UID:
almafu_9959329161402883
Format:
1 online resource (xxii, 369 pages) :
,
illustrations (some color)
ISBN:
3527312919
,
3527608761
,
9783527608768
,
9783527312917
,
9783527608607
,
3527608605
Series Statement:
Methods and principles in medicinal chemistry ; 34
Content:
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Note:
The concept of fragment-based drug discovery / Daniel A. Erlanson and Wolfgang Jahnke -- Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, and George M. Whitesides -- Entropic consequences of linking ligands / Christopher W. Murray and Marcel L. Verdonk -- Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe and Carla Mattos -- Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea and Jeffrey M. Blaney -- Structural fragments in marketed oral drugs / Michal Vieth and Miles Siegel -- Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz and Martin Karplus -- NMR-guided fragment assembly / Daniel S. Sem -- SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, and Chaohong Sun -- Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L.M. van Montfort, Glyn Williams, and Harren Jhoti -- Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, and Stephen K. Burley -- Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, and Vincent S. Stoll -- Ligand SAR using electrospray ionizing mass spectrometry / Richard H. Griffey and Eric E. Swayze -- Tethering / Daniel A. Erlanson, Marcus D. Ballinger, and James A. Wells -- Click chemistry for drug discovery / Stefanie Röper and Hartmuth C. Kolb -- Dynamic combinatorial diversity in drug discovery / Matthias Hochgürtel and Jean-Marie Lehn.
Additional Edition:
Print version: Fragment-based approaches in drug discovery. Weinheim : Wiley-VCH, ©2006 ISBN 3527312919
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527608761
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527608761
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/3527608761
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