UID:
almahu_9948025378402882
Format:
1 online resource (379 p.)
ISBN:
1-281-02405-8
,
9786611024055
,
0-08-051448-0
Content:
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, finechemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring keycompounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates areidentified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, andacademicians (particularly those inv
Note:
Description based upon print version of record.
,
Front Cover; Practical Process Research & Development; Contents; Foreword by K. Barry Sharpless; Foreword by Jerome L. Moniot; Preface; About the Author; Chapter 1. Approaches to Process Development; I. Introduction; II. The Importance of Simple Scale-up Operations; III. The Importance of Teamwork; IV. Determining Operations That Can and Cannot Readily Be Used On Scale; V. Safety Considerations; VI. Taking Advantage of Serendipity and Good Observations; VII. Define the Time Available for Process Optimization; References; Chapter 2. Route Selection; I. Introduction
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II. Characteristics of Expedient RoutesIII. Characteristics of Cost-Effective Routes; IV. Using Cost Estimates to Assess the Ultimate Route; V. Summary; References; Chapter 3. Reagent Selection; I. Introduction; II. The Ideal Reagent for Scale-up; III. Families of Reagents Useful for Scale-up; References; Chapter 4. Solvent Selection; I. Introduction; II. Selecting Solvents Based on Physical Characteristics; III. Selected Solvent Impurities; IV. Applications of Solvents; V. Alternatives to Classical Solvents; References; Chapter 5. Running the Reaction; I. Introduction
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II. Determining Reaction SafetyIII. Assessing Safe Operating Conditions for the Laboratory; IV. Selecting the Reaction Scale; V. Choose Equivalents of Reagents, Starting Materials, and Solvents; VI. Employ Inert Conditions if Needed; VII. Charge Starting Materials and Solvents; VIII. Select Reaction Temperature; IX. Select the Duration and Temperature of an Addition; X. Select the Sequence of Additions; XI. Select Reaction Pressure; XII. Adjust Stirring; XIII. Monitor the Reaction Conditions; References; Chapter 6. Effects of Water; I. Introduction; II. Detecting and Quantitating Water
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III. Removing Water from Routine Organic ProcessingReferences; Chapter 7. In-Process Controls; I. Introduction; II. Choosing the Appropriate IPC; III. Generating Reproducible IPCs; References; Chapter 8. Optimizing the Reaction by Minimizing Impurities; I. Introduction; II. Steps to Optimizing Reactions; III. Minimizing Impurity Formation by Identifying Impurities First; IV. Statistical Design of Experiments; V. Robotics and Automated Process Optimization; References; Chapter 9. Optimizing Catalytic Reactions; I. Introduction; II. Catalyst Selection/Ligand Selection
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III. Optimizing Catalyst ConcentrationIV. Generating Active Catalysts; V. Importance of Extended Additions; VI. Influence of Co-catalysts and Impurities; VII. Catalyst Decomposition; VIII. Nonlinear Catalyst Effects; IX. The Difficulty of Optimizing a Catalytic Reaction; References; Chapter 10. Work-up; I. Introduction; II. Aspects of Work-up; References; Chapter 11. Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying; I. Introduction; II. Purification by Column Chromatography; III. Crystallization; IV. Purification by Reslurrying; References
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Chapter 12. Final Product Form and Impurity Considerations
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English
Additional Edition:
ISBN 1-4832-9977-5
Additional Edition:
ISBN 0-12-059475-7
Language:
English
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