UID:
edocfu_9958076728002883
Umfang:
1 online resource (282 p.)
ISBN:
1-280-70966-9
,
9786610709663
,
3-318-01393-5
,
1-4294-6838-6
Serie:
Contributions to nephrology, v. 152
Inhalt:
It is essential for the survival of cells to maintain their volume within certain limits: Profound alterations interfere with the integrity of the cell membrane and the cytoskeletal architecture. Cells use various methods to adjust osmotic pressure gradients which in turn govern water movement across cell membranes. The most rapid and efficient means is ion transport across the cell membrane. However, to avoid excessive alterations of intracellular ion concentration, cells additionally employ organic osmolytes for osmoregulation and modify their metabolism, thus generating or disposing osmotically active organic substances. But a given cell uses only part of the cell volume regulatory mechanisms at their disposal: The large repertoire available allows for a selection of those which have the least untoward impact on cell function. The present book is a collection of reviews on the various aspects of cell volume regulation, written by internationally leading experts, and constitutes a valuable addition to the library of those working in the field.
Anmerkung:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Cell Volume Regulatory Mechanisms""; ""Abstract""; ""Cell Volume Regulatory Ion Transport""; ""Organic Osmolytes""; ""References""; ""Cell Volume-Sensitive Chloride Channels: Phenotypic Properties and Molecular Identity""; ""Abstract""; ""Regulatory Volume Decrease and Cl- Channels""; ""Phenotypic Properties of Human Epithelial VSOR Cl- Channels""; ""Volume-Sensitive, Outwardly Rectifying, ATP-Dependent Cl- Channel""; ""The Molecular Identity of VSOR Cl- Channel""; ""Physiological and Pathological Significance""; ""References""
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""Cell Volume-Regulated Cation Channels""""Abstract""; ""RVI, the Activation of Cation Channels""; ""RVI, the Inhibition of K+ Channels""; ""RVD, the Activation of K+ Channels""; ""RVD, the Activation of Cation Channels""; ""Phospholemman""; ""Conclusion""; ""Acknowledgement""; ""References""; ""Sensors and Signal Transduction Pathways in Vertebrate Cell Volume Regulation""; ""Abstract""; ""Physiological Relevance of Cell Volume Regulation""; ""Swelling-Activated Membrane Transport Systems""; ""Swelling-Activated K+ Channels""; ""Activation of IK,vol by Cell Swelling""
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""Swelling-Activated Anion Current""""Activation of ICl,vol by Cell Swelling""; ""Swelling-Activated Taurine Efflux""; ""Regulation of the Taurine Efflux Pathway by Cell Swelling""; ""Swelling-Activated KCl Cotransport""; ""Activation of KCC by Cell Swelling""; ""Shrinkage-Activated Membrane Transport Systems""; ""The Na+/H+ Exchangers""; ""Regulation of NHE1 by Cell Shrinkage""; ""The Na+, K+, 2Cl+ Cotransporter""; ""Regulation of NKCC1 by Cell Shrinkage""; ""Hypertonicity-Induced Cation Channels""; ""Shrinkage-Induced Activation of HICCs""; ""Volume Sensing Pathways: Novel Players""
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""How May a Membrane Protein Sense Cell Volume Perturbations?""""Integrins and Growth Factor Receptors as Volume Sensors?""; ""Integrins""; ""Growth Factor Receptors""; ""Other Upstream Mechanisms in Volume Sensing""; ""Transient Receptor Potential Channels""; ""Phospholipase A2""; ""Reactive Oxygen Species""; ""Small GTP-Binding Proteins and Their Effectors""; ""Cytoskeletal Rearrangement""; ""Role of the Cytoskeleton in Regulation of Osmolyte Transport in RVD and RVI""; ""Tyrosine Kinases:FAK and Src Family Kinases""
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""Ser/Thr Protein Kinases:Ste20 Related Kinases and With-No-Lysine (K)Kinases""""Mitogen-Activated Protein Kinases""; ""Acknowledgements""; ""References""; ""Activation of Kinases upon Volume Changes: Role in Cellular Homeostasis""; ""Abstract""; ""Regulatory Volume Decrease""; ""K+ Channels""; ""Cl- Channels""; ""K-Cl Cotransport""; ""Organic Osmolyte Efflux""; ""Regulatory Volume Increase""; ""Na+/H+ Exchange""; ""Na+/K+/2Cl- Symport""; ""TonEBP and the Late Response to Hypertonicity""; ""Concluding Remarks""; ""References""
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""Tonicity-Dependent Regulation of Osmoprotective Genes in Mammalian Cells""
,
English
Weitere Ausg.:
ISBN 3-8055-8174-2
Sprache:
Englisch
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