UID:
almahu_9948025526102882
Format:
1 online resource (555 p.)
ISBN:
1-281-00515-0
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9786611005153
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0-08-049215-0
Content:
Principles of Cloning is the first comprehensive book on animal cloning since the creation of Dolly. The contributing authors are the principal investigators on each of the animal species cloned to date, and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide spotlight late in 2001 when their company, Advanced Cell Technology, announced the successful engineering of the world's first cloned human embryo. The trio was featured in the US News & World Report December 2001 cover story, ""The First H
Note:
Description based upon print version of record.
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Front Cover; Principles of Cloning; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; Introduction; Chapter 1. Historical Perspective; ANCIENT CLONING (ASEXUAL REPRODUCTION)-IN THE BEGINNING; SPONTANEOUS REGENERATION; TYPES OF CLONING; EXAMPLES OF NATURAL CLONING IN HUMANS AND ANIMALS; EXPERIMENTAL CLONING OF NONMAMMALS; CLONING MAMMALS; REFERENCES; Part I: Basic Biological Processes; Chapter 2. Activation of Mammalian Oocytes; INTRODUCTION; REQUIREMENT OF Ca2+ FOR OOCYTE ACTIVATION; HOW DOES THE SPERM TRIGGER Ca2+ RELEASE?; REGULATION OF FERTILIZATION-ASSOCIATED [Ca2+]i OSCILLATIONS
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REQUIREMENTS FOR ASSEMBLY OF COMPETENT PRONUCLEI[Ca2+]i OSCILLATIONS AND APOPTOSIS IN MAMMALIAN OOCYTES; REFERENCES; Chapter 3. The Nucleus; DNA AND GENOME STRUCTURE; DNA-ASSOCIATED PROTEINS IN SOMATIC AND GERM CELLS; THE NUCLEAR ENVELOPE, LAMINA, AND MATRIX: E PLURIBUS UNUM; PERSPECTIVE; UPDATE; REFERENCES; Chapter 4. Nuclear Reprogramming: Biological and Technological Constraints; NUCLEAR TRANSFER TECHNOLOGY AND ITS INFLUENCE ON THE DEVELOPMENT OF CLONED MAMMALS; EPIGENETIC REPROGRAMMING AFTER NUCLEAR TRANSFER; REFERENCES
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Chapter 5. Plasticity of Somatic Nucleus by Epigenetic Reprogramming Via Cell HybridizationINTRODUCTION; NUCLEAR REPROGRAMMING OF SOMATIC CELLS BY HYBRIDIZATION WITH EMBRYONIC STEM CELLS; NUCLEAR REPROGRAMMING OF SOMATIC CELLS BY HYBRIDIZATION WITH EMBRYONIC GERM CELLS; CLONING BY SOMATIC CELL TRANSPLANTATION INTO OOCYTES; CONCLUSION; REFERENCES; Chapter 6. Determinants of Pluripotency in Mammals; INTRODUCTION; DEFINING PLURIPOTENCY BY MEANS OF TOTIPOTENCY; WHY PLURIPOTENCY?; THE FIELDS OF PLURIPOTENCY; LEVELS OF CELL POTENCY; THE CELLULAR BASES OF POTENCY
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PLURIPOTENTIAL STEM CELLS AND CLONINGMETHODS OF ADDRESSING CELL POTENCY; MARKERS OF PLURIPOTENCY; OCT4, A MODERN TOOL FOR ANALYSIS OF PLURIPOTENCY; LESSONS FROM CLONING; REFERENCES; Part II: Methods; Chapter 7. Micromanipulation Techniques for Cloning; INTRODUCTION; MAKING MANIPULATION TOOLS; MICROSCOPY AND EQUIPMENT FOR MICROMANIPULATION; MICROMANIPULATION PROCEDURES; PIEZOELECTRIC ASSISTED NUCLEAR TRANSFER; TECHNICAL IMPROVEMENTS; REFERENCES; Chapter 8. Microinsemination and Nuclear Transfer with Male Germ Cells; INTRODUCTION; MICROINSEMINATION
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NUCLEAR TRANSFER WITH MALE PRIMORDIAL GERM CELLSREFERENCES; Chapter 9. Development of Viable Mammalian Embryos in Vitro: Evolution of Sequential Media; INTRODUCTION; DYNAMICS OF EMBRYO AND MATERNAL PHYSIOLOGY; METABOLISM OF THE EMBRYO; DECREASING INTRACELLULAR STRESS; EVOLUTION OF SEQUENTIAL EMBRYO CULTURE MEDIA; FACTORS OTHER THAN MEDIUM FORMULATION THAT IMPACT EMBRYO DEVELOPMENT AND VIABILITY; INHERENT PROBLEMS OF COCULTURE; CONCLUSIONS; REFERENCES; Chapter 10. Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets; DEFINITION OF CLONING; CYTOPLASMIC GENETICS
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EPIGENETIC EFFECTS
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English
Additional Edition:
ISBN 1-4933-0028-8
Additional Edition:
ISBN 0-12-174597-X
Language:
English
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