Format:
Online-Ressource (XIV, 243 p. 154 illus., 73 illus. in color, digital)
ISBN:
9783709110010
Series Statement:
SpringerLink
Content:
Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic
Note:
Description based upon print version of record
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Metal Ions in Neurological Systems; Foreword: Metal Ions in Neurological Systems; References; Preface; Contents; List of contributors; Brain iron metabolism and its perturbation in neurological diseases:; Introduction; A brief overview of iron metabolism and homeostasis; The blood-brain barrier (BBB); Mechanisms for iron transport into and within the brain; Neuronal iron homeostasis; Glial cell iron homeostasis; Astrocytes; Oligodendrocytes; Microglia; Importance of iron in the developing foetus; Ageing and metal-based neurodegeneration
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Oxidaive stress in Alzheimer´s disease and Parkinson´s diseaseIron involvement in Alzheimer´s disease and Parkinson´s disease; Therapeutic considerations; References; Brain changes in iron loading disorders:; Introduction; A few common assumptions about iron and the brain; Past animal studies; Animal studies of how iron supplementation affects brain iron levels; Effects of iron supplementation on brain expression of iron-related genes and proteins; Iron supplementation and the brain microvasculature; Functional changes; Functional effects in haemochromatosis patients and animal models
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Exploratory studies of brain gene expression changes in response to iron statusHigh-throughput advantages and concerns; Explanation of arrays; Normalisation and analysis issues when investigating small magnitude expression changes; Microarray studies of brain gene expression in models of iron disorders; Validation and the limitations of PCR; Other emerging technologies; References; The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson´s disease:; Introduction; Manganese; Copper; Iron; References
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Iron, cysteine and neurodegeneration during Parkinson´s disease:Introduction; Iron in the brain: a short introduction; On Parkinson´s disease, and the involvement of cysteine and iron; Concentrations and location of cysteine and iron; Chemical reactivity of cysteine and iron; Speciation; Cysteine as a nucleophile; Cysteine oxidation; Enzymatic breakdown of cysteine; Acknowledgements; References; Copper uptake and trafficking in the brain:; Introduction; Copper in human physiology; Copper bioavailability; Copper transport across enterocytes; Copper transport in blood
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Copper-dependent enzymes in the central nervous systemCopper uptake and trafficking in brain; Copper chaperones; References; Prion diseases and manganism:; Prion diseases and transition metal ions; Prion diseases and prion protein; Prion protein and transition metal ions; Manganism and labile plasma manganese ions; Manganism; Transport of manganese ion by transferrin to brain; Labile plasma manganese ion; Difference between Fe(II) and Mn(II) ions for oxidation reaction; Labile plasma iron and iron-overload syndrome; Labile plasma iron: formation and toxicity
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Toxicity due to the binuclear iron(III) species: 1
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1. R.R. Crichton, D.T. Dexter, R.J. Ward: Brain iron metabolism and its perturbation in neurological diseases -- 2. E. Milward et al.: Brain changes in iron loading disorders -- 3. I. Paris, J. Segura-Aguilar: The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease -- 4. E. Siakkou, G.N.L. Jameson: Iron, cysteine and neurodegeneration during Parkinson’s disease -- 5. G. Crisponi et al.: Copper uptake and trafficking in the brain -- 6. Y. Nishida: Prion diseases and manganism -- 7. A. Granzotto, P. Zatta: Metal ions and beta-amyloid: conformational modifications and biological aspects -- 8. A. Granzotto et al.: Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions -- 9. Ch. Exley, E.R. House: Aluminium in the human brain -- 10. V.M. Nurchi, G. Crisponi, V. Bertolasi, G. Faa, M. Remelli: Aluminium dependent human diseases and chelating properties of aluminium chelatots for bio-medical applications.-11. M. Suwalsky P.L. Henrnandez, C.P. Sotomayor: Aluminum increases toxic effects of amyloid beta-peptides on human erythrocyte membrane and molecular models -- 12. E. Gaggelli, G. Valensin: Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid -- 13. Y. Nishsida: The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders -- 14. O.G. Tsay, K. Kim, D.G. Churchil: Metal ion role in the CNS under toxic organophosphonate exposure: Traces of understanding and various open questions -- 15. S. Casito, M. Aschner: Heavy metals, behavior and neurodegeneration: Using C elegans to untangle a can of warms -- 16. C. Kallay et al.: The effect of point mutations on copper(II) complexes with peptide fragments encompassin the 106-114 region of human prion protein -- 17. E. Sija et al.: Interactions of pyridinecarboxylix acid chelators with brain metal ions: Cu(II), Zn(II), Al(III) -- 18. S. Bohic et al.: Spatially resolved imaging methods to probe metals in brain -- 19. Y. Ha, O. Tsay, D.G. Churchil: ICP-MS for the neurodegenerative and brain sciences..
Additional Edition:
ISBN 9783709110003
Additional Edition:
Buchausg. u.d.T. Metal ions in neurological systems Wien : Springer, 2012 ISBN 9783709110003
Additional Edition:
ISBN 3709110009
Language:
English
DOI:
10.1007/978-3-7091-1001-0
URL:
Volltext
(lizenzpflichtig)
Author information:
Linert, Wolfgang 1955-
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