Format:
1 Online-Ressource(XVI, 113 p.)
Edition:
1st ed. 2011.
ISBN:
9783031016509
Series Statement:
Synthesis Lectures on Biomedical Engineering
Content:
Genome Signatures, Definition and Background -- Other Computational Characterizations as Genome Signatures -- Measuring Distance of Biological Sequences Using Genome Signatures -- Applications: Phylogeny Construction -- Applications: Metagenomics -- Applications: Horizontal DNA Transfer Detection.
Content:
Recent advances in development of sequencing technology has resulted in a deluge of genomic data. In order to make sense of this data, there is an urgent need for algorithms for data processing and quantitative reasoning. An emerging in silico approach, called computational genomic signatures, addresses this need by representing global species-specific features of genomes using simple mathematical models. This text introduces the general concept of computational genomic signatures, and it reviews some of the DNA sequence models which can be used as computational genomic signatures. The text takes the position that a practical computational genomic signature consists of both a model and a measure for computing the distance or similarity between models. Therefore, a discussion of sequence similarity/distance measurement in the context of computational genomic signatures is presented. The remainder of the text covers various applications of computational genomic signatures in the areas of metagenomics, phylogenetics and the detection of horizontal gene transfer. Table of Contents: Genome Signatures, Definition and Background / Other Computational Characterizations as Genome Signatures / Measuring Distance of Biological Sequences Using Genome Signatures / Applications: Phylogeny Construction / Applications: Metagenomics / Applications: Horizontal DNA Transfer Detection.
Additional Edition:
ISBN 9783031005220
Additional Edition:
ISBN 9783031027789
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9783031005220
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9783031027789
Language:
English
DOI:
10.1007/978-3-031-01650-9
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