Format:
Online-Ressource (XIV, 392p. 29 illus. in color, digital)
ISBN:
9783642197031
Series Statement:
Current Topics in Behavioral Neurosciences 7
Content:
Common neuropsychiatric diseases are associated with significant human and economic cost. The development of more effective treatments requires scientific progress on a broad front and animal models have a vital role to play in these advances, enabling exploration of the functional consequences of molecular changes at the cellular, systems and behavioural levels. This volume discusses some of the latest and most exciting advances in the field. The first five chapters consider developments in gene modification techniques, their applications in vivo across a variety of species and the latest work related to Schizophrenia, Huntington's Disease and Major Depressive Disorder. Three chapters then focus on recent developments in Autism, Drug Dependence and Attention Deficit Hyperactivity Disorder. In the final four chapters consideration is given to the development of models in larger species and to emergent approaches, such as epigenetic regulation, gene X environment interactions and MRI as a tool for understanding the function of neuronal systems in non- human species, all of which are likely to play an increasingly important role in the scientific discourse related to neuropsychiatric diseases.
Note:
Includes bibliographical references and index
,
Molecular and Functional Models in Neuropsychiatry; Preface; Contents; Contributors; Mouse Mutagenesis and Disease Models for Neuropsychiatric Disorders; 1 Introduction; 2 Forward Genetics with N-Ethyl-N-Nitrosourea; 2.1 Phenotype-Driven Mutagenesis; 2.2 Gene Mapping and Positional Cloning; 2.3 Features of Phenotype-Driven ENU Mouse Mutagenesis; 3 Reverse Genetics with Gene Targeting; 3.1 Gene Targeting; 3.2 Conditional KO Mouse Mutagenesis; 3.3 Features of the International KO Mouse Project; 4 Next-Generation Gene Targeting with ENU
,
4.1 Mutant Mouse Library: G1 Mouse Archives by ENU Mutagenesis4.2 High-Throughput Mutation Discovery Systems; 4.3 Features of ENU-Based Gene-Driven Mutagenesis; 5 Examples of Classic Neurological Mutant Mouse Strains; 5.1 shi, Shiverer; 5.2 pcd, Purkinje Cell Degeneration; 5.3 d, Dilute; 5.4 p, Pink-Eyed Dilution; 6 Mouse Models for Human Neurological Diseases; 6.1 Neurodegenerative Diseases; 6.2 Mental Retardation, Ataxia, and Other Neurological Disorders; 7 Mouse Models for Neurodegenerative Lysosomal Disorders; 7.1 Niemann-Pick C Disease; 7.2 Mucopolysaccharidosis
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7.3 Other Neurodegenerative Lysosomal Storage Disorders8 Mouse Models for Neuropsychiatric Diseases; 8.1 Disrupted in Schizophrenia 1 Gene; 8.2 Serine Racemace Gene; 9 Concluding Remarks; References; Drosophila as a Model Organism for the Study of Neuropsychiatric Disorders; 1 Introduction; 2 The Architecture of the Drosophila Brain and Its Neurotransmitter Systems; 2.1 The Fly Brain; 2.2 Neurotransmitter Systems; 3 Neuropsychiatric Behavioral Disorders in Flies?; 3.1 Fly Behavior; 3.2 Learning and Memory; 3.3 Sleep and Rhythms; 3.4 Addiction; 3.5 Social Behaviors
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4 Human Neuropsychiatric Disorders in Drosophila?4.1 Schizophrenia; 4.2 Other Developmental Disorders: Bipolar Disorder, Autism; 4.3 Mood, Stress, and Attention; 5 Conclusions; References; Transgenic Animal Models of Huntington´s Disease; 1 Introduction to Huntington´s Disease; 2 Cellular and Neuropathology of HD; 3 Aberrant Gene Regulation in HD; 4 Rodent Models of HD and Limitations; 5 Development of HD Nonhuman Primate Models; 6 Germline Nonhuman Primate Model of HD; 7 Limitations of Nonhuman Primate Models and Future Directions; 8 Conclusion; References
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Molecular Genetic Models Related to Schizophrenia and Psychotic Illness: Heuristics and Challenges1 Introduction; 2 Mutant Approaches; 2.1 Constitutive Mutants; 2.2 Conditional Mutants; 2.3 Chemical Mutagenesis; 2.4 RNAi Gene Silencing; 3 Modelling the Psychopathology of Schizophrenia in Mutants; 3.1 Positive Symptoms; 3.2 Negative Symptoms; 3.3 Cognitive Deficits; 3.4 Structural and Pathological Features; 4 Genetic Models Related to Schizophrenia; 4.1 Genetic Models Relating to Putative Dopaminergic Pathophysiology; 4.2 Genetic Models Relating to Putative Glutamatergic Pathophysiology
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4.3 Mutant Models Relating to Candidate Risk Genes
Additional Edition:
ISBN 9783642197024
Additional Edition:
Buchausg. u.d.T. Molecular and functional models in neuropsychiatry Berlin : Springer, 2011 ISBN 9783642197024
Additional Edition:
ISBN 3642197027
Language:
English
Subjects:
Medicine
Keywords:
Neuropsychiatrie
;
Molekulare Medizin
;
Tiermodell
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-19703-1
URL:
Volltext
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