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  • 1
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    Berlin : Logos Verlag Berlin
    Details
    UID:
    gbv_1832353575
    Format: 1 Online-Ressource (234 p.)
    ISBN: 9783832554064
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease
    Note: English
    Language: Undetermined
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Stabi Berlin
    UB Potsdam
  • 2
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    [Erscheinungsort nicht ermittelbar]
    Details
    UID:
    gbv_1832378896
    Format: 1 Online-Ressource
    ISBN: 9783832554064
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease
    Note: English
    Language: Undetermined
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Stabi Berlin
    UB Potsdam
  • 3
    Book
    Book
    Searching for order in body clocks : circadian rhythms and redox balance (2021)
    Berlin :Logos Verlag,
    Details
    UID:
    almahu_BV047817209
    Format: xix, 166, XLIV Seiten : , Illustrationen, Diagramme.
    ISBN: 978-3-8325-5406-4
    Note: Dissertation Humboldt-Universität zu Berlin 2021
    Language: English
    Subjects: Biology
    RVK:
    WD 8050
    RVK:
    WD 9200
    Keywords: Tagesrhythmus ; Stoffwechsel ; Mathematisches Modell ; Hochschulschrift
    URL: http://deposit.dnb.de/cgi-bin/dokserv?id=49f89ddcfb644306ae723a5794273893&prov=M&dok_var=1&dok_ext=htm
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    Book
    HU Berlin get availability status
    Berlin VÖBB/ZLB get availability status
  • 4
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    Berlin : Logos Berlin
    Details
    UID:
    gbv_1806733234
    Format: 1 Online-Ressource (234 Seiten)
    Additional Edition: ISBN 9783832554064
    Additional Edition: ISBN 3832554068
    Additional Edition: Erscheint auch als Druck-Ausgabe Olmo, Marta del Searching for Order in Body Clocks Berlin : Logos Berlin, 2021 ISBN 9783832554064
    Additional Edition: ISBN 3832554068
    Language: English
    URL: kostenfrei
    URL: Inhaltstext
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    Online Resource
    Stabi Berlin
  • 5
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    [s.l.] :Logos Verlag Berlin,
    Details
    UID:
    almahu_9949414162102882
    Format: 1 online resource (234 p.)
    ISBN: 9783832554064
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
    Language: English
    Keywords: Electronic books.
    URL: View this content on BiblioBoard.
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    HU Berlin
  • 6
    Online Resource
    Online Resource
    Searching for order in body clocks : circadian rhythms and redox balance (2021)
    Berlin : Logos Verlag
    Details
    UID:
    b3kat_BV047952252
    Format: 1 Online-Ressource
    Note: Dissertation Humboldt-Universität zu Berlin 2021
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8325-5406-4
    Language: English
    Subjects: Biology
    RVK:
    WD 8050
    RVK:
    WD 9200
    Keywords: Tagesrhythmus ; Stoffwechsel ; Mathematisches Modell ; Hochschulschrift
    DOI: 10.30819/5406
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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    Online Resource
    Fulltext
    Fulltext
    Fulltext
    EUV Frankfurt
  • 7
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    Berlin : Logos Verlag Berlin | [s.l.] :Logos Verlag,
    Details
    UID:
    edoccha_9960413075602883
    Format: 1 online resource (234 p.)
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
    Note: English
    Additional Edition: ISBN 3-8325-5406-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Charité
  • 8
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    Berlin : Logos Verlag Berlin | [s.l.] :Logos Verlag,
    Details
    UID:
    almahu_9949282001802882
    Format: 1 online resource (234 p.)
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
    Note: English
    Additional Edition: ISBN 3-8325-5406-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    HU Berlin
  • 9
    Online Resource
    Online Resource
    Searching for Order in Body Clocks : Circadian Rhythms and Redox Balance (2021)
    Berlin : Logos Verlag Berlin | [s.l.] :Logos Verlag,
    Details
    UID:
    edocfu_9960413075602883
    Format: 1 online resource (234 p.)
    Content: Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
    Note: English
    Additional Edition: ISBN 3-8325-5406-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    FU Berlin
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