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Format: 1 online resource (239 pages)

Edition: 1st ed.

ISBN: 9783030138646

Note: Intro -- Contents -- Introduction -- 1: Historical Terminology, Classifications, and Present Definition of DCM -- 1.1 Dilated Cardiomyopathies: The Classification Pathway -- 1.2 Genetic Dilated Cardiomyopathy and Etiological Classification -- 1.3 Future Perspectives -- References -- 2: Epidemiology -- 2.1 Towards Contemporary Clinical Epidemiology in Dilated Cardiomyopathy -- 2.2 Genetics and Future Perspectives -- References -- 3: Pathophysiology -- 3.1 Ventricular Remodeling in DCM -- 3.2 Genetic Pathophysiology and New Possible Proteins Involved in DCM [2] -- 3.3 Molecular Mechanisms of Cardiac Remodeling in HF [15] -- References -- 4: Etiological Definition and Diagnostic Work-Up -- 4.1 Clinical Presentation -- 4.2 Etiological Classification: A Critical Issue in Clinical Management of DCM -- 4.2.1 Need of Reclassification of the Disease During Follow-Up -- 4.3 Exclusion of Reversible Causes of Left Ventricular Dysfunction/Dilation -- 4.4 Diagnostic Work-Up in New-Onset LV Dysfunction/Dilation: A "Red Flags" Approach -- 4.4.1 Personal and Family History -- 4.4.2 Symptoms and Physical Examination -- 4.4.3 12 Lead Electrocardiogram -- 4.4.4 Laboratory Tests -- 4.4.4.1 Genetic Testing -- 4.4.5 Echocardiography -- 4.4.6 Cardiovascular Magnetic Resonance -- 4.4.7 Cardiac Catheterizations and Procedures -- 4.4.7.1 Coronary Angiogram -- 4.4.7.2 Cardiac Catheterization -- 4.4.7.3 Endomyocardial Biopsy -- 4.5 Conclusions -- References -- 5: Genetics of Dilated Cardiomyopathy: Current Knowledge and Future Perspectives -- 5.1 DCM-Associated Genes -- 5.1.1 Titin -- 5.1.2 Lamin A/C -- 5.1.3 Structural Cytoskeleton Z-Disk Genes -- 5.1.4 Desmosomal Genes -- 5.1.5 Sarcomeric (Motor) Genes -- 5.1.6 Ion Channel-Related Genes -- 5.1.7 Other Genes -- 5.2 Technical Issues in Genetic Sequencing. , 5.3 The Complexity in Variant Classification Process -- 5.4 The External Modulation of Genotype: Environmental Triggers -- 5.5 Evidence-Based Genotype-Phenotype Correlations -- 5.5.1 Lamin A/C -- 5.5.2 Titin -- 5.5.3 Filamin C -- 5.5.4 Insights from Clinical Presentation and Left Ventricular Reverse Remodeling (LVRR) -- References -- 6: Clinical Presentation, Spectrum of Disease, and Natural History -- 6.1 Spectrum of Disease -- 6.2 Clinical Presentation -- 6.3 Natural History -- References -- 7: Role of Cardiac Imaging: Echocardiography -- 7.1 Echocardiographic Features of Dilated Cardiomyopathy -- 7.2 Role of New Echocardiographic Techniques -- 7.3 Clinical Echocardiography in DCM: Advantages and Limitations in Clinical Practice -- 7.4 Prognostic Role of Echocardiographic Data in DCM -- References -- 8: Role of Cardiac Imaging: Cardiac Magnetic Resonance and Cardiac Computed Tomography -- 8.1 Cardiac Magnetic Resonance -- 8.2 Diagnostic Accuracy -- 8.3 Differential Diagnosis -- 8.4 Myocarditis Presenting as Left Ventricular Dysfunction -- 8.5 Other Secondary Forms of DCM -- 8.6 Prognostic Stratification -- 8.7 Macroscopic vs. Diffuse Fibrosis -- 8.8 Strain Analysis -- 8.9 Other Prognostic Indicators -- 8.10 Computed Tomography -- References -- 9: Endomyocardial Biopsy -- 9.1 Introduction -- 9.2 Technique -- 9.3 Complications -- 9.4 Indications in DCM Scenarios -- 9.5 Diagnosis of Myocarditis -- 9.6 Examples of Endomyocardial