UID:
almafu_9958111231102883
Format:
1 online resource (114 p.)
ISBN:
9786613153432
,
9781283153430
,
1283153432
,
9783805590303
,
380559030X
Series Statement:
Developments in ophthalmology, v. 44
Content:
Since the advent of pars plana vitrectomy, immense technical advances in the treatment of retinal diseases have been made. However, some mechanically based limitations of vitreoretinal surgery may result in incomplete removal of the vitreous, especially at the vitreoretinal interface and at the vitreous base. Here, pharmacology can be of assistance. For instance, enzymes that cleave the vitreoretinal junction without damaging the retina or which induce liquefaction may be applied. Neuroprotective and antiproliferative agents may hold the promise of preserving neuronal function when the retina is detached or when proliferative vitreoretinopathy or proliferative diabetic retinopathy has developed. Earlier intervention is possible and can save visual function before the retinal cytoarchitecture is destroyed. Consequently, pharmacologic vitreolysis will change the current concepts of treating retinal and macular diseases. This volume is the first comprehensive up-date on pharmacology-assisted vitreoretinal surgery. Researchers in the fields of medical and surgical retina as well as retinal specialists and vitreoretinal surgeons in clinics will benefit from this topical summary.
Note:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""List of Contributors""; ""Preface""; ""Pharmacologic Vitreolysis""; ""Objective of Pharmacologic Vitreolysis""; ""Abstract""; ""References""; ""Vitreous as a Substrate for Vitreolysis""; ""Abstract""; ""Structural Molecules and Macromolecular Organisation of the Vitreous Humour""; ""Vitreoretinal Adhesion""; ""Vitreous Liquefaction and Posterior Vitreous Detachment""; ""Enzymatic Vitreolysis""; ""References""; ""Hyaluronidase for Pharmacologic Vitreolysis""; ""Abstract""; ""Hyaluronan""; ""Collagen""; ""Supramolecular Organization""; ""Anomalous PVD""
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""Pharmacologic Vitreolysis""""References""; ""Microplasmin-Assisted Vitrectomy""; ""Abstract""; ""Preclinical Evaluation of Plasmin-Assisted Vitrectomy""; ""Preclinical Evaluation of Microplasmin-Assisted Vitrectomy""; ""Clinical Evaluation of Microplasmin-Assisted Vitrectomy""; ""Conclusion""; ""References""; ""Pharmacologic Vitreodynamics and Molecular Flux""; ""Abstract""; ""Molecular Flux""; ""PVD and Vitreous Oxygen Levels""; ""PVD and Other Vitreous Molecules""; ""Conclusion""; ""References""; ""Proliferative Vitreoretinopathy""
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""Cellular Changes in Human PVR""""References""; ""Alkylphosphocholines: A New Approach to Inhibit Cell Proliferation in Proliferative Vitreoretinopathy""; ""Abstract""; ""Cell Biology of Retinal Detachment and Proliferative Vitreoretinopathy""; ""Current Therapeutic Concepts""; ""Alkylphosphocholines""; ""In Vitro Effects""; ""In Vivo Studies""; ""Conclusions/Perspectives""; ""Grant Support""; ""References""; ""Diabetic Retinopathy and Diabetic Macular Edema""; ""Neuroprotection for Diabetic Retinopathy""; ""Abstract""; ""Evidence for Neurodegeneration in Diabetic Retinopathy""
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""Normal Mechanisms for Maintenance of Postmitotic Neurons in the Retina""""Alterations in Normal Cellular Maintenance Pathways in Diabetic Retinopathy""; ""Future Directions""; ""Acknowledgement""; ""References""; ""VEGF Inhibitors and Vitrectomy for Diabetic Vitreoretinopathy""; ""Abstract""; ""Role of the Vitreous and Various Factors Including VEGF in Diabetic Vitreoretinopathy""; ""Anti-VEGF Agents""; ""Corticosteroids and Diabetic Vitreoretinopathy""; ""PPV for DR: Surgical Techniques""; ""Pharmacologicaly-Assisted PPV: Anti-VEGF Agents and Corticosteroids""; ""Conclusions""
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""References""
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English
Additional Edition:
ISBN 9783805590297
Additional Edition:
ISBN 3805590296
Language:
English
Subjects:
Medicine
Keywords:
Aufsatzsammlung
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Aufsatzsammlung
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Aufsatzsammlung
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Aufsatzsammlung
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