Umfang:
Online-Ressource (IX, 161 p. 29 illus., 10 illus. in color, digital)
ISBN:
9783642305269
Serie:
SpringerBriefs in Microbiology
Inhalt:
This book provides a detailed account of the physico-chemical properties and biological functions of the outer membrane vesicles (OMVs) of different pathogenic and non-pathogenic Gram-negative bacteria. It also includes an authentic record of the first systematic study that discovered the mechanism of OMV formation by a pathogen, Vibrio cholerae, and proposed that the process represented a novel secretory activity of bacteria. Furthermore, the authors present clinical and laboratory data on the use of OMVs as immunogens, as effective and licensed vaccines against Neisseria meningitidis serogroup B infections and on the development of more effective vaccines against other human and animal pathogens including Vibrio cholerae. This volume thus bears witness to the emerging revolution in the field of vaccines against pathogens and closes with a discussion of open questions and future research on OMVs.
Anmerkung:
Description based upon print version of record
,
Outer Membrane Vesicles of Bacteria; Preface; Contents; 1 Discovery of the Outer Membrane Vesicles: Revisiting Contemporary Works; Abstract; 1.1…Introduction; 1.2…Discovery of OMVs; 1.3…Production of OMVs; 1.4…A Novel Secretion Process; 1.5…Bleb Formation Under Abnormal Vis-à-Vis Normal Growth Conditions; 1.6…A Temporary Setback; 1.7…Further Work on Bleb Formation; 1.8…Confirmation of the Discovery by Contemporary Investigators; 1.9…Essential Findings of the Discovery Vis-à-Vis Later Works; References; 2 Gram-Negative Bacteria: The cell Membranes; Abstract; 2.1…Inner and Outer Membranes
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2.2…Structure of OMVs2.3…Chemical Composition of OMVs; 2.4…Proteomic Profile of OMVs; 2.4.1 Isolation and Purification; 2.4.2 Protein Separation; References; 3 Factors Affecting Production of Outer Membrane Vesicles; Abstract; 3.1…Natural and Unnatural OMVs; 3.2…Pathogenic and Nonpathogenic Bacteria; 3.3…Bacterial Growth Conditions; 3.4…Impact of LPS Structure; 3.5…Vesicle Production Within the Infected Host; 3.6…Antibiotic Treatment and Vesicle Formation; 3.7…Stress Response and OMV Production; References; 4 Outer Membrane Vesicles as Carriers of Biomaterials; Abstract
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4.1…Packaging and Predatory Activities4.2…Toxins; 4.3…Non-Toxin Virulence Factors; 4.4…Enrichment of Virulence Factors in OMVs; 4.5…DNA; 4.6…Antibiotics; 4.7…Engineered Recombinant OMVs; References; 5 Outer Membrane Vesicles and the Biofilm Formation; Abstract; References; 6 Outer Membrane Vesicles: Interaction with Prokaryotes and Eukaryotes; Abstract; 6.1…Binding with Target Cells Membrane; 6.2…Fusion with Target Cell Membrane; 6.3…Entry into the Target Cells; References; 7 Biogenesis of Outer Membrane Vesicles; Abstract; 7.1…Model of OMV Biogenesis; References
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8 Release of Outer Membrane Vesicles: Is it a Novel Secretion Mechanism?Abstract; References; 9 Outer Membrane Vesicles: Physiological Medical Applications; Abstract; 9.1…Activation of Innate Immune Response; 9.2…B-Cell Activation by OMVs; 9.3…Interaction of OMVs with Complement System; 9.4…OMV Triggers Cell-Mediated Immunity; 9.5…OMV Stimulates Proinflammatory Response; 9.6…OMVs as Immunogens; 9.6.1 Neisseria meningitidis; 9.6.2 Neisseria lactamica; 9.6.3 Vibrio cholerae; 9.6.4 Acinetobacter baumannii; 9.6.5 Bordetella pertussis; 9.6.6 Burkholderia pseudomallei
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9.6.7 Porphyromonas gingivalis9.6.8 Salmonella typhimurium; 9.6.9 Shigella flexneri; 9.6.10 Treponema pallidum; 9.7…OMVs as Vaccine; 9.7.1 OMVs as Vaccines for Meningococcal Diseases; 9.7.2 Markers of Protection Against Meningococcal Disease; 9.7.3 Challenges for Vaccine Development; 9.7.4 Detergent-Treated OMVs as Vaccine; 9.7.5 Native OMVs as Vaccine; 9.7.6 OMV Vaccines in Combination; 9.7.7 Recombinant OMV Vaccines Using Reverse Vaccinology Approach; 9.7.8 OMVs in Vaccine Delivery; 9.7.9 OMVs as Adjuvant; 9.7.10 OMV as Controlled Release System for Vaccine; References; 10 Concluding Notes
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Abstract
Weitere Ausg.:
ISBN 9783642305252
Weitere Ausg.:
Buchausg. u.d.T. Chatterjee, S. N., 1932 - Outer membrane vesicles of bacteria Heidelberg [u.a.] : Springer, 2012 ISBN 3642305253
Weitere Ausg.:
ISBN 9783642305252
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Gram-negative Bakterien
;
Vesikel
;
Exocytose
DOI:
10.1007/978-3-642-30526-9
URL:
Volltext
(lizenzpflichtig)
Mehr zum Autor:
Chatterjee, S. N. 1932-
Mehr zum Autor:
Chaudhuri, Keya 1952-
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