Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9783034602266
Content:
GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.
Note:
Includes bibliographical references and index
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GABA and Sleep; Foreword; Preface; About the Editors; Credits and Acknowledgements; Contents; List of Contributors; Part I Basic Physiology and Pharmacology; Physiology and Pharmacology of the GABA System: Focus on GABA Receptors; 1 Neural Oscillations and GABA; 2 Role of GABA Receptors; 3 GABAA Receptors and their Multiplicity; 4 Benzodiazepine-Sensitive GABAA Receptors; 5 The Benzodiazepine Site, a Servo Mechanism for Inhibition; 6 Diazepam-Insensitive GABAA Receptors; 7 GABAA Receptors and Sleep Promotion; 8 GABAA Receptor Subtypes and EEG Patterns
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9 Role of α3GABAA Receptor Subtypes in the Arousal Systems10 Role of delta GABAA Receptors and Gaboxadol (THIP); 11 Anxiolytic Activity Without Sedation; 12 Pain Suppression via Spinal α2/α3 GABAA Receptors; 13 Targeting Cognitive Impairment Through α5GABAA Receptors; 14 Cognitive Enhancement Through α2 and α3 GABAA Receptors; 15 Dependence Liability of GABAA Receptor Drugs; 16 GABAB Receptors; 16.1 Structure and Physiology of GABAB Receptors; 16.2 GABAB Receptors and Orexin Neurons; 16.3 GABAB Receptors as Target for Gamma-Hydroxybutyrate
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16.4 Pharmacology of GABAB Receptors Beyond NarcolepsyReferences; Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders; 1 Introduction; 1.1 GABAA Receptor Structure and Function; 1.2 GABAA Receptor Pharmacology; 1.2.1 GABA Binding Site; 1.2.2 Benzodiazepine Binding Site; 1.2.3 Neurosteroid Binding Site; 1.2.4 Convulsant Binding Site; 1.2.5 Barbiturate Binding Site; 1.2.6 beta Subunit Binding Site(s); 1.3 Subtype-Selective Affinity and Subtype-Selective Efficacy; 2 GABAA Receptor Compounds for Anxiety; 2.1 Anxiety Disorders and Benzodiazepines
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2.2 Benzodiazepine Site Modulators: Pre-clinical Compounds2.3 Benzodiazepine Site Modulators: Clinical Compounds; 2.3.1 Ocinaplon; 2.3.2 SL65.1498; 2.3.3 Pagoclone; 2.3.4 ELB-139; 2.3.5 Merck Compounds; 2.4 Additional Properties Of Non-Sedating Anxiolytics; 2.5 Summary of GABAA Receptors as a Target for Anxiety Disorders; 3 GABAA Receptor Compounds for Sleep Disorders; 3.1 Insomnia; 3.2 Marketed Non-Benzodiazepine GABAA-Modulating Hypnotics: The ``Z-Drugs´´; 3.3 Non-Benzodiazepine GABAA-Modulating Hypnotics in Clinical Development; 3.3.1 Adipiplon; 3.3.2 Indiplon; 3.3.3 EVT-201
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3.3.4 Gaboxadol3.4 Summary of GABAA Receptors as a Target for Hypnotics; 4 Epilepsy; 4.1 Use of Benzodiazepines in the Treatment of Epilepsy; 4.2 Novel Pre-clinical Benzodiazepine Site Modulator: ELB-138; 4.3 Neurosteroids: Ganaxolone; 4.4 Summary of GABAA Receptors as a Target for Epilepsy; 5 Overall Summary; References; Distribution of GABAA Receptor Subunits in the Human Brain; 1 Introduction; 2 Subunit Localisation; 2.1 Cerebral Cortex; 2.2 Hippocampus; 2.3 Thalamus; 2.4 Basal Ganglia; 2.4.1 Striatum; 2.4.2 Globus Pallidus; 2.4.3 Midbrain; 2.4.4 Brainstem; 2.4.5 Spinal Cord
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3 Overall Distribution
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Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9783034602259
Language:
English
DOI:
10.1007/978-3-0346-0226-6
URL:
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