Umfang:
Online-Ressource (XIV, 469 p. 72 illus., 43 illus. in color, online resource)
ISBN:
9783319013121
Serie:
SpringerLink
Inhalt:
This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described also in depth over many chapters. Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling. Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Anmerkung:
Includes bibliographical references and index
,
Preface; Contents; Contributors; Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells; 1 Introduction; 2 Expression of RyRs and IP3Rs; 3 RyR- and IP3R-Mediated Ca2+ Release; 4 Interaction of RyRs and IP3Rs with Other Ion Channels; 4.1 Transient Receptor Potential (TRP) Channels; 4.2 Big-Conductance Ca2+-Activated K+ Channels (BKCa); 4.3 Ca2+-Activated Cl-- (ClCa) Channels; 5 Regulation of RyRs and IP3Rs; 5.1 Regulators of RyRs; 5.2 Regulators of IP3R; 6 Physiological and Pathological Functions of RyRs and IP3Rs in Airway SMCs; 6.1 Role of RyRs
,
6.2 Role of IP3Rs6.3 Cyclic Adenosine Diphosphate Ribose (cADPR)/CD38; 7 Conclusion and Perspective; References; Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter; 1 L-type VSCCs in Airway Smooth Muscle Cells; 2 CCBs in Asthma Therapy; 3 Kv7 Potassium Channels in Airway Smooth Muscle Cells; 4 Prospects for Future Developments; 5 Summary; References; Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells; 1 Introduction; 2 Expression of TRPs, Orais, and Stims; 2.1 General Structural Properties of Mammalian TRP Channels
,
2.2 TRPC Channels2.3 TRPV1, TRPV2, and TRPV4 Channels; 2.4 Other TRP Channels; 2.5 Orai Channels; 2.6 Stim Proteins; 3 Physiological Functions of TRPs, Orais, and Stims; 3.1 Controlling the Resting Membrane Potential and [Ca2+]i in ASMCs; 3.2 Regulation of [Ca2+]i in ASMCs; 4 Functional Roles of TRPs, Orais, and Stims in Respiratory Diseases; 4.1 Asthma; 4.2 Chronic Obstructive Pulmonary Disease; 4.3 Other Diseases; 5 Conclusion; References; Large-Conductance Calcium-Activated Potassium Channels; 1 Introduction; 2 Structure and Function of BKCa Channels; 2.1 α-Subunits; 2.2 beta-subunits
,
3 Effects of Outward K+ Currents on Smooth Muscle Tone4 Electrophysiological Characteristics of BKCa Channels; 4.1 Single-Channel Recording; 4.2 Whole-Cell Clamp Recording; 5 Chemical Modulation of BKCa Channels; 5.1 Effects Mediated Through Ca2+ Release; 5.2 Stimulatory Effects Mediated by beta-Adrenoceptor/G Protein/Cyclic Adenosine Monophosphate Processes; 5.3 Inhibitory Effects Mediated by Muscarinic Receptor/G Protein Processes; 5.4 Stimulatory Effects Mediated by Cyclic Guanosine Monophosphate Processes; 5.5 Regulation Mediated by Other Factors; 5.5.1 Protein Kinase C (PKC)
,
5.5.2 Estrogen5.5.3 Redox and Reactive Oxygen Species; 5.5.4 Arachidonic Acid; 5.5.5 Cholesterol; 5.5.6 NO, CO; 5.5.7 pH; 6 Effects of BKCa Channels on Physiological and Pathophysiological Conditions; 6.1 Pregnancy; 6.2 Development and Aging; 6.3 Hypoxia; 6.4 Shock; 6.5 Hypertension; 6.6 Diabetes; 6.7 Bronchial Asthma; 7 Conclusions; References; Calcium-Activated Chloride Channels; 1 Introduction; 2 Background: Importance of Membrane Potential and Chloride Flux in Airway Smooth Muscle Function; 3 Families of Chloride Channels and Functional Heterogeneity
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4 Electrophysiologic and Functional Identity of Calcium-Activated Chloride Channels
Weitere Ausg.:
ISBN 9783319013114
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe ISBN 978-331-90131-1-4
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Glatte Muskulatur
;
Calcium
;
Signalstoff
DOI:
10.1007/978-3-319-01312-1
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