Umfang:
Online-Ressource (V, 92 p. 39 illus., 9 illus. in color, digital)
ISBN:
9783319003030
Serie:
SpringerBriefs in Molecular Science
Inhalt:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the des
Anmerkung:
Includes bibliographical references and index
,
Iron Acquisition by the Genus Mycobacterium; Contents; 1 Introduction to the Book; 1.1 The Value, Danger, and Capture of Iron by Bacteria; 1.2 Scope of the Book; 2 A History of Iron Metabolism in the Mycobacteria; Abstract; 2.1 Introduction; 2.2 The Trouble with Iron; 2.3 Iron as an Essential Nutrient for Mycobacteria; 2.4 Early Discoveries of the Major Components of Iron Acquisition by Mycobacteria; 2.4.1 The Mycobactins; 2.4.2 Other Mycobactins and Related Lipid-Soluble Siderophores; 2.4.3 Salicylic Acid; 2.5 Extracellular Siderophores of Mycobacteria; 2.5.1 The Problem with Mycobactin
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2.5.2 The Water-Soluble Exochelins2.5.3 The Carboxymycobactins; 2.6 Putting it All Together; References; 3 Mycobacterial Iron Acquisition Mechanisms; Abstract; 3.1 The Need for Siderophores in Iron Acquisition; 3.2 The "Iron Biofulcrum" of Infectious Diseases; 3.3 The Mycobacterial Siderophores and Iron Acquisition: Mycobactin, Carboxymycobactin, and Exochelin; 3.4 Mycobacterial Iron Acquisition from Heme; 3.5 Ferritin and Mycobacterial Persistence in Animals; 3.6 Low Affinity and Reductive Mycobacterial Iron Acquisition
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3.7 Iron and Continuous Growth of M. smegmatis in a Teflon Chemostat: Biofilm Formation3.8 The Complexity and Perplexity of Mycobacterial Iron Acquisition: Conclusions; References; 4 Siderocalin Combats Mycobacterial Infections; Abstract; 4.1 Siderocalin; 4.2 Role of Siderophores in Mycobacterial Infections; 4.3 Scn Binds Carboxymycobactins; 4.4 Scn Location and Contact with Mycobacteria; 4.5 Concluding Remarks; References; 5 Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis; Abstract; 5.1 Introduction
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5.2 Bacterial Iron Acquisition5.3 Siderophore System in M. tuberculosis; 5.4 Siderophore-Antibiotic Conjugates; 5.5 Mycobactin Analogs are Growth Inhibitors of M. tuberculosis; 5.6 Small Molecule Anti-TB Agents Derived from Studies of the Oxazoline Component of Mycobactins; 5.7 A Mycobactin Siderophore-Antibiotic Conjugate Selectively Targets M. tuberculosis; 5.8 Inhibition of MbtA Nonribosomal Peptide Synthetase; 5.9 Inhibition of MbtI Nonribosomal Peptide Synthetase; 5.10 Conclusions; References; Index
Weitere Ausg.:
ISBN 9783319003023
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Iron acquisition by the genus mycobacterium Cham : Springer, 2013 ISBN 9783319003023
Sprache:
Englisch
DOI:
10.1007/978-3-319-00303-0
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