Format:
Online-Ressource (XIII, 447p. 42 illus., 14 illus. in color, digital)
Edition:
First
ISBN:
9783034602778
Series Statement:
Birkhäuser Advances in Infectious Diseases
Content:
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new ty
Note:
Includes bibliographical references and index
,
Replicating Vaccines; Preface; Contents; Contributors; Part I Today´s Live Attenuated Vaccines; Live Vaccines and Their Role in Modern Vaccinology; Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus; Classical Live Viral Vaccines; Part II Genetically Attenuated Micro-Organisms as Vaccines; Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus; Live-Attenuated Shigella Vaccines. Is Encouraging Good Enough?; New Generation BCG Vaccines; Part III Manipulating Host-Pathogen Interactions to Make Vaccines
,
Basic Science Paves the Way to Novel Safe and Effective Pestivirus VaccinesLive Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation; An Attenuated HSV-1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell-to-Cell and Neuronal Spread; Live Attenuated Vaccines for Respiratory Syncytial Virus; Live Attenuated Cholera Vaccines: Flagella and Reactogenicity; Part IV New Types of Replicating Vaccines; Replication-Defective Herpes Simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors
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Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus VaccinesApplication of Cleavage Activation Mutants of Influenza Virus as Live Vaccines; Alphavirus Particle-Based Vaccine Vectors; Recombinant, Chimeric, Live, Attenuated Vaccines Against Flaviviruses and Alphaviruses; Index
Additional Edition:
ISBN 9783034602761
Additional Edition:
Buchausg. u.d.T. Replicating vaccines Basel : Springer, 2011 ISBN 9783034602761
Additional Edition:
ISBN 3034602766
Language:
English
DOI:
10.1007/978-3-0346-0277-8
URL:
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