Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (3 volumes) : , illustrations (some color)

ISBN: 9783527647767 , 3527647767 , 9783527634057 , 3527634053

Inhalt: In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A.

Anmerkung: Front Matter -- Principles of Tumor Targeting. Limits of Conventional Cancer Chemotherapy / Klaus Mross, Felix Kratz -- Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery / Peter Vaupel -- Enhanced Permeability and Retention Effect in Relation to Tumor Targeting / Hiroshi Maeda -- Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design / Jan Terje Andersen, Inger Sandlie -- Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates / Ruiwu Liu, Kai Xiao, Juntao Luo, Kit S Lam -- Antibody-Directed Enzyme Prodrug Therapy (ADEPT) -- Basic Principles and its Practice So Far / Kenneth D Bagshawe -- Tumor Imaging. Imaging Techniques in Drug Development and Clinical Practice / John C Chang, Sanjiv S Gambhir, Jurgen K Willmann -- Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery / Patrick D Sutphin, Efřn J Flores, Mukesh Harisinghani -- Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT / Andreas K Buck, Florian G̃rtner, Ambros Beer, Ken Herrmann, Sibylle Ziegler, Markus Schwaiger -- Macromolecular Drug Delivery Systems. Empowered Antibodies for Cancer Therapy / Stephen C Alley, Simone Jeger, Robert P Lyon, Django Sussman, Peter D Senter -- Mapping Accessible Vascular Targets to Penetrate Organs and Solid Tumors / Kerri A Massey, Jan E Schnitzer -- Considerations of Linker Technologies / Laurent Ducry -- Antibody-Maytansinoid Conjugates: From the Bench to the Clinic / Hans Erickson -- Calicheamicin Antibody-Drug Conjugates and Beyond / Puja Sapra, John Dijoseph, Hans-Peter Gerber -- Antibodies for the Delivery of Radionuclides / Anna M Wu -- Bispecific Antibodies and Immune Therapy Targeting / Sergej M Kiprijanov -- Design of Polymer-Drug Conjugates / Jindrich Kopecek, Pavla Kopeckov̀ -- Dendritic Polymers in Oncology: Facts, Features, and Applications / Mohiuddin Abdul Quadir, Marcelo Calder̤n, Rainer Haag -- Site-Specific Prodrug Activation and the Concept of Self-Immolation / Andř Warnecke -- Ligand-Assisted Vascular Targeting of Polymer Therapeutics / Anat Eldar-Boock, Dina Polyak, Ronit Satchi-Fainaro -- Drug Conjugates with Poly(Ethylene Glycol) / Hong Zhao, Lee M Greenberger, Ivan D Horak -- Thermo-Responsive Polymers / Drazen Raucher, Shama Moktan -- Polysaccharide-Based Drug Conjugates for Tumor Targeting / Gurusamy Saravanakumar, Jae Hyung Park, Kwangmeyung Kim, Ick Chan Kwon -- Serum Proteins as Drug Carriers of Anticancer Agents / Felix Kratz, Andreas Wunder, Bakheet Elsadek -- Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer / Coralie Deladriere, Rut Lucas, Mar̕a J Vicent -- Clinical Experience with Drug-Polymer Conjugates / Khalid Abu Ajaj, Felix Kratz -- Nano- and Microparticulate Drug Delivery Systems. Overview on Nanocarriers as Delivery Systems / Haifa Shen, Elvin Blanco, Biana Godin, Rita E Serda, Agathe K Streiff, Mauro Ferrari -- Development of PEGylated Liposomes / I Craig Henderson -- Immunoliposomes / Vladimir P Torchilin -- Responsive Liposomes (for Solid Tumor Therapy) / Stavroula Sofou -- Nanoscale Delivery Systems for Combination Chemotherapy / Barry D Liboiron, Paul G Tardi, Troy O Harasym, Lawrence D Mayer -- Micellar Structures as Drug Delivery Systems / Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka -- Tailor-Made Hydrogels for Tumor Delivery / Sungwon Kim, Kinam Park -- pH-Triggered Micelles for Tumor Delivery / Haiqing Yin, You Han Bae -- Albumin-Drug Nanoparticles / Neil Desai -- Carbon Nanotubes / David A Scheinberg, Carlos H Villa, Freddy Escorcia, Michael R McDevitt -- Ligand-Based Drug Delivery Systems. Cell-Penetrating Peptides in Cancer Targeting / Kaido Kurrikoff, Julia Suhorut, lo Langel -- Targeting to Peptide Receptors / Andrew V Schally, Gabor Halmos -- Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy / Zeyu Xiao, Jillian Frieder, Benjamin A Teply, Omid C Farokhzad -- Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors / Iontcho R Vlahov, Paul J Kleindl, Fei You -- Drug Conjugates with Polyunsaturated Fatty Acids / Joshua Seitz, Iwao Ojima -- Special Topics. RNA Drug Delivery Approaches / Yuan Zhang, Leaf Huang -- Local Gene Delivery for Therapy of Solid Tumors / Wolfgang Walther, Peter M Schlag, Ulrike Stein -- Viral Vectors for RNA Interference Applications in Cancer Research and Therapy / Henry Fechner, Jens Kurreck -- Design of Targeted Protein Toxins / Hendrik Fuchs, Christopher Bachran -- Drug Targeting to the Central Nervous System / Gert Fricker, Anne Mahringer, Melanie Ott, Valeska Reichel -- Liver Tumor Targeting / Katrin Hochd̲rffer, Giuseppina Di Stefano, Hiroshi Maeda, Felix Kratz -- Photodynamic Therapy: Photosensitizer Targeting and Delivery / Pawel Mroz, Sulbha K Sharma, Timur Zhiyentayev, Ying-Ying Huang, Michael R Hamblin -- Tumor-Targeting Strategies with Anticancer Platinum Complexes / Markus Galanski, Bernhard K Keppler -- Index.

Weitere Ausg.: Print version: Drug delivery in oncology. Weinheim : Wiley-VCH, ©2012 ISBN 9783527328239

Sprache: Englisch

Schlagwort(e): Electronic books.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527634057