Biopsy -- 9.6.1 Case I (J.D.) -- 9.6.2 Case II (C.P.) -- 9.6.3 Case III (C.S.) -- 9.6.4 Case IV (C.F.) -- References -- 10: Arrhythmias in Dilated Cardiomyopathy: Diagnosis and Treatment -- 10.1 Burden and Kinds of Arrhythmias in Dilated Cardiomyopathy: Risk Stratification of Sudden Death -- 10.1.1 Bradyrhythmias and Conduction Abnormalities -- 10.1.2 Supraventricular Arrhythmias. , 10.1.3 Ventricular Arrhythmias -- 10.1.4 Mechanisms -- 10.1.5 Risk Stratification of Sudden Cardiac Death -- 10.1.6 Role of Supraventricular and Ventricular Arrhythmias in Pathogenesis of DCM -- 10.1.6.1 Definition and Pathophysiology -- 10.1.6.2 Specific Clinical Pictures -- 10.1.7 Management of Atrial Arrhythmias in Dilated Cardiomyopathy and Heart Failure -- 10.1.8 Management of Ventricular Arrhythmias in Dilated Cardiomyopathy -- 10.1.9 Antiarrhythmic Drug Therapy of Ventricular Arrhythmias -- 10.1.10 Catheter Ablation of Ventricular Arrhythmias -- 10.1.11 Characteristics of the Arrhythmogenic Substrate and Its Impact on Catheter Ablation Approach -- 10.1.12 Role of ICD in DCM -- References -- 11: Regenerative Medicine and Biomarkers for Dilated Cardiomyopathy -- 11.1 Strategies for Heart Regeneration -- 11.1.1 Cell Therapy -- 11.1.2 Gene Therapy -- 11.2 Regenerative Approaches in Dilated Cardiomyopathy -- 11.3 Biomarkers and Dilated Cardiomyopathy -- References -- 12: Prognostic Stratification and Importance of Follow-Up -- 12.1 Prognosis of DCM: The Milestones of the Management -- 12.2 Etiological Characterization as an Important Prognostic Factor -- 12.3 DCM as a Dynamic Disease: The Importance of Follow-Up -- 12.4 Left Ventricular Reverse Remodeling Beyond the Left Ventricle -- 12.5 Prognostic Role of Cardiopulmonary Exercise Testing -- 12.6 Arrhythmic Risk Stratification -- 12.7 The "Apparent Healing" Phenomenon -- 12.8 Uninterrupted Follow-Up and Continuous Reclassification of the Disease -- References -- 13: Current Management and Treatment -- 13.1 Familial Screening Program -- 13.2 Sport Activity Screening Program -- 13.3 Medical Treatment -- 13.4 Ventricular and Supraventricular Arrhythmias -- 13.5 Implantable Cardioverter-Defibrillator -- 13.6 Cardiac Resynchronization Therapy. , 13.7 Advanced Heart Failure, Mechanical Circulatory Support, Functional Mitral Regurgitation Correction, Heart Transplantation, and Palliative Care -- References -- 14: Unresolved Issues and Future Perspectives -- 14.1 Toward a Personalized Medicine: A Genetic Approach -- 14.2 The Challenge of Arrhythmic Stratification -- 14.3 Toward Innovation in Therapy -- References -- 15: Dilated Cardiomyopathy at the Crossroad: Multidisciplinary Approach -- 15.1 Sarcoidosis: Co-working with Pneumologists -- 15.1.1 Treatment -- 15.2 Autoimmune Cardiomyopathy: Co-working with Rheumatologists -- 15.2.1 Systemic Lupus Erythematosus -- 15.2.2 Treatment -- 15.3 Infectious Disease and Cardiomyopathy: Co-working with Infectious Disease Specialist -- 15.3.1 Chagas Cardiomyopathy -- 15.3.2 Treatment -- 15.3.3 Lyme Disease -- 15.3.4 Treatment -- 15.4 Dilated Cardiomyopathy Associated with Neuromuscular Diseases: Co-working with Neurologists -- 15.5 Primary Iron-Overload Cardiomyopathy: Co-working with the Hematologists -- 15.6 Cardiomyopathy Related to Chemotherapeutic Agents: Co-working with Oncologists -- 15.6.1 Treatment -- 15.7 Alcoholic Cardiomyopathy -- 15.7.1 Treatment -- References.

