Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9783642144264
Series Statement:
Results and Problems in Cell Differentiation 52
Content:
The prevalence of obesity has dramatically increased in western and westernized societies, making the disease the second leading cause of unnecessary deaths in the US. Obesity results from imbalanced metabolic regulation leading to excessive lipid storage. As important novel entities in metabolic regulation, taste receptors and their cells are critical elements that adapt the gustatory system to metabolic signals and vice versa. The role of taste receptor genes in gastrointestinal tissues, as well as their dynamic regulation in gustatory and non-gustatory tissues in response to metabolic cues, has become the focus of an entirely new and rapidly developing research field with impacts on fuel sensing, metabolic control, and ingestive behavior. This book reflects the recent scientific progress in the field of fuel sensing in the mouth, GI tract, and brain and examines the olfactory bulb as a potential metabolic sensor and the brain-gut endocrine axis. It also touches on relevant novel molecular and cellular mechanisms regulating lipid storage and metabolism and covers the identification and functional characterization of obesity genes. Lastly, it illustrates the use of insect models to study relevant problems of energy homeostasis.
Note:
Includes bibliographical references and index
,
Sensory and Metabolic Control of Energy Balance; Preface; Contents; The Genetic Basis of Obesity and Type 2 Diabetes: Lessons from the New Zealand Obese Mouse, a Polygenic Model of the Metabolic Syndrome; 1 Introduction; 1.1 Monogenic vs. Polygenic Traits; 1.2 The New Zealand Obese Mouse Model; 1 Overview and Discussion; 1.3 Consequences of Obesity on Glucose Homeostasis; 2 Identification of Gene Variants Responsible for Obesity and Diabetes in the NZO Mouse; 2.1 The Obesity Gene Tbc1d1 and Its Function as a Regulator of Substrate Oxidation in Skeletal Muscle
,
2.2 Zfp69, a Transcription Factor Associated with Altered Triglyceride Distribution and Enhanced Diabetes Susceptibility2.3 Identification of Other Candidates Potentially Contributing to Obesity and Diabetes in NZO; 2.3.1 Leptin Receptor (Lepr); 2.3.2 Phosphatidyl Choline Transfer Protein (Pctp); 2.3.3 ATP-binding Cassette Transporter G1 (Abcg1); 2.3.4 Neuromedin U Receptor 2 (Nmur2); 3 Conclusions and Future Perspectives; References; Regulation of Nutrient Metabolism and Inflammation; 1 General Introduction; 2 Common Endocrine and Transcriptional Regulators of Metabolism and Inflammation
,
2.1 Regulation of Metabolism and Immunity by Leptin2.2 Regulation of Metabolism and Immunity by Glucocorticoids; 2.3 Regulation of Metabolism and Immunity by PPARα; 3 Interaction Between Macrophages and Metabolically Active Cells in Liver and Adipose Tissue; 3.1 Role of Adipose Tissue Macrophages in Obesity; 3.2 Cross-talk Between Hepatocytes and Kupffer Cells; 4 Concluding Remarks; References; Lipid Storage in Large and Small Rat Adipocytes by Vesicle-Associated Glycosylphosphatidylinositol-Anchored Proteins; 1 Introduction
,
2 Lipogenic and Antilipolytic Information Transfer Between Adipocytes3 Conclusion; References; Autophagy and Regulation of Lipid Metabolism; 1 An Introduction to Autophagy; 1.1 Types of Autophagy; 1.2 Regulation of Macroautophagy; 2 Autophagy and Lipid Metabolism; 2.1 Autophagy and Regulation of Intracellular Lipid Stores; 2.2 Intracellular Lipids and Regulation of Autophagy; 3 Autophagy and Adipose Tissue; 3.1 Autophagy and White Adipose Tissue; 3.2 Autophagy and Brown Adipose Tissue; 4 Conclusion; References; Gene Co-Expression Modules and Type 2 Diabetes
,
1 Gene Expression Profiling in Diabetes Research2 Coordinated Changes in Gene Expression Provide Physiological Clues; 3 Genetics of Diabetes Susceptibility; 4 Age, Obesity, and Strain Effects on Gene Expression and Diabetes; 5 A Module Enriched in Cell Cycle Transcripts Predicts Diabetes; 6 Cell Cycle Module Shows Heritability; 7 Future Prospects: Heritability Data Can Be Used to Create Network Models; References; Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice; 1 Introduction: Type 2 Diabetes as a Complex Genetic Disease
,
2 Animal Models for the Study of Type 2 Diabetes
,
Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9783642144257
Additional Edition:
Buchausg. u.d.T. Sensory and metabolic control of energy balance Berlin : Springer, 2010 ISBN 9783642144257
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Fettsucht
;
Diabetes mellitus
;
Energiestoffwechsel
;
Lipidstoffwechsel
;
Geschmackssinn
;
Fettsucht
;
Diabetes mellitus
;
Energiestoffwechsel
;
Lipidstoffwechsel
;
Geschmackssinn
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-14426-4
URL:
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