Format:
Online-Ressource (LIV, 1108 p. 173 illus., 69 illus. in color, digital)
ISBN:
9783709110652
Series Statement:
SpringerLink
Content:
Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided. The recently discovered C-type lectins as well as further novel super-families of this group of molecules are described in detail. Furthermore, the clinical significance of animal lectins in inflammatory diseases, defects of immune defense and autoimmunity are described and their application as drugs and therapeutic targets is discussed. With the increasing interest in lectins in biomedical research and their therapeutic applications, this book on animal lectins and associated proteins is a must have for researchers in the area
Note:
Description based upon print version of record
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Animal Lectins: Form, Function and Clinical Applications; Foreword I; Foreword II; Preface; Acknowledgments; Contents of Volume 1; Contents of Volume 2; Contributors; Abbreviation; Part I: Introduction; 1 Lectins: An Overview; 1.1 Lectins: Characteristics and Diversity; 1.1.1 Characteristics; 1.1.2 Lectins from Plants; 1.1.3 Lectins in Microorganisms; 1.1.4 Animal Lectins; 1.2 The Animal Lectin Families; 1.2.1 Structural Classification of Lectins; 1.3 C-Type Lectins (CLEC); 1.3.1 Identification of CLEC; 1.3.2 C-Type Lectin Like Domain (CTLD/CLRD)
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1.3.3 Classification of CLRD-Containing Proteins1.3.4 The CLRD Fold; 1.3.4.1 Ca2+-Binding Sites in CLRDs; 1.4 Disulfide Bonds in Lectins and Secondary Structure; 1.4.1 Disulfide Bond; 1.4.2 Pathway for Disulfide Bond Formation in the ER of Eukaryotic Cells; 1.4.3 Arrangement of Disulfide Bonds in CLRDs; 1.4.4 Functional Role of Disulfides in CLRD of Vertebrates; 1.4.5 Disulfide Bonds in Ca2+-Independent Lectins; 1.5 Functions of Lectins; 1.5.1 Lectins in Immune System; 1.5.2 Lectins in Nervous Tissue; 1.6 The Sugar Code and the Lectins as Recepors in System Biology
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1.6.1 Host-Pathogen Interactions1.6.2 Altered Glycosylation in Cancer Cells; 1.6.3 Protein-Carbohydrate Interactions in Immune System; 1.6.4 Glycosylation and the Immune System; 1.6.4.1 Carbohydrate-Mediated Recognition in Immune System; 1.6.4.2 The Impact of Differential Glycosylation on T Cell Responses; 1.6.5 Principles of Protein-Glycan Interactions; 1.7 Applications of Lectin Research and Future Perspectives; 1.7.1 Mannose Receptor-Targeted Vaccines; References; Part II: Intracellular Lectins; 2 Lectins in Quality Control: Calnexin and Calreticulin; 2.1 Chaperons; 2.1.1 Calnexin
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The Calnexin ProteinCalmegin: A Male Germ Cell Specific Homologue of Calnexin; 2.1.2 Calnexin Structure; 2.1.3 Calnexin Binds High-Mannose-Type Oligosaccharides; 2.1.4 Functions of Calnexin; Cnx/Crt as Classical Chaperones of Protein Folding; Cnx/Crt Cycle; Site of Interaction/Substrate Specificity; Cnx as a PACS-2 Cargo Protein; 2.1.5 Patho-Physiology of Calnexin Deficiency; 2.2 Calreticulin; 2.2.1 General Features; 2.2.2 The Protein; Three Structural Domains; i). N-Domain; ii). P-Domain; iii). C-Domain; 2.2.3 Cellular Localization of Calreticulin; 2.2.4 Functions of Calreticulin
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Calreticulin Is a Multi-Process MoleculeCalreticulin as a Chaperone; ER Luminal Ca2+ and Calreticulin Function; Calreticulin Functions Outside ER; Lessons from Calreticulin-Deficient Mice; Calreticulin and Steroid-Sensitive Gene Expression; Destabilization of 3-Untranslated Region of mRNA by Crt; 2.2.5 Structure-Function Relationships in Calnexin and Calreticulin; 2.2.6 Pathophysiological Implications of Calreticulin; Cardiovascular System; Human Pregnancy and Pre-Eclampsia; Crt Interacts with HIV Envelope Protein; Crt Is a Human Rheumatic Disease-Associated Autoantigen
