological Tests: Only Suitable for Seroepidemiological Studies -- 3.4 Detection of Mycolactone and M. ulcerans Proteins by Antigen Detection Assays: Prospects for the Development of an RDT -- 4 Discussion -- 5 Outlook -- References -- Antimicrobial Treatment of Mycobacterium ulcerans Infection -- 1 Historical Aspects -- 2 Antimicrobial Susceptibility of M. ulcerans -- 2.1 Ansamycins/Rifamycins -- 2.2 Aminoglycosides: Streptomycin -- 2.3 Amikacin -- 2.4 Macrolides: Clarithromycin -- 2.5 Azithromycin -- 2.6 Fluoroquinolones -- 2.7 Clofazimine -- 2.8 Dapsone -- 2.9 Doxycycline -- 2.10 Oxazolidinones -- 2.11 Avermectins -- 2.12 Trimethoprim and Epiroprim -- 3 Experimental Drugs -- 4 Clinical Studies -- 4.1 Secondary Infection -- 4.2 HIV Co-infection -- 5 Conclusions -- Areas of Uncertainty -- and Future Directions -- References -- Thermotherapy of Buruli Ulcer -- References -- Secondary Infection of Buruli Ulcer Lesions -- 1 Background -- 2 Bacterial Species Associated with Secondary Infections -- 2.1 Species Diversity -- 3 Bacterial Burden -- 4 Diagnosing Secondary Infection in BU -- 5 Drug Susceptibility Patterns of Bacterial Isolates from BU Lesions -- 6 Molecular Epidemiology -- 6.1 Sources of Infection -- 7 Predisposing Socio-Economic Factors -- 8 Prevention of Secondary Infection -- 9 Wound Care -- References -- Management of BU-HIV Co-infection -- 1 Epidemiology -- 2 Clinical Effects of BU-HIV Co-Infection -- 3 Diagnosis -- 4 Management of BU-HIV Co-Infection -- 4.1 BU Treatment -- 4.2 HIV Treatment -- 4.3 HIV and BU Treatment Interactions. , 4.4 Children -- 4.5 Tuberculosis -- 4.6 Service Provision -- References -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- 1 Introduction -- 2 Part One -- 2.1 Predisposing Factors: Cultural Perceptions of BU Causality, Social Stigma, and Preference for Traditional Healing -- 2.1.1 Cultural Perceptions of BU Causality -- Benin -- Cameroon -- Ghana -- 2.1.2 Stigma and Social Risk -- 2.1.3 Traditional Healers -- Enabling Factors -- 2.2 Service Level Factors Affecting Health Care Seeking and Treatment Adherence -- 3 Part Two: Social Science Inspired Interventions -- 3.1 Outreach Education -- 3.2 Introducing Decentralized BU Care in Ouinhi, Benin -- 3.3 Establishing a BU Community of Practice: Cameroon -- 3.4 Yaws Cases Identified as a Result of BU Outreach in Cameroon: A Case for Integrated Skin Neglected Tropical Disease (NTD) Programs -- 3.5 BU Children's Support Group Ghana -- 3.6 Mhealth as a Tool in Monitoring BU Healing in Ghana -- 3.7 Transforming a BU Hospital into a Therapeutic Community for Inpatients -- 4 Conclusion -- References -- Transdisciplinary Research and Action to Stop Buruli Ulcer: A case Study from Philanthropy -- 1 Introduction -- 2 The Beginnings: Six Reasons Why -- 2.1 Reason #1: Lack of Funding Incentives -- 2.2 Reason #2: A Disease of Social Justice -- 2.3 Reason #3: A Disease with Devastating Consequences -- 2.4 Reason #4: The Pioneer Effect -- 2.5 Reason #5: Existing Critical Mass of Researchers and Implementing Agencies -- 2.6 Reason #6: Scalability and Uptake -- 2.7 Stop Buruli Initiative -- 3 The Model: Transdisciplinary Research and Implementation -- 4 Key Elements for Advancing Transdisciplinarity -- 4.1 Transdisciplinarity Does Not 'Just Happen' -- 4.2 Governance Model -- 5 Results -- 5.1 Diagnosis -- 5.2 Treatment -- 5.3 Transmission. , 5.4 Socio-Cultural Aspects.

Additional Edition: Print version: Pluschke, Gerd Buruli Ulcer Cham : Springer International Publishing AG,c2019 ISBN 9783030111137

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (X, 287 p. 34 illus., 30 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-11114-8

Content: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.

Note: Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- Buruli Ulcer in Australia -- Mycobacterium Ulcerans Infection in French Guiana; Current State of Knowledge -- Buruli Ulcer in Japan -- Population Genomics and Molecular Epidemiology of Mycobacterium Ulcerans -- Mycolactone: More Than Just a Cytotoxin -- The Immunology of Buruli Ulcer -- Buruli Ulcer in Animals and Experimental Infection Models -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- Antimicrobial Treatment of Mycobacterium Ulcerans Infection -- Thermotherapy of Buruli Ulcer -- Secondary Infection of Buruli Ulcer Lesions -- Management of BU-HIV Co-infection -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- Transdisciplinary Research and Action to Stop Buruli Ulcer– A Case Study from Philanthropy. , English

Additional Edition: ISBN 3-030-11113-X

Language: English

DOI: 10.1007/978-3-030-11114-4

UID:

Format: 1 online resource (X, 287 p. 34 illus., 30 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-11114-8

Content: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.

Note: Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- Buruli Ulcer in Australia -- Mycobacterium Ulcerans Infection in French Guiana; Current State of Knowledge -- Buruli Ulcer in Japan -- Population Genomics and Molecular Epidemiology of Mycobacterium Ulcerans -- Mycolactone: More Than Just a Cytotoxin -- The Immunology of Buruli Ulcer -- Buruli Ulcer in Animals and Experimental Infection Models -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- Antimicrobial Treatment of Mycobacterium Ulcerans Infection -- Thermotherapy of Buruli Ulcer -- Secondary Infection of Buruli Ulcer Lesions -- Management of BU-HIV Co-infection -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- Transdisciplinary Research and Action to Stop Buruli Ulcer– A Case Study from Philanthropy. , English

Additional Edition: ISBN 3-030-11113-X

Language: English

DOI: 10.1007/978-3-030-11114-4

UID:

Format: 1 online resource (X, 287 p. 34 illus., 30 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-11114-8

Content: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.

Note: Buruli Ulcer: History and Disease Burden -- Buruli Ulcer in Africa -- Buruli Ulcer in Australia -- Mycobacterium Ulcerans Infection in French Guiana; Current State of Knowledge -- Buruli Ulcer in Japan -- Population Genomics and Molecular Epidemiology of Mycobacterium Ulcerans -- Mycolactone: More Than Just a Cytotoxin -- The Immunology of Buruli Ulcer -- Buruli Ulcer in Animals and Experimental Infection Models -- Laboratory Diagnosis of Buruli Ulcer: Challenges and Future Perspectives -- Antimicrobial Treatment of Mycobacterium Ulcerans Infection -- Thermotherapy of Buruli Ulcer -- Secondary Infection of Buruli Ulcer Lesions -- Management of BU-HIV Co-infection -- Social Science Contributions to BU Focused Health Service Research in West-Africa -- Transdisciplinary Research and Action to Stop Buruli Ulcer– A Case Study from Philanthropy. , English

Additional Edition: ISBN 3-030-11113-X

Language: English

DOI: 10.1007/978-3-030-11114-4