UID:
almafu_9959328722002883
Format:
1 online resource (xxi, 413 pages) :
,
illustrations
ISBN:
3527605185
,
9783527605187
,
3527304312
,
9783527304318
,
3527602666
,
9783527602667
Series Statement:
Methods and principles in medicinal chemistry ; v. 21
Content:
Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. Appropriate for pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.
Note:
Cellular assays in drug discovery -- Gene knockout models -- Reporter gene assay systems for the investigation of G-proteincoupledReceptors -- From the human genome to new drugs: The potential of orphan G-proteincoupledReceptors -- Stereoselective synthesis with the help of recombinant enzymes -- Nucleic acid drugs -- Recent trends in enantioseparation of chiral drugs -- Affinity chromatography -- Nuclear magnetic resonance-based drug discovery -- 13C- and 15N-Isotopic labeling of proteins -- Application of antibody fragments as crystallization enhancers -- Pharmacogenetics: the effect of inherited genetic variation on drug disposition and drug response -- Pharmacogenomics of bioavailability and elimination -- Toxicogenomics: integration of new molecular biological tools in toxicology.
Additional Edition:
Print version: Molecular biology in medicinal chemistry. Weinheim : Wiley-VCH, ©2004 ISBN 3527304312
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527602666
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527602666
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527602666
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