Umfang:
Online-Ressource (XVII, 238 p. 29 illus., 19 illus. in color, digital)
ISBN:
9783709112069
,
1283935635
,
9781283935630
Serie:
SpringerLink
Inhalt:
Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers
Anmerkung:
Description based upon print version of record
,
Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures; Preface; Acknowledgements; Contents; Acronyms; Chapter 1 Introduction; References; Part I Chemistry and Structure of Dendrimers; Chapter 2 Definition of Terms and Nomenclature; 2.1 Dendriplexes and Dendrisomes; 2.2 Dendrigraft; 2.3 Glycotope; 2.4 Glycocluster; 2.5 Glycocluster-Cluster; 2.6 Cluster Effect and Multivalency; 2.7 Macromolecular Effect; 2.8 Sugar Ball; 2.9 ``Smart'' Glycodendrimers; References; Chapter 3 Sugar Code (Glycocode); References
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Chapter 4 Classes of Peptide-, Glyco-, and Glycopeptide DendrimersReferences; Chapter 5 The Dendritic State and Dendritic Effects; References; Chapter 6 Synthesis of Dendrimers: Convergent and Divergent Approaches; 6.1 Divergent; 6.2 Convergent; 6.3 Lego Chemistry; 6.4 Ligations; 6.5 Click Chemistry; References; Chapter 7 Purification and Characterization of Dendrimers; 7.1 Chromatographic Methods; 7.2 Electromigration Methods; 7.3 Mass Spectrometry; 7.4 Miscellaneous Selected Examples; References; Chapter 8 Dendrimeric Libraries; References; Chapter 9 Dendrimers in Catalysis; References
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Part II Dendrimers and Their Biological and Therapeutic ApplicationsChapter 10 Dendrimers and Solubility; References; Chapter 11 Biocompatibility and Toxicity of Dendrimers; References; Chapter 12 Dendrimers in Nanoscience and Nanotechnology; References; Chapter 13 Dendrimers in Drug Delivery; References; Chapter 14 Dendrimers in Gene Delivery; References; Chapter 15 Dendrimers and Bacteria; 15.1 Escherichia coli; 15.2 Vibrio cholerae; 15.3 Pseudomonas aeruginosa; 15.4 Haemophilus influenzae; 15.5 Mycobacterium tuberculosis; References; Chapter 16 Dendrimers and Viruses; 16.1 Influenza
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16.2 HIV16.3 Other Viruses; References; Chapter 17 Dendrimers and Parasites; References; Chapter 18 Cancer; 18.1 Adjuvant Effects on Dendritic Cells; 18.2 Direct Effects on Tumor Cells; References; Chapter 19 Diagnostics, Lectin Detection and Cell-Cell Interactions; References; Chapter 20 Dendrimers as Biosensors and Imaging Tools; References; Chapter 21 Dendrimers Regulating Intracellular Signaling Pathways; References; Chapter 22 Vaccines and Immunomodulation; 22.1 Antitumor Vaccines; 22.2 Antiviral Vaccines; References; Chapter 23 Dendrimers in Neurodegenerative Diseases
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23.1 Dendrimers as Anti-prion Agents23.2 Dendrimers and Alzheimer's Disease; 23.3 Dendrimers and Parkinson's disease; 23.4 Miscellaneous Applications of Dendrimers in Neurodegenerative Disorders; References; Chapter 24 Conclusions and Perspectives; Index;
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Introduction -- Chemistry and struture to dendrimers: Definition of terms and nomenclature -- Sugar code (glyco code) -- Classes of peptide-, glyco, and glycopeptide dendrimers -- The dendritic state and dendritic effects -- Synthesis of dendrimers: convergent and divergent approaches -- Purification and characterization of dendrimers -- Dendrimeric libraries -- Dendrimers in catalysis.-Dendrimers and their biological and therapeutic applications: Dendrimers and solubility -- Biocompability and toxicity of dendrimers -- Dendrimers in nanoscience and nanotechnology -- Dendrimers in drug delivery -- Dendrimers in gene delivery.-Dendrimers and bacteria -- Dendrimers and viruses -- Dendrimers and parasites -- Cancer -- Diagnostics, lectin detection and cell-cell interactions -- Dendrimers as biosensors and imaging tools -- Dendrimers regulating in intracellular signaling pathways -- Vaccines and immunomodulation -- Dendrimers in neurodegenerative diseases -- Conclusions and persperctives. .
Weitere Ausg.:
ISBN 9783709112052
Weitere Ausg.:
Buchausg. u.d.T. Šebestík, Jaroslav Biomedical applications of peptide-, glyco- and glycopeptide dendrimers, and analogous dendrimeric structures Wien, Heidelberg [u.a.] : Springer, 2012 ISBN 9783709112052
Weitere Ausg.:
ISBN 3709112052
Sprache:
Englisch
DOI:
10.1007/978-3-7091-1206-9
URL:
Volltext
(lizenzpflichtig)
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