Umfang:
Online-Ressource (XIV, 339p. 50 illus., 35 illus. in color, digital)
ISBN:
9783642003028
,
9783642003011
Serie:
Current Topics in Microbiology and Immunology 335
Inhalt:
〈P〉This introduction guides readers through different immunological aspects of autophagy as well as the countermeasures used by highly-adapted pathogens to fight autophagy. It includes specifics on the latest in autophagy research in infection and immunity.〈/P〉
Anmerkung:
Includes bibliographical references and index
,
Autophagy in Infection and Immunity; Preface; Contents; Contributors; An Overview of the Molecular Mechanism of Autophagy; 1 Introduction; 2 Molecular Mechanism of Autophagy; 2.1 Induction and Regulation of Autophagy; 2.2 The Cvt Pathway and Other Selective Types of Autophagy; 2.3 Phosphatidylinositol 3-Kinase Complex; 2.4 Two Ubiquitin-Like Protein Conjugation Systems; 2.5 Atg9 and Its Cycling Systems; 2.6 De Novo Vesicle Formation; 2.7 Vesicle Docking and Fusion with the Vacuole; 2.8 Vesicle Breakdown and Recycling of the Resulting Macromolecules; 3 Conclusion; References
,
Macroautophagy Signaling and Regulation1 Introduction; 2 Signaling Pathways; 2.1 TOR-Dependent Signaling Pathways; 2.1.1 mTORC1; 2.1.2 mTORC2; 2.1.3 Ampk; 2.1.4 Downstream Targets of mTOR; 2.2 mTOR-Independent Pathways; 2.3 Other Pathways; 2.3.1 eIF2.a. Kinases; 2.3.1.1 PERK; 2.3.1.2 PKR; 2.3.1.3 GCN2; 2.3.2 MAP Kinases; 2.3.2.1 p38.MAPK; 2.3.2.2 Extracellular Signal-Regulated Kinases; 2.3.2.3 c-Jun N-Terminal Kinases; 2.3.3 Protein Kinases C; 2.3.4 DAP Kinases; 2.3.5 Heterotrimeric G Proteins; 2.3.6 NF-.k.B; 2.3.7 Sphingolipids; 3 Autophagosome Formation; 3.1 Atg1 and Its Partners
,
3.2 Atg6/Beclin 13.2.1 Negative Regulators; 3.2.2 Positive Regulators; 3.3 Post-translational Modifications of Atg Proteins; 3.3.1 Ubiquitin-Like Conjugated Systems; 3.3.2 Atg4 and ROS; 3.3.3 Atg Acetylation; 3.4 Transcriptional Regulation of Atg Proteins; 3.5 The Cytoskeleton; 4 Maturation Step; 4.1 Morphology and Definition of Late Stages of Autophagy; 4.2 Regulation of the Maturation Events; 4.2.1 SNAREs; 4.2.2 Rab Proteins; 4.2.3 ATPases; 4.2.3.1 v-ATPases; 4.2.3.2 AAA ATPases; 4.2.4 ESCRT and Hrs; 4.2.5 Endo/lysosomal Proteins; 4.2.5.1 LAMP-2; 4.2.5.2 DRAM; 4.2.5.3 Recycling Molecules
,
4.2.6 Microtubules4.3 Signaling and Maturation of Autophagosomes; 4.3.1 MAPKs; 5 How Autophagy Can Be Manipulated; 6 Conclusions; References; Physiological Functions of Autophagy; 1 Introduction; 2 Physiological Functions of Autophagy; 2.1 Maintenance of the Amino Acid Pool; 2.2 Intracellular Quality Control; 2.3 Selective Degradation by Autophagy; 2.4 Development and Cell Death; 2.5 Tumor Suppression; 2.6 Anti-Aging; 3 Conclusion; References; Autophagy and Lymphocyte Homeostasis; 1 Introduction; 2 Regulation of T Cell Homeostasis by Cytokines and MHC/Peptide Ligands
,
2.1 Cytokines in T Cell Homeostasis2.2 TCR-MHC Interactions in T Cell Homeostasis; 3 Regulation of T Cell Homeostasis by the Intrinsic and Extrinsic Apoptotic Pathways; 3.1 Extrinsic Pathway Apoptosis in T Cell Homeostasis; 3.2 Intrinsic Apoptosis Pathway in T Cell Homeostasis; 4 Autophagy Induction in T Lymphocytes; 5 Autophagy: Dual Roles in T Cell Survival and Death; 5.1 Autophagy Contributes to Homeostatic T Cell Survival In Vivo; 5.2 Autophagy Contributes to T Cell Death; 5.3 Autophagy as a Paradoxical Mediator of Both Survival and Death in T Cells?; 6 Autophagy in T Cell Proliferation
,
6.1 Autophagosome Formation in T Cell Proliferation
Weitere Ausg.:
ISBN 9783642003011
Weitere Ausg.:
Buchausg. u.d.T. Autophagy in infection and immunity Dordrecht : Springer, 2009 ISBN 364200301X
Weitere Ausg.:
ISBN 9783642003011
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Autophagie
;
Cytologie
;
Autophagie
;
Immunologie
;
Autophagie
;
Infektiologie
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-00302-8
URL:
Volltext
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