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2.2.7 Similarities and Differences Between Cnx and Crt
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VOLUME 1 -- I. INTRODUCTION -- CHAPTER 1: Lectins: An Overview -- II. INTRACELLULAR LECTINS -- CHAPTER 2: Lectins in Quality Control: Calnexin and Calreticulin -- CHAPTER 3: P-Type Lectins: Cation-dependent Mannose-6-phosphate Receptor -- CHAPTER 4: P-Type Lectins: Cation-independent Mannose-6-phosphate Receptor -- CHAPTER 5: Mannose-6-phosphate Receptor-Homologous Protein Family -- CHAPTER 6: Lectins of ERAD Pathway: F Box Proteins and M-Type Lectins -- III. L-TYPE LECTINS -- CHAPTER 7: L-Type Lectins in ER-Golgi Intermediate Compartment -- CHAPTER 8: Pentraxins: The L-Type Lectins and C-Reactive Protein as a Cardiovascular Risk -- IV. ANIMAL GALECTINS -- CHAPTER 9: Ovrview of Animal Galectin: The Prototype Subfamily -- CHAPTER 10: Galecin-1: Forms and Functions -- CHAPTER 11: Tandem-Repeat Type Galectins -- CHAPTER 12: Galectin-3: Forms, Functions, and Clinical Manifestations -- CHAPTER 13: Galectin-3: A Cancer Marker with Therapeutic Applications -- V. R-TYPE ANIMAL LECTINS -- CHAPTER 14: R-Type Lectin Families -- CHAPTER 15: Mannose Receptor Family: R-Type Lectins -- VI. I-TYPE LECTINS -- CHAPTER 16: I-Type Lectins: Sialoadhesin Family -- CHAPTER 17: CD33 (Siglec 3) and CD33-Related Siglecs.-VII. NOVEL SUPER-FAMILIES OF LECTINS -- CHAPTER 18: Fibrinogen-Type lectins -- CHAPTER 19: Chi-lectins: Forms, Functions and Clinical Applications -- CHAPTER 20: Novel Groups of Fuco-lectins and Intlectins -- CHAPTER 21: Annexins (Lipocortins) -- VOLUME 2 -- VIII. C-TYPE LECTINS -- Collectins -- CHAPTER 22: C-Type Lectins Family -- CHAPTER 23: Collectins: Mannan Binding Protein as a Model Protein -- CHAPTER 24: Pulmonary SP-A: Forms and Functions -- CHAPTER 25: Surfactant Protein-D -- Selectins -- CHAPTER 26: L-selectin (CD62L) and its Ligands -- CHAPTER 27: P-selectin (CD62P) and its Ligands -- CHAPTER 28: E-selectin (CD62E) (Endothelial Leukocyte Adhesion Molecule-1) -- Lectin Receptors on NK Cells -- CHAPTER 29: KLRB Receptor Family and Human Early Activation Antigen (CD69) -- CHAPTER 30: KG2 Subfamily C (KLRC) -- CHAPTER 31: NKG2D Activating Receptor -- CHAPTER 32: KLRC4, KLRG1, and Natural Cytotoxicity Receptors -- Endocytic Receptors -- CHAPTER 33: Asialoglycoprotein Receptor and The Macrophage Galactose- Type Lectin -- CHAPTER 34: Dectin-1 Receptor Family -- CHAPTER 35: Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family) -- CHAPTER 36: DC-SIGN Family of Receptors -- Proteoglycans -- CHAPTER 37: Lectican Protein Family -- CHAPTER 38: Proteoglycans of Central Nervous System -- Emerging Groups of C-Type Lectins -- CHAPTER 39: Regenerating (Reg) Gene Family -- CHAPTER 40: Emerging Groups of C-Type Lectins -- CHAPTER 41: Family of CD93 and Recently Discovered Groups of CTLDs -- IX. CLINICAL SIGNIFICANCE OF ANIMAL LECTINS -- CHAPTER 42: MBL Deficiency as Risk of Infection and Autoimmunity CHAPTER 43: Pulmonary Collectins in Diagnosis and Prevention of Lung Diseases -- CHAPTER 44: Selectins and Associated Adhesion Proteins in Inflammatory Disorders -- CHAPTER 45: Polycystins and Autosomal Polycystic Kidney Disease -- CHAPTER 46: Endogenous Lectins as Drug Targets. .
Additional Edition:
ISBN 9783709110645
Additional Edition:
Buchausg. u.d.T. Gupta, G. S. Animal lectins ; 1 Wien : Springer, 2012 ISBN 9783709110645
Language:
English
Subjects:
Biology
DOI:
10.1007/978-3-7091-1065-2
URL:
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