UID:
almahu_9948025324702882
Umfang:
1 online resource (365 p.)
ISBN:
1-281-01079-0
,
9786611010799
,
0-08-049816-7
Inhalt:
The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being red
Anmerkung:
Description based upon print version of record.
,
Front Cover; The Somatotrophic Axis in Brain Function; Copyright Page; Contents; Preface; Contributors; Pioneers in the growth hormone field; Introduction; Section I: Biosynthesis of GH and IGF-I and Regulation of Their Secretion; Chapter 1. Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion; Chapter 2. Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor; Section II: GH and IGF-I and their Function at Receptor Level; Chapter 3. Mechanisms of Signal Transduction Utilized by Growth Hormone
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Chapter 4. Insulin-like Growth Factor-I and its Binding Proteins: Regulation of Secretion and Mechanism of Action at Receptor LevelSection III: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System; Chapter 5. Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid; Chapter 6. Growth Hormone, Insulin, and IGF-I: Do They Interact at the Blood-Brain Barrier?; Chapter 7. Growth Hormone and Insulin-like Growth Factors in the CNS: Localisation in Mammalian Species
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Chapter 8. Purification of Growth Hormone Receptors from Human Brain TissuesChapter 9. Growth Hormone Receptor Message in the Rat and Human CNS: Structure and Function; Section IV: CNS Action of Growth Hormone: Basic Studies Using Animal Models; Chapter 10. Interaction of Growth Hormone and Prolactin in Brain Circuits; Chapter 11. Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain; Chapter 12. Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions
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Chapter 13. Rodent Models for the Study of the Role of GH-IGF-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie RestrictionChapter 14. Growth Hormone and Insulin-like Growth Factor-I (IGF-I) and Their Interactions with Brain Circuits Involved in Cognitive Function; Chapter 15. IGF-I and Neuroprotection; Section V: Immediate and Long-Term Benefits on the CNS and GH Replacement Therapy; Chapter 16. Quality of Life in Adult GH Deficiency; Chapter 17. The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology
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Chapter 18. Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life QualityChapter 19. Psychological Importance to the Child of Growth Hormone Replacement; Chapter 20. Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations; Chapter 21. Human Aging and the Growth Hormone/Insulin-like Growth factor-I axis: The Impact of Growth Factors on Dementia; Chapter 22. Cognitive Status of Adult GHD Patients and GH-Induced Neuropsychological Changes
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Chapter 23. Growth Hormone and Insulin-like Growth Factor-I in Alzheimer's Disease
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English
Weitere Ausg.:
ISBN 0-12-088484-4
Sprache:
Englisch
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