Additional Edition: Print version: Sinagra, Gianfranco Dilated Cardiomyopathy Cham : Springer International Publishing AG,c2019 ISBN 9783030138639

Language: English

Subjects: Medicine

Keywords: Electronic books.

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URL: https://doi.org/10.1007/978-3-030-13864-6

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UID:

Format: 1 online resource (IX, 241 p. 55 illus., 45 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-13864-X

Content: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease. .

Note: 1 Introduction -- 2 Epidemiology -- 3 Pathophysiology -- 4 Etiological definition and diagnostic work-up -- 5 Role of genetics and environmental factors -- 6 Clinical presentation, spectrum of disease, natural history -- 7 Role of cardiac imaging: echocardiography -- 8 Role of cardiac imaging: cardiac magnetic resonance and computed tomography -- 9 Endomyocardial biopsy -- 10 Arrhythmias in dilated cardiomyopathies -- 11 Regenerative Medicine and dilated cardiomyopathy -- 12 Prognostic stratification and importance of follow-up -- 14 Current management and treatment -- 14 Open issues and future perspectives -- 15 Dilated cardiomyopathy at the cross road: multidisciplinary approach. , English

Additional Edition: ISBN 3-030-13863-1

Language: English

DOI: 10.1007/978-3-030-13864-6

UID:

Format: 1 online resource (IX, 241 p. 55 illus., 45 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-13864-X

Content: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease. .

Note: 1 Introduction -- 2 Epidemiology -- 3 Pathophysiology -- 4 Etiological definition and diagnostic work-up -- 5 Role of genetics and environmental factors -- 6 Clinical presentation, spectrum of disease, natural history -- 7 Role of cardiac imaging: echocardiography -- 8 Role of cardiac imaging: cardiac magnetic resonance and computed tomography -- 9 Endomyocardial biopsy -- 10 Arrhythmias in dilated cardiomyopathies -- 11 Regenerative Medicine and dilated cardiomyopathy -- 12 Prognostic stratification and importance of follow-up -- 14 Current management and treatment -- 14 Open issues and future perspectives -- 15 Dilated cardiomyopathy at the cross road: multidisciplinary approach. , English

Additional Edition: ISBN 3-030-13863-1

Language: English

DOI: 10.1007/978-3-030-13864-6

UID:

Format: 1 online resource (IX, 241 p. 55 illus., 45 illus. in color.)

Edition: 1st ed. 2019.

ISBN: 3-030-13864-X

Content: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease. .

Note: 1 Introduction -- 2 Epidemiology -- 3 Pathophysiology -- 4 Etiological definition and diagnostic work-up -- 5 Role of genetics and environmental factors -- 6 Clinical presentation, spectrum of disease, natural history -- 7 Role of cardiac imaging: echocardiography -- 8 Role of cardiac imaging: cardiac magnetic resonance and computed tomography -- 9 Endomyocardial biopsy -- 10 Arrhythmias in dilated cardiomyopathies -- 11 Regenerative Medicine and dilated cardiomyopathy -- 12 Prognostic stratification and importance of follow-up -- 14 Current management and treatment -- 14 Open issues and future perspectives -- 15 Dilated cardiomyopathy at the cross road: multidisciplinary approach. , English

Additional Edition: ISBN 3-030-13863-1

Language: English

DOI: 10.1007/978-3-030-13864-6

UID:

Format: IX, 241 p. 55 illus., 45 illus. in color. , online resource.

Edition: 1st ed. 2019.

ISBN: 9783030138646

Content: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease. .

Note: 1 Introduction -- 2 Epidemiology -- 3 Pathophysiology -- 4 Etiological definition and diagnostic work-up -- 5 Role of genetics and environmental factors -- 6 Clinical presentation, spectrum of disease, natural history -- 7 Role of cardiac imaging: echocardiography -- 8 Role of cardiac imaging: cardiac magnetic resonance and computed tomography -- 9 Endomyocardial biopsy -- 10 Arrhythmias in dilated cardiomyopathies -- 11 Regenerative Medicine and dilated cardiomyopathy -- 12 Prognostic stratification and importance of follow-up -- 14 Current management and treatment -- 14 Open issues and future perspectives -- 15 Dilated cardiomyopathy at the cross road: multidisciplinary approach.

In: Springer eBooks

Additional Edition: Printed edition: ISBN 9783030138639

Additional Edition: Printed edition: ISBN 9783030138653

Additional Edition: Printed edition: ISBN 9783030138660

Language: English

DOI: 10.1007/978-3-030-13864-6

URL: https://doi.org/10.1007/978-3-030-13864-6

UID:

Format: 1 online resource : , illustrations

ISBN: 9783030138639 , 3030138631 , 9783030138646 , 303013864X , 9783030138653 , 3030138658 , 9783030138660 , 3030138666

Series Statement: Online access: OAPEN DOAB Directory of Open Access Books.

Uniform Title: Dilated cardiomyopathy (Sinagra)

Content: Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by left ventricular or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfunction. DCM is currently a relatively benign disease, with concrete treatment strategies and solid therapeutic regimens. However, clinical management of DCM patients is still one of the most challenging scenarios even for tertiary referral centers. DCM patients are usually young (between their 30s and 50s), still of working age with usually a solid economic and social background. Several pitfalls may be present during diagnostic workup and risk stratification of these patients. First of all, DCM is usually a mostly genetically determined disease. Indeed, the novel techniques of DNA sequencing revealed that genetically determined DCMs are vastly more common than once believed and it is far from being a monogenic disease, with multiple unknown epigenetic interactions. The incomplete penetrance and the epigenetic regulations are responsible for the so-called genotype-positive-phenotype-negative patients. Therefore, the management of information derived from genetic testing, both for probands and for relatives, is still debated and not definite. The continuous effort of researchers to identify the mechanism underlying the disease is fundamental to improving the survival of those patients.

Note: 1 Introduction -- 2 Epidemiology -- 3 Pathophysiology -- 4 Etiological definition and diagnostic work-up -- 5 Role of genetics and environmental factors -- 6 Clinical presentation, spectrum of disease, natural history -- 7 Role of cardiac imaging: echocardiography -- 8 Role of cardiac imaging: cardiac magnetic resonance and computed tomography -- 9 Endomyocardial biopsy -- 10 Arrhythmias in dilated cardiomyopathies -- 11 Regenerative Medicine and dilated cardiomyopathy -- 12 Prognostic stratification and importance of follow-up -- 14 Current management and treatment -- 14 Open issues and future perspectives -- 15 Dilated cardiomyopathy at the cross road: multidisciplinary approach.

In: Springer eBooks

Additional Edition: Print version: Sinagra, Gianfranco. Dilated Cardiomyopathy : From Genetics to Clinical Management. Cham : Springer, ©2019 ISBN 9783030138639

Language: English

Keywords: Electronic books. ; Index not Present.

DOI: 10.1007/978-3-030-13864-6

URL: http://www.ncbi.nlm.nih.gov/books/NBK553850/

URL: ProQuest Ebook Central

URL: SpringerLink

URL: https://link.springer.com/10.1007/978-3-030-13864-6

URL: http://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9783030138646

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