Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (172p.)

ISBN: 9783110249484

Series Statement: Patient Safety ; 3

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardizatio

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Deep knowledge of basic principles of immunochemical methods, sources of analyte-independent interferences and analyte-dependent interferences are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results, improve patient's care and patient's safety.

Note: Frontmatter -- , Contents -- , Preface -- , Abbreviations -- , Part I Immunoassay: Theory, practice, and patient safety -- , 1 Immunochemical methods – Basic principles and definitions -- , 2 Immunoassay standardization -- , 3 Immunoassay calibration and calibration curve fitting -- , 4 Reference intervals and immunoassay -- , 5 Laboratory preanalytical and analytical phase of immunoassay -- , 6 Human natural antibodies and immunoassay -- , 7 Immunoassay interference – How to recognize, eliminate, or reduce it -- , 8 Immunoassay and patient safety -- , Part II Immunochemistry measurements in practice: Examples of problems in some current immunoassays -- , Example 1 Parathyroid hormone (PTH) – Heterogeneity as a major problem in PTH measurement by immunochemistry -- , Example 2 Human chorionic gonadotropin (hCG) – Problems of heterogeneity and lack of standardization -- , Example 3 Troponin measurement by immunoassay – Problem of low assay sensitivity and interference from heterophilic antibodies -- , Example 4 Aldosterone and proteolytic renin activity (PRA) – Are they useful together? -- , Example 5 Thyroglobulin measurement – Autoantibody problem -- , Example 6 Prolactin measurement by immunoassay – Heterogeneity and macroform problems -- , Example 7 Thyroid function tests – Most frequently measured and most difficult to interpret: Reference interval for thyroidstimulating hormone (TSH) and problems of free thyroid hormone fraction measurement -- , Index , In English.

Language: English

DOI: 10.1515/9783110249484

URL: https://doi.org/10.1515/9783110249484

URL: Volltext  (lizenzpflichtig)

URL: Volltext  (URL des Erstveröffentlichers)

URL: https://doi.org/10.1515/9783110249484

URL: https://www.degruyter.com/isbn/9783110249484

URL: Cover

UID:

Format: Online-Ressource

Edition: Online-Ausg. 2011 Electronic reproduction; Available via World Wide Web

ISBN: 9783110249477

Series Statement: Patient Safety 3

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Deep knowledge of basic principles of immunochemical methods, sources of analyte-independent interferences and analyte-dependent interferences are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results, improve patient's care and patient's safety.Krystyna Sztefko, Jagiellonian University, Krakow, Poland.

Note: Includes bibliographical references and index , Immunochemical methods : basic principle and definitions -- Immunoassay standardization -- Immunoassay calibration and calibration curve-fitting -- Reference intervals and immunoassay -- Laboratory pre-analytical and analytical phase of immunoassay -- Human natural antibodies and immunoassay -- Immunoassay interferences : how to recognize, eliminate, or reduce them -- Immunoassay and patient safety..

Additional Edition: ISBN 9783110249484

Language: English

DOI: 10.1515/9783110249484

URL: http://www.degruyter.com/doi/book/10.1515/9783110249484

URL: Cover

UID:

Format: 1 online resource (172p.)

ISBN: 9783110249484

Series Statement: Patient Safety ; 3

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardizatio

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Deep knowledge of basic principles of immunochemical methods, sources of analyte-independent interferences and analyte-dependent interferences are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results, improve patient's care and patient's safety.

Note: Frontmatter -- , Contents -- , Preface -- , Abbreviations -- , Part I Immunoassay: Theory, practice, and patient safety -- , 1 Immunochemical methods – Basic principles and definitions -- , 2 Immunoassay standardization -- , 3 Immunoassay calibration and calibration curve fitting -- , 4 Reference intervals and immunoassay -- , 5 Laboratory preanalytical and analytical phase of immunoassay -- , 6 Human natural antibodies and immunoassay -- , 7 Immunoassay interference – How to recognize, eliminate, or reduce it -- , 8 Immunoassay and patient safety -- , Part II Immunochemistry measurements in practice: Examples of problems in some current immunoassays -- , Example 1 Parathyroid hormone (PTH) – Heterogeneity as a major problem in PTH measurement by immunochemistry -- , Example 2 Human chorionic gonadotropin (hCG) – Problems of heterogeneity and lack of standardization -- , Example 3 Troponin measurement by immunoassay – Problem of low assay sensitivity and interference from heterophilic antibodies -- , Example 4 Aldosterone and proteolytic renin activity (PRA) – Are they useful together? -- , Example 5 Thyroglobulin measurement – Autoantibody problem -- , Example 6 Prolactin measurement by immunoassay – Heterogeneity and macroform problems -- , Example 7 Thyroid function tests – Most frequently measured and most difficult to interpret: Reference interval for thyroidstimulating hormone (TSH) and problems of free thyroid hormone fraction measurement -- , Index , In English.

Language: English

DOI: 10.1515/9783110249484

URL: https://doi.org/10.1515/9783110249484

UID:

Format: 1 Online-Ressource (X, 162 S.) : , Ill., graph. Darst.

ISBN: 978-1-283-16628-7 , 978-3-11-024948-4

Series Statement: Patient Safety 3

Note: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Deep knowledge of basic principles of immunochemical methods, sources of analyte-independent interferences and analyte-dependent interferences are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results, improve patient's care and patient's safety.Krystyna Sztefko, Jagiellonian University, Krakow, Poland

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-11-024947-7

Language: English

Keywords: Immunassay ; Patient ; Sicherheit

DOI: 10.1515/9783110249484

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 online resource (176 p.)

Edition: 1st ed.

ISBN: 1-283-16628-3 , 9786613166289 , 3-11-024948-0

Series Statement: Patient safety ; v. 3

Content: Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.

Note: Description based upon print version of record. , Immunochemical methods : basic principle and definitions -- Immunoassay standardization -- Immunoassay calibration and calibration curve-fitting -- Reference intervals and immunoassay -- Laboratory pre-analytical and analytical phase of immunoassay -- Human natural antibodies and immunoassay -- Immunoassay interferences : how to recognize, eliminate, or reduce them -- Immunoassay and patient safety. , English

Additional Edition: ISBN 3-11-024947-2

Language: English

DOI: 10.1515/9783110249484