UID:
almafu_9958115836802883
Umfang:
1 online resource (300 p.)
ISBN:
9783318009408
,
3318009407
,
9780585471976
,
0585471975
Serie:
Progress in experimental tumor research ; v. 37
Inhalt:
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
Anmerkung:
Description based upon print version of record.
,
""Contents""; ""Preface""; ""Epidemiology of Non-Steroidal Anti- Inflammatory Drugs and Cancer""; ""Pharmacology of COX-2 Inhibitors""; ""Regulation of COX-2 Expression in Human Cancers""; ""Cyclooxygenase-2 and Skin Carcinogenesis""; ""The Role of COX-2 in Breast and Cervical Cancer""; ""Cyclooxygenase-2: A Target for the Prevention and Treatment of Cancers of the Upper Digestive Tract""; ""Cyclooxygenase-2 and Colorectal Cancer""; ""Cyclooxygenase-2 in Lung Cancer""; ""COX-2 Inhibitors and Other NSAIDs in Bladder and Prostate Cancer""
,
""Therapeutic Potential of Selective Cyclooxygenase- 2 Inhibitors in the Management of Tumor Angiogenesis""""Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation""; ""Non-Steroidal Anti-Inflammatory and Cyclooxygenase- 2- Selective Inhibitors in Clinical Cancer Prevention Trials""; ""Chemotherapy with Cyclooxygenase-2 Inhibitors in the Treatment of Malignant Disease: Pre- Clinical Rationale and Preliminary Results of Clinical Trials""; ""Role of COX-Independent Targets of NSAIDs and Related Compounds in Cancer Prevention and Treatment""; ""Author Index""
,
""Subject Index""
,
English
Weitere Ausg.:
ISBN 9783805575362
Weitere Ausg.:
ISBN 380557536X
Sprache:
Englisch
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