UID:
almafu_9958103971202883
Umfang:
1 online resource (X + 204 pages) :
,
33 figures, 10 tables
Ausgabe:
1st ed.
ISBN:
9783318002430
,
3318002437
Serie:
Chemical Immunology and Allergy, Vol.68
Inhalt:
The contributions collected in this volume represent the most recent findings, reviewed by leading scientists in the field, on several different aspects of IL-12 biology. The opening chapter analyzes the molecular regulation of IL-12 production and its immunomodulatory activities. This is followed by three contributions describing the structure of the IL-12 receptor and its role in determining the early events in the differentiation of T cell subsets. The modulation of IL-12 activities by other cytokines such as TGF-Beta, IFN-Gamma and IL-4 is also addressed. IL-12 is a key cytokine that controls infectious diseases and its role in leishmania, candida, and protozoal infections is specifically examined. In addition, IL-12 provides a new tool to explore the regulatory role of the immune system in the control of tumor development and a potential new drug which is already being tested in clinical trials. Finally, the role of IL-12 in Th1-mediated autoimmune diseases and the potential for immunotherapy based on IL-12 targeting is discussed. Collectively, these contributions give a detailed account of the present knowledge on critical aspects of IL-12. The well-edited and stimulating material offered in this volume will be of interest to all immunologists, in particular to those interested in the different facets of the Th1/Th2 dichotomy.
Anmerkung:
Bibliographic Level Mode of Issuance: Monograph
,
CIM1997068000.PDF.pdf -- CIM1997068001 -- CIM1997068023 -- CIM1997068038 -- CIM1997068054 -- CIM1997068070 -- CIM1997068086 -- CIM1997068110 -- CIM1997068136 -- CIM1997068153 -- CIM1997068175 -- CIM1997068198.
,
English
Weitere Ausg.:
ISBN 9783805565264
Weitere Ausg.:
ISBN 3805565267
Sprache:
Englisch
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