Format:
Online-Ressource (XIII, 304p. 21 illus. in color, digital)
ISBN:
9783642141362
Series Statement:
Current Topics in Microbiology and Immunology 344
Content:
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Note:
Includes bibliographical references and index
,
Cancer Immunology and Immunotherapy; Preface; References; Contents; Contributors; Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control; 1 Introduction; 2 ``In Situ´´ Immune Contexture, the Strongest Prognostic Factor for Recurrence and Overall Survival: The Case of Colorectal Cancer; 3 Induction of Functionally Active Tertiary Lymphoid Structures in the Vicinity of Tumoral Beds as Potential Sites of ``In Situ Immune Reactions: The Example ofLung Carcinoma
,
4 Subversion of Innate Immunity Receptors: Stimulation of Toll Like Receptors on Lung Carcinoma Cells Modulates Cell Survival and Response to Chemotherapy5 ``Paradoxical´´ Control of Inflammation Influences Clinical Outcome in Head and Neck Cancer; 6 The Immune Reaction in a Tumor Developing in an Immuno-Priviledged Site: The Case of Primary Intraocular Lymphoma; 7 Conclusions; References; Subversion and Coercion: The Art of Redirecting Tumor Immune Surveillance; 1 Introduction; 2 The Inflammatory Trio: TNF-α, TGF-beta, IL-6
,
3 The Local Trigger: IL-23 and IL-12 Balance in the Tumor Microenvironment4 Feeding the Inflammatory Niche: Adaptive T Cell Responses Fostering the Tumor; 5 Turning Foes into Friends, CD8+ T Cells Lose Their Teeth; 6 Inflammatory Control at the Tumor Site; 7 Conclusions; References; STAT3: A Target to Enhance Antitumor Immune Response; 1 Introduction; 2 Stat3-Mediated Immune Suppression; 2.1 Inhibition of the Th1 Immune Response; 2.2 Relevant Immunologic Signaling Pathways; 2.3 Role in Myeloid Derived Suppressor Cells; 2.4 Role in Regulatory T-Cells; 3 Therapeutic Relevance
,
3.1 Genetic Evidence and Potential Toxicity3.2 JAK Inhibitors; 3.3 Other Oncogenic Kinase Inhibitors; 3.4 RTK Inhibitors; 3.5 siRNA; 4 Concluding Remarks; References; Biology and Clinical Observations of Regulatory T Cells in Cancer Immunology; 1 Introduction; 2 Treg Lineage and Development; 3 Treg Subsets; 3.1 Cell Surface Markers of Mouse Tregs; 3.2 Cell Surface Markers of Human Tregs; 3.3 Toll Like Receptors Expressed by Tregs; 3.4 Functional Subsets of Tregs; 3.5 Treg-Derived Malignancies; 4 Mechanisms of Treg-Mediated Immune Suppression in Cancer
,
4.1 Immunosuppressive Cytokines and Factors4.2 Suppression by Direct Cell-Cell Contact; 4.3 Treg-Mediated Cytotoxicity; 5 Clinical Observations of the Association of Tregs with Cancer; 6 Modification of Treg Biology as Cancer Immunotherapy; 6.1 The Cellular Microenvironment; 6.2 Strategies to Modulate Treg Number and Function; 6.3 Attenuating Treg Function; 7 Conclusions; References; Concepts and Ways to Amplify the Antitumor Immune Response; 1 Introduction; 2 Pharmacology of Tumor Cell-Immune Cell Interactions; 3 Tumor Cell Development and Its Danger Signals; 3.1 Neoplastic Cells
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3.2 Chronic Inflammation
Additional Edition:
ISBN 9783642141355
Additional Edition:
Buchausg. u.d.T. Cancer immunology and immunotherapy Heidelberg : Springer, 2011 ISBN 9783642141355
Language:
English
Subjects:
Medicine
Keywords:
Krebs
;
Immunologie
;
Immuntherapie
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-14136-2
URL